ID   ANP3_MYOSC              Reviewed;          33 AA.
AC   P04367;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Ice-structuring protein SS-3;
DE            Short=ISP SS-3;
DE   AltName: Full=Antifreeze peptide SS-3;
OS   Myoxocephalus scorpius (Shorthorn sculpin) (Cottus scorpius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Cottales; Cottidae; Myoxocephalus.
OX   NCBI_TaxID=8097;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=4029130; DOI=10.1111/j.1432-1033.1985.tb09081.x;
RA   Hew C.-L., Joshi S., Wang N.-C., Kao M.H., Ananthanarayanan V.S.;
RT   "Structures of shorthorn sculpin antifreeze polypeptides.";
RL   Eur. J. Biochem. 151:167-172(1985).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=8626748; DOI=10.1074/jbc.271.8.4106;
RA   Gong Z., Ewart K.V., Hu Z., Fletcher G.L., Hew C.-L.;
RT   "Skin antifreeze protein genes of the winter flounder, Pleuronectes
RT   americanus, encode distinct and active polypeptides without the secretory
RT   signal and prosequences.";
RL   J. Biol. Chem. 271:4106-4112(1996).
RN   [3]
RP   STRUCTURE BY NMR.
RX   PubMed=15697223; DOI=10.1021/bi047782j;
RA   Kwan A.H., Fairley K., Anderberg P.I., Liew C.W., Harding M.M.,
RA   Mackay J.P.;
RT   "Solution structure of a recombinant type I sculpin antifreeze protein.";
RL   Biochemistry 44:1980-1988(2005).
CC   -!- FUNCTION: Antifreeze proteins lower the blood freezing point.
CC   -!- SIMILARITY: Belongs to the type-I AFP family. {ECO:0000305}.
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DR   PIR; A05162; A05162.
DR   PDB; 1Y03; NMR; -; A=1-33.
DR   PDB; 1Y04; NMR; -; A=1-33.
DR   PDBsum; 1Y03; -.
DR   PDBsum; 1Y04; -.
DR   AlphaFoldDB; P04367; -.
DR   SMR; P04367; -.
DR   EvolutionaryTrace; P04367; -.
PE   1: Evidence at protein level;
KW   3D-structure; Antifreeze protein; Direct protein sequencing; Repeat.
FT   CHAIN           1..33
FT                   /note="Ice-structuring protein SS-3"
FT                   /id="PRO_0000155144"
FT   HELIX           3..6
FT                   /evidence="ECO:0007829|PDB:1Y03"
FT   HELIX           7..9
FT                   /evidence="ECO:0007829|PDB:1Y03"
FT   HELIX           10..28
FT                   /evidence="ECO:0007829|PDB:1Y03"
SQ   SEQUENCE   33 AA;  2939 MW;  8B74CC4C06A1208A CRC64;
     MNAPARAAAK TAADALAAAK KTAADAAAAA AAA