ID   ANR10_MOUSE             Reviewed;         415 AA.
AC   Q99LW0; Q8BGB6;
DT   22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Ankyrin repeat domain-containing protein 10;
GN   Name=Ankrd10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AK082875; BAC38664.1; -; mRNA.
DR   EMBL; AK088371; BAC40310.1; -; mRNA.
DR   EMBL; CH466566; EDL22072.1; -; Genomic_DNA.
DR   EMBL; BC002198; AAH02198.1; -; mRNA.
DR   CCDS; CCDS22098.1; -.
DR   RefSeq; NP_001268903.1; NM_001281974.1.
DR   RefSeq; NP_598732.2; NM_133971.3.
DR   AlphaFoldDB; Q99LW0; -.
DR   SMR; Q99LW0; -.
DR   STRING; 10090.ENSMUSP00000033905; -.
DR   iPTMnet; Q99LW0; -.
DR   PhosphoSitePlus; Q99LW0; -.
DR   EPD; Q99LW0; -.
DR   MaxQB; Q99LW0; -.
DR   PaxDb; Q99LW0; -.
DR   PRIDE; Q99LW0; -.
DR   ProteomicsDB; 296253; -.
DR   Antibodypedia; 67648; 56 antibodies from 15 providers.
DR   DNASU; 102334; -.
DR   Ensembl; ENSMUST00000033905; ENSMUSP00000033905; ENSMUSG00000031508.
DR   GeneID; 102334; -.
DR   KEGG; mmu:102334; -.
DR   UCSC; uc009kvo.3; mouse.
DR   CTD; 55608; -.
DR   MGI; MGI:1921840; Ankrd10.
DR   VEuPathDB; HostDB:ENSMUSG00000031508; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000156564; -.
DR   HOGENOM; CLU_052448_0_0_1; -.
DR   InParanoid; Q99LW0; -.
DR   OMA; EQRYDNT; -.
DR   OrthoDB; 920538at2759; -.
DR   PhylomeDB; Q99LW0; -.
DR   TreeFam; TF330752; -.
DR   BioGRID-ORCS; 102334; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Ankrd10; mouse.
DR   PRO; PR:Q99LW0; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q99LW0; protein.
DR   Bgee; ENSMUSG00000031508; Expressed in optic fissure and 262 other tissues.
DR   ExpressionAtlas; Q99LW0; baseline and differential.
DR   Genevisible; Q99LW0; MM.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..415
FT                   /note="Ankyrin repeat domain-containing protein 10"
FT                   /id="PRO_0000066906"
FT   REPEAT          20..49
FT                   /note="ANK 1"
FT   REPEAT          56..85
FT                   /note="ANK 2"
FT   REPEAT          90..119
FT                   /note="ANK 3"
FT   REPEAT          123..152
FT                   /note="ANK 4"
FT   REGION          303..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        7
FT                   /note="A -> V (in Ref. 2; AAH02198)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   415 AA;  43975 MW;  AD90434935B28509 CRC64;
     MSAGAGAAVE AGFSSEELLS LRFPLHRACR DGDLVALCSL LPHTPRAHLA AEDSFYGWTP
     VHWAAHFGKL ECLMQLVRAG ASLNVSTTRY AQTPAHIAAF GGHPQCLVWL IQAGANINKP
     DCEGETPIHK AARSGSLECI TALVGSGAHT DLRNASGLTA ADIAQTQGFQ ECTQFLLSLQ
     NHQMSRFCHN GTLSGGHESI LPTHVSLGTN RKRCLEDSES LGVKKARTRV PSLDHAMPLA
     NGEAEDDADR MHVDRECAAV SDMKNSSSVL NTLTNGSVVN GHLDFPCANQ LNGMESRSHP
     CLTGSNGVSN GQPLSSGQAS VSANGTEEPE KTMGINPEMC GSLHLNGSPS SCVASRPSWV
     GDIGESLHYG HYHGFGDTAE SIPELSSVLE HTSCVRVEQR YDSAVLGAMQ LHHGS