ANR10_HUMAN
ID ANR10_HUMAN Reviewed; 420 AA.
AC Q9NXR5; Q5VW12; Q9BV12;
DT 22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Ankyrin repeat domain-containing protein 10;
GN Name=ANKRD10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NXR5; Q92624: APPBP2; NbExp=3; IntAct=EBI-10316475, EBI-743771;
CC Q9NXR5-2; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-12102070, EBI-12006308;
CC Q9NXR5-2; P33240: CSTF2; NbExp=3; IntAct=EBI-12102070, EBI-711360;
CC Q9NXR5-2; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-12102070, EBI-2807642;
CC Q9NXR5-2; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-12102070, EBI-12018822;
CC Q9NXR5-2; O75420: GIGYF1; NbExp=3; IntAct=EBI-12102070, EBI-947774;
CC Q9NXR5-2; P32242: OTX1; NbExp=3; IntAct=EBI-12102070, EBI-740446;
CC Q9NXR5-2; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-12102070, EBI-11022007;
CC Q9NXR5-2; Q9UBV8: PEF1; NbExp=3; IntAct=EBI-12102070, EBI-724639;
CC Q9NXR5-2; P78337: PITX1; NbExp=3; IntAct=EBI-12102070, EBI-748265;
CC Q9NXR5-2; Q99697-2: PITX2; NbExp=3; IntAct=EBI-12102070, EBI-12138495;
CC Q9NXR5-2; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-12102070, EBI-1389308;
CC Q9NXR5-2; P78424: POU6F2; NbExp=3; IntAct=EBI-12102070, EBI-12029004;
CC Q9NXR5-2; Q92529: SHC3; NbExp=3; IntAct=EBI-12102070, EBI-79084;
CC Q9NXR5-2; P09234: SNRPC; NbExp=3; IntAct=EBI-12102070, EBI-766589;
CC Q9NXR5-2; O43711: TLX3; NbExp=5; IntAct=EBI-12102070, EBI-3939165;
CC Q9NXR5-2; Q15645: TRIP13; NbExp=3; IntAct=EBI-12102070, EBI-358993;
CC Q9NXR5-2; Q15915: ZIC1; NbExp=3; IntAct=EBI-12102070, EBI-11963196;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NXR5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NXR5-2; Sequence=VSP_034637, VSP_034638;
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DR EMBL; AK000100; BAA90945.1; -; mRNA.
DR EMBL; AL157875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL442128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471085; EAX09134.1; -; Genomic_DNA.
DR EMBL; CH471085; EAX09135.1; -; Genomic_DNA.
DR EMBL; BC001727; AAH01727.1; -; mRNA.
DR CCDS; CCDS66580.1; -. [Q9NXR5-2]
DR CCDS; CCDS9520.1; -. [Q9NXR5-1]
DR RefSeq; NP_001273650.1; NM_001286721.1. [Q9NXR5-2]
DR RefSeq; NP_060134.2; NM_017664.3. [Q9NXR5-1]
DR AlphaFoldDB; Q9NXR5; -.
DR SMR; Q9NXR5; -.
DR BioGRID; 120748; 21.
DR IntAct; Q9NXR5; 20.
DR STRING; 9606.ENSP00000267339; -.
DR iPTMnet; Q9NXR5; -.
DR PhosphoSitePlus; Q9NXR5; -.
DR BioMuta; ANKRD10; -.
DR DMDM; 212287924; -.
DR EPD; Q9NXR5; -.
DR jPOST; Q9NXR5; -.
DR MassIVE; Q9NXR5; -.
DR MaxQB; Q9NXR5; -.
DR PaxDb; Q9NXR5; -.
DR PeptideAtlas; Q9NXR5; -.
DR PRIDE; Q9NXR5; -.
DR ProteomicsDB; 83122; -. [Q9NXR5-1]
DR ProteomicsDB; 83123; -. [Q9NXR5-2]
DR Antibodypedia; 67648; 56 antibodies from 15 providers.
