ANR12_HUMAN
ID ANR12_HUMAN Reviewed; 2062 AA.
AC Q6UB98; O94951; Q658K1; Q6QMF7; Q9H231; Q9H784;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Ankyrin repeat domain-containing protein 12;
DE AltName: Full=Ankyrin repeat-containing cofactor 2;
DE AltName: Full=GAC-1 protein;
GN Name=ANKRD12; Synonyms=ANCO2, KIAA0874;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Ilyin G.P.;
RT "GAC-1 protein containing ankyrin repeats.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-171, AND SUBCELLULAR
RP LOCATION.
RA Powell J.A., Settasatian C., Lower K., Callen D.F.;
RT "ANKRD11 and ANKRD12 are novel 9kb genes encoding nuclear-located proteins
RT with ankyrin domains.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND
RP INTERACTION WITH P160.
RX PubMed=15184363; DOI=10.1074/jbc.m403997200;
RA Zhang A., Yeung P.L., Li C.-W., Tsai S.-C., Dinh G.K., Wu X., Li H.,
RA Chen J.D.;
RT "Identification of a novel family of ankyrin repeats-containing cofactors
RT for p160 nuclear receptor coactivators.";
RL J. Biol. Chem. 279:33799-33805(2004).
RN [4]
RP SEQUENCE REVISION.
RA Chen J.D.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ARG-906.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-484, AND VARIANT THR-171.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1462-2062.
RC TISSUE=Brain;
RX PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:355-364(1998).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-861, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Platelet;
RX PubMed=18088087; DOI=10.1021/pr0704130;
RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT "Phosphoproteome of resting human platelets.";
RL J. Proteome Res. 7:526-534(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-543; SER-630 AND
RP SER-1401, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP VARIANT CYS-307.
RX PubMed=29463886; DOI=10.1038/s41380-018-0020-x;
RA Eising E., Carrion-Castillo A., Vino A., Strand E.A., Jakielski K.J.,
RA Scerri T.S., Hildebrand M.S., Webster R., Ma A., Mazoyer B., Francks C.,
RA Bahlo M., Scheffer I.E., Morgan A.T., Shriberg L.D., Fisher S.E.;
RT "A set of regulatory genes co-expressed in embryonic human brain is
RT implicated in disrupted speech development.";
RL Mol. Psychiatry 24:1065-1078(2019).
CC -!- FUNCTION: May recruit HDACs to the p160 coactivators/nuclear receptor
CC complex to inhibit ligand-dependent transactivation.
CC -!- SUBUNIT: Interacts with the PAS region of the p160 coactivators.
CC {ECO:0000269|PubMed:15184363}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15184363,
CC ECO:0000269|Ref.2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UB98-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UB98-2; Sequence=VSP_010901;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15014.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AF317425; AAG38609.1; -; mRNA.
DR EMBL; AY373757; AAR25662.1; -; mRNA.
DR EMBL; AY533564; AAS45545.2; -; mRNA.
DR EMBL; AL834204; CAH56382.1; -; mRNA.
DR EMBL; AK024808; BAB15014.1; ALT_SEQ; mRNA.
DR EMBL; AB020681; BAA74897.1; -; mRNA.
DR CCDS; CCDS11843.1; -. [Q6UB98-1]
DR CCDS; CCDS42411.1; -. [Q6UB98-2]
DR RefSeq; NP_001077094.1; NM_001083625.2. [Q6UB98-2]
DR RefSeq; NP_001190985.1; NM_001204056.1. [Q6UB98-2]
DR RefSeq; NP_056023.3; NM_015208.4. [Q6UB98-1]
DR RefSeq; XP_005258149.1; XM_005258092.3. [Q6UB98-1]
DR RefSeq; XP_005258150.1; XM_005258093.3. [Q6UB98-1]
DR RefSeq; XP_016881152.1; XM_017025663.1. [Q6UB98-2]
DR AlphaFoldDB; Q6UB98; -.
DR SMR; Q6UB98; -.
DR BioGRID; 116857; 25.
DR IntAct; Q6UB98; 17.
DR STRING; 9606.ENSP00000262126; -.
DR CarbonylDB; Q6UB98; -.
DR iPTMnet; Q6UB98; -.
DR PhosphoSitePlus; Q6UB98; -.
DR BioMuta; ANKRD12; -.
DR DMDM; 160358772; -.
DR EPD; Q6UB98; -.
DR jPOST; Q6UB98; -.
DR MassIVE; Q6UB98; -.
