ANPE_ZOAAM
ID ANPE_ZOAAM Reviewed; 87 AA.
AC P19605;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Ice-structuring protein C10;
DE Short=ISP C10;
DE AltName: Full=Antifreeze protein C10;
DE Flags: Precursor;
OS Zoarces americanus (Ocean pout) (Macrozoarces americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Zoarcales; Zoarcidae; Zoarcinae;
OC Zoarces.
OX NCBI_TaxID=8199;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3403560; DOI=10.1016/s0021-9258(18)37891-8;
RA Hew C.-L., Wang N.-C., Joshi S., Fletcher G.L., Scott G.K., Hayes P.H.,
RA Buettner B., Davies P.L.;
RT "Multiple genes provide the basis for antifreeze protein diversity and
RT dosage in the ocean pout, Macrozoarces americanus.";
RL J. Biol. Chem. 263:12049-12055(1988).
CC -!- FUNCTION: Contributes to protect fish blood from freezing at subzero
CC sea water temperatures. Lowers the blood freezing point. Binds to
CC nascent ice crystals and prevents further growth (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the type-III AFP family. {ECO:0000305}.
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DR PIR; A31075; A31075.
DR AlphaFoldDB; P19605; -.
DR SMR; P19605; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR006190; AFP_Neu5c_C.
DR InterPro; IPR036732; AFP_Neu5c_C_sf.
DR InterPro; IPR006013; Antifreeze_III.
DR InterPro; IPR013974; SAF.
DR PRINTS; PR00357; ANTIFREEZIII.
DR SMART; SM00858; SAF; 1.
DR SUPFAM; SSF51269; SSF51269; 1.
DR PROSITE; PS50844; AFP_LIKE; 1.
PE 3: Inferred from homology;
KW Antifreeze protein; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..87
FT /note="Ice-structuring protein C10"
FT /id="PRO_0000001693"
FT DOMAIN 24..83
FT /note="AFP-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00021"
FT SITE 29
FT /note="Important for ice-binding"
FT /evidence="ECO:0000250"
FT SITE 34
FT /note="Important for ice-binding"
FT /evidence="ECO:0000250"
FT SITE 38
FT /note="Important for ice-binding"
FT /evidence="ECO:0000250"
FT SITE 64
FT /note="Important for ice-binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 87 AA; 9306 MW; 92655F2AC313A0B5 CRC64;
MKSVILTGLL FVLLCVDHMT ASQSVVATQL IPMNSALTPV MMEGKVTNPI GIPFAEMSQM
VGKQVNRPVA KGQTIMPNMV KTYAAGK