DR DNASU; 55608; -.
DR Ensembl; ENST00000267339.6; ENSP00000267339.2; ENSG00000088448.14. [Q9NXR5-1]
DR Ensembl; ENST00000310847.8; ENSP00000312534.4; ENSG00000088448.14. [Q9NXR5-2]
DR GeneID; 55608; -.
DR KEGG; hsa:55608; -.
DR MANE-Select; ENST00000267339.6; ENSP00000267339.2; NM_017664.4; NP_060134.2.
DR UCSC; uc001vrn.5; human. [Q9NXR5-1]
DR CTD; 55608; -.
DR DisGeNET; 55608; -.
DR GeneCards; ANKRD10; -.
DR HGNC; HGNC:20265; ANKRD10.
DR HPA; ENSG00000088448; Low tissue specificity.
DR neXtProt; NX_Q9NXR5; -.
DR OpenTargets; ENSG00000088448; -.
DR PharmGKB; PA134911073; -.
DR VEuPathDB; HostDB:ENSG00000088448; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000156564; -.
DR HOGENOM; CLU_052448_0_0_1; -.
DR InParanoid; Q9NXR5; -.
DR OMA; EQRYDNT; -.
DR PhylomeDB; Q9NXR5; -.
DR TreeFam; TF330752; -.
DR PathwayCommons; Q9NXR5; -.
DR SignaLink; Q9NXR5; -.
DR BioGRID-ORCS; 55608; 15 hits in 1079 CRISPR screens.
DR ChiTaRS; ANKRD10; human.
DR GenomeRNAi; 55608; -.
DR Pharos; Q9NXR5; Tdark.
DR PRO; PR:Q9NXR5; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q9NXR5; protein.
DR Bgee; ENSG00000088448; Expressed in calcaneal tendon and 204 other tissues.
DR ExpressionAtlas; Q9NXR5; baseline and differential.
DR Genevisible; Q9NXR5; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..420
FT /note="Ankyrin repeat domain-containing protein 10"
FT /id="PRO_0000066905"
FT REPEAT 21..50
FT /note="ANK 1"
FT REPEAT 57..86
FT /note="ANK 2"
FT REPEAT 91..120
FT /note="ANK 3"
FT REPEAT 124..153
FT /note="ANK 4"
FT VAR_SEQ 152..220
FT /note="DLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFP
FT NHISVGTNRKRCLEDSE -> EFISQSSVHSCLPGELQHGVTFDPSVLIQCLKPEKCQW
FT PDSSRHCTNPGFPRVCPVSLEPPELSSEPFL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034637"
FT VAR_SEQ 221..420
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034638"
FT VARIANT 320
FT /note="P -> L (in dbSNP:rs3742185)"
FT /id="VAR_020095"
FT CONFLICT 176
FT /note="F -> S (in Ref. 1; BAA90945)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 420 AA; 44768 MW; 3656BE31D8B9CB23 CRC64;
MSAAGAGAGV EAGFSSEELL SLRFPLHRAC RDGDLATLCS LLQQTPHAHL ASEDSFYGWT
PVHWAAHFGK LECLVQLVRA GATLNVSTTR YAQTPAHIAA FGGHPQCLVW LIQAGANINK
PDCEGETPIH KAARSGSLEC ISALVANGAH VDLRNASGLT AADIAQTQGF QECAQFLLNL
QNCHLNHFYN NGILNGGHQN VFPNHISVGT NRKRCLEDSE DFGVKKARTE AQSLDSAVPL
TNGDTEDDAD KMHVDREFAV VTDMKNSSSV SNTLTNGCVI NGHLDFPSTT PLSGMESRNG
QCLTGTNGIS SGLAPGQPFP SSQGSLCISG TEEPEKTLRA NPELCGSLHL NGSPSSCIAS
RPSWVEDIGD NLYYGHYHGF GDTAESIPEL NSVVEHSKSV KVQERYDSAV LGTMHLHHGS