DR MaxQB; Q6UB98; -.
DR PaxDb; Q6UB98; -.
DR PeptideAtlas; Q6UB98; -.
DR PRIDE; Q6UB98; -.
DR ProteomicsDB; 67404; -. [Q6UB98-1]
DR ProteomicsDB; 67405; -. [Q6UB98-2]
DR Antibodypedia; 6510; 60 antibodies from 12 providers.
DR DNASU; 23253; -.
DR Ensembl; ENST00000262126.9; ENSP00000262126.3; ENSG00000101745.17. [Q6UB98-1]
DR Ensembl; ENST00000400020.7; ENSP00000382897.3; ENSG00000101745.17. [Q6UB98-2]
DR GeneID; 23253; -.
DR KEGG; hsa:23253; -.
DR MANE-Select; ENST00000262126.9; ENSP00000262126.3; NM_015208.5; NP_056023.3.
DR UCSC; uc002knv.4; human. [Q6UB98-1]
DR CTD; 23253; -.
DR DisGeNET; 23253; -.
DR GeneCards; ANKRD12; -.
DR HGNC; HGNC:29135; ANKRD12.
DR HPA; ENSG00000101745; Tissue enhanced (brain).
DR MIM; 610616; gene.
DR neXtProt; NX_Q6UB98; -.
DR OpenTargets; ENSG00000101745; -.
DR PharmGKB; PA134899860; -.
DR VEuPathDB; HostDB:ENSG00000101745; -.
DR eggNOG; ENOG502QQG5; Eukaryota.
DR GeneTree; ENSGT00940000154742; -.
DR HOGENOM; CLU_001632_0_0_1; -.
DR InParanoid; Q6UB98; -.
DR OMA; QTKPWDV; -.
DR OrthoDB; 854133at2759; -.
DR PhylomeDB; Q6UB98; -.
DR TreeFam; TF326440; -.
DR PathwayCommons; Q6UB98; -.
DR SignaLink; Q6UB98; -.
DR BioGRID-ORCS; 23253; 16 hits in 1084 CRISPR screens.
DR ChiTaRS; ANKRD12; human.
DR GenomeRNAi; 23253; -.
DR Pharos; Q6UB98; Tbio.
DR PRO; PR:Q6UB98; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q6UB98; protein.
DR Bgee; ENSG00000101745; Expressed in calcaneal tendon and 198 other tissues.
DR ExpressionAtlas; Q6UB98; baseline and differential.
DR Genevisible; Q6UB98; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Disease variant; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..2062
FT /note="Ankyrin repeat domain-containing protein 12"
FT /id="PRO_0000066908"
FT REPEAT 184..213
FT /note="ANK 1"
FT REPEAT 217..246
FT /note="ANK 2"
FT REPEAT 250..280
FT /note="ANK 3"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1721..1744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1756..1795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..661
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1784
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 543
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 630
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 861
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18088087"
FT MOD_RES 1401
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 79..101
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15184363,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_010901"
FT VARIANT 171
FT /note="S -> T"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.2"
FT /id="VAR_019425"
FT VARIANT 277
FT /note="P -> A (in dbSNP:rs2298548)"
FT /id="VAR_026042"
FT VARIANT 307
FT /note="S -> C (de novo variant found in a patient with
FT childhood apraxia of speech; unknown pathological
FT significance)"
FT /evidence="ECO:0000269|PubMed:29463886"
FT /id="VAR_081528"
FT VARIANT 390
FT /note="E -> D (in dbSNP:rs35101529)"
