ANPRC_BOVIN
ID ANPRC_BOVIN Reviewed; 537 AA.
AC P10730; P20644;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Atrial natriuretic peptide receptor 3;
DE AltName: Full=Atrial natriuretic peptide clearance receptor;
DE AltName: Full=Atrial natriuretic peptide receptor type C;
DE Short=ANP-C;
DE Short=ANPR-C;
DE Short=NPR-C;
DE Flags: Precursor;
GN Name=NPR3; Synonyms=ANPRC;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2837487; DOI=10.1016/s0021-9258(19)76554-5;
RA Fuller F., Porter J.G., Arfsten A.E., James J.M., Schilling J.W.,
RA Scarborough R.M., Lewicki J.A., Schenk D.B.;
RT "Atrial natriuretic peptide clearance receptor. Complete sequence and
RT functional expression of cDNA clones.";
RL J. Biol. Chem. 263:9395-9401(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX PubMed=1645726; DOI=10.1016/s0021-9258(18)99136-2;
RA Saheki T., Mizuno T., Iwata T., Saito Y., Nagasawa T., Mizuno K.U., Ito F.,
RA Ito T., Hagiwara H., Hirose S.;
RT "Structure of the bovine atrial natriuretic peptide receptor (type C)
RT gene.";
RL J. Biol. Chem. 266:11122-11125(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=8444892; DOI=10.1016/s0021-9258(18)53515-8;
RA Mizuno T., Iwashina M., Itakura M., Hagiwara H., Hirose S.;
RT "A variant form of the type C atrial natriuretic peptide receptor generated
RT by alternative RNA splicing.";
RL J. Biol. Chem. 268:5162-5167(1993).
RN [4]
RP PROTEIN SEQUENCE OF 151-179; 310-325 AND 446-452.
RC TISSUE=Lung;
RX PubMed=2557006; DOI=10.1042/bj2630671;
RA Uchida K., Mizuno T., Shimonaka M., Sugiura N., Nara K., Ling N.,
RA Hagiwara H., Hirose S.;
RT "Purification and properties of active atrial-natriuretic-peptide receptor
RT (type C) from bovine lung.";
RL Biochem. J. 263:671-678(1989).
RN [5]
RP DISULFIDE BONDS.
RX PubMed=8132555; DOI=10.1016/s0021-9258(17)37195-8;
RA Itakura M., Iwashina M., Mizuno T., Ito T., Hagiwara H., Hirose S.;
RT "Mutational analysis of disulfide bridges in the type C atrial natriuretic
RT peptide receptor.";
RL J. Biol. Chem. 269:8314-8318(1994).
CC -!- FUNCTION: Receptor for the natriuretic peptide hormones, binding with
CC similar affinities atrial natriuretic peptide NPPA/ANP, brain
CC natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP.
CC May function as a clearance receptor for NPPA, NPPB and NPPC,
CC regulating their local concentrations and effects. May regulate
CC diuresis, blood pressure and skeletal development. Does not have
CC guanylate cyclase activity. {ECO:0000250|UniProtKB:P70180}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with OSTN.
CC {ECO:0000250|UniProtKB:P17342, ECO:0000250|UniProtKB:P70180}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P17342};
CC Single-pass type I membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P10730-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P10730-2; Sequence=VSP_001811;
CC -!- MISCELLANEOUS: Has low affinity for peptide hormones in the absence of
CC bound chloride. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ANF receptor family. {ECO:0000305}.
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DR EMBL; J03876; AAA30376.1; -; mRNA.
DR EMBL; D90372; BAA14380.1; -; Genomic_DNA.
DR EMBL; D13508; BAA02726.1; -; mRNA.
DR PIR; A28111; A28111.
DR PIR; A45409; A45409.
DR RefSeq; NP_776552.1; NM_174127.2.
DR AlphaFoldDB; P10730; -.
DR SMR; P10730; -.
DR STRING; 9913.ENSBTAP00000036561; -.
DR PaxDb; P10730; -.
DR GeneID; 281358; -.
DR KEGG; bta:281358; -.
DR CTD; 4883; -.
DR eggNOG; KOG1023; Eukaryota.
DR InParanoid; P10730; -.
DR OrthoDB; 1423201at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016941; F:natriuretic peptide receptor activity; ISS:UniProtKB.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0002158; P:osteoclast proliferation; ISS:UniProtKB.
DR GO; GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.
DR GO; GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
DR GO; GO:0033688; P:regulation of osteoblast proliferation; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; ISS:UniProtKB.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00458; ANF_RECEPTORS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..41
FT /evidence="ECO:0000255"
FT /id="PRO_0000012368"
FT CHAIN 42..537
FT /note="Atrial natriuretic peptide receptor 3"
FT /id="PRO_0000012369"
FT TOPO_DOM 42..477
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 501..537
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 390
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..132
FT /evidence="ECO:0000269|PubMed:8132555"
FT DISULFID 209..257
FT /evidence="ECO:0000269|PubMed:8132555"
FT DISULFID 469
FT /note="Interchain"
FT /evidence="ECO:0000269|PubMed:8132555"
FT VAR_SEQ 472..473
FT /note="SG -> C (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8444892"
FT /id="VSP_001811"
FT CONFLICT 324
FT /note="V -> A (in Ref. 1; AAA30376)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 537 AA; 59766 MW; B6AC89950FE6E996 CRC64;
MPSLLVLTFS ACVLLGWALL ADCTGGGGSG GAGPGRGRRE REALPPQKIE VLVLLPQDDS
YLFSLARVRP AIEYALRTVE GNATGRRLLP AGTRFQVAYE DSDCGNRALF SLVDRVAAAR
GAKPDLILGP VCEYAAAPVA RLASHWDLPM LSAGALAAGF QHKDTEYSHL TRVAPSYAKM
GEMMLALFRH HQWSRAVLVY SDDKLERNCF FTLEGVHEVF QEEGLHTSAY NFDETKDLDL
EDIVRHIQAS ERVVIMCASS DTIRGIMLAA HRHGMTSGDY AFFNIELFNS SFYGDGSWKR
GDKHDFEAKQ AYSSLQTITL LRTVKPEFEK FSMEVKSSVE KQGLSEEDYV NMFVEGFHDA
ILLYVLALRE VLRAGYSKKD GGKIIQQTWN RTFEGIAGQV SIDANGDRYG DFSVIAMTDT
EAGTQEVIGD YFGKEGRFEM RPNVKYPWGP LKLRIDETRM VEHTNSSPCK ASGGLEESAV
TGIVVGALLG AGLLMAFYFF RKKYRITIER RNQQEESNVG KHRELREDSI RSHFSVA