FT /id="VAR_048271"
FT VARIANT 507
FT /note="T -> I (in dbSNP:rs17498752)"
FT /id="VAR_048272"
FT VARIANT 531
FT /note="T -> S (in dbSNP:rs7243088)"
FT /id="VAR_048273"
FT VARIANT 818
FT /note="S -> N (in dbSNP:rs2298546)"
FT /id="VAR_022088"
FT VARIANT 906
FT /note="K -> R (in dbSNP:rs4798791)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_024173"
FT VARIANT 998
FT /note="L -> S (in dbSNP:rs34996750)"
FT /id="VAR_048274"
FT VARIANT 1758
FT /note="S -> P (in dbSNP:rs3744822)"
FT /id="VAR_048275"
FT CONFLICT 604
FT /note="E -> K (in Ref. 5; CAH56382)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2062 AA; 235652 MW; 3CAFAA05E4AA1753 CRC64;
MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK EMKEKSSMKR
KLPFTISPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY SEKEGPEKKK TKKEAGNKKS
TPVSILFGYP LSERKQMALL MQMTARDNSP DSTPNHPSQT TPAQKKTPSS SSRQKDKVNK
RNERGETPLH MAAIRGDVKQ VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA
GADVNTQGLD DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL
KREVPLSDDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSL ICESKQILPS KTPLPSALDE
YEFKDDDDEE INKMIDDRHI LRKEQRKENE PEAEKTHLFA KQEKAFYPKS FKSKKQKPSR
VLYSSTESSD EEALQNKKIS TSCSVIPETS NSDMQTKKEY VVSGEHKQKG KVKRKLKNQN
KNKENQELKQ EKEGKENTRI TNLTVNTGLD CSEKTREEGN FRKSFSPKDD TSLHLFHIST
GKSPKHSCGL SEKQSTPLKQ EHTKTCLSPG SSEMSLQPDL VRYDNTESEF LPESSSVKSC
KHKEKSKHQK DFHLEFGEKS NAKIKDEDHS PTFENSDCTL KKMDKEGKTL KKHKLKHKER
EKEKHKKEIE GEKEKYKTKD SAKELQRSVE FDREFWKENF FKSDETEDLF LNMEHESLTL
EKKSKLEKNI KDDKSTKEKH VSKERNFKEE RDKIKKESEK SFREEKIKDL KEERENIPTD
KDSEFTSLGM SAIEESIGLH LVEKEIDIEK QEKHIKESKE KPEKRSQIKE KDIEKMERKT
FEKEKKIKHE HKSEKDKLDL SECVDKIKEK DKLYSHHTEK CHKEGEKSKN TAAIKKTDDR
EKSREKMDRK HDKEKPEKER HLAESKEKHL MEKKNKQSDN SEYSKSEKGK NKEKDRELDK
KEKSRDKESI NITNSKHIQE EKKSSIVDGN KAQHEKPLSL KEKTKDEPLK TPDGKEKDKK
DKDIDRYKER DKHKDKIQIN SLLKLKSEAD KPKPKSSPAS KDTRPKEKRL VNDDLMQTSF
ERMLSLKDLE IEQWHKKHKE KIKQKEKERL RNRNCLELKI KDKEKTKHTP TESKNKELTR
SKSSEVTDAY TKEKQPKDAV SNRSQSVDTK NVMTLGKSSF VSDNSLNRSP RSENEKPGLS
SRSVSMISVA SSEDSCHTTV TTPRPPVEYD SDFMLESSES QMSFSQSPFL SIAKSPALHE
RELDSLADLP ERIKPPYANR LSTSHLRSSS VEDVKLIISE GRPTIEVRRC SMPSVICEHT
KQFQTISEES NQGSLLTVPG DTSPSPKPEV FSNVPERDLS NVSNIHSSFA TSPTGASNSK
YVSADRNLIK NTAPVNTVMD SPVHLEPSSQ VGVIQNKSWE MPVDRLETLS TRDFICPNSN
IPDQESSLQS FCNSENKVLK ENADFLSLRQ TELPGNSCAQ DPASFMPPQQ PCSFPSQSLS
DAESISKHMS LSYVANQEPG ILQQKNAVQI ISSALDTDNE STKDTENTFV LGDVQKTDAF
VPVYSDSTIQ EASPNFEKAY TLPVLPSEKD FNGSDASTQL NTHYAFSKLT YKSSSGHEVE
NSTTDTQVIS HEKENKLESL VLTHLSRCDS DLCEMNAGMP KGNLNEQDPK HCPESEKCLL
SIEDEESQQS ILSSLENHSQ QSTQPEMHKY GQLVKVELEE NAEDDKTENQ IPQRMTRNKA
NTMANQSKQI LASCTLLSEK DSESSSPRGR IRLTEDDDPQ IHHPRKRKVS RVPQPVQVSP
SLLQAKEKTQ QSLAAIVDSL KLDEIQPYSS ERANPYFEYL HIRKKIEEKR KLLCSVIPQA
PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK ELFRQQEVVR MKLRLQHSIE
REKLIVSNEQ EVLRVHYRAA RTLANQTLPF SACTVLLDAE VYNVPLDSQS DDSKTSVRDR
FNARQFMSWL QDVDDKFDKL KTCLLMRQQH EAAALNAVQR LEWQLKLQEL DPATYKSISI
YEIQEFYVPL VDVNDDFELT PI
