ANR22_HUMAN
ID ANR22_HUMAN Reviewed; 191 AA.
AC Q5VYY1; B2R9Y7; Q8WU06;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ankyrin repeat domain-containing protein 22;
GN Name=ANKRD22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-73; HIS-79;
RP PRO-148 AND ILE-177.
RC TISSUE=Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK313969; BAG36684.1; -; mRNA.
DR EMBL; AL353113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL157394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW50159.1; -; Genomic_DNA.
DR EMBL; BC021671; AAH21671.1; -; mRNA.
DR CCDS; CCDS7390.1; -.
DR RefSeq; NP_653191.2; NM_144590.2.
DR AlphaFoldDB; Q5VYY1; -.
DR SMR; Q5VYY1; -.
DR BioGRID; 125627; 29.
DR IntAct; Q5VYY1; 2.
DR STRING; 9606.ENSP00000360998; -.
DR iPTMnet; Q5VYY1; -.
DR PhosphoSitePlus; Q5VYY1; -.
DR BioMuta; ANKRD22; -.
DR DMDM; 74747727; -.
DR EPD; Q5VYY1; -.
DR jPOST; Q5VYY1; -.
DR MassIVE; Q5VYY1; -.
DR MaxQB; Q5VYY1; -.
DR PaxDb; Q5VYY1; -.
DR PeptideAtlas; Q5VYY1; -.
DR PRIDE; Q5VYY1; -.
DR ProteomicsDB; 65657; -.
DR Antibodypedia; 2542; 107 antibodies from 17 providers.
DR DNASU; 118932; -.
DR Ensembl; ENST00000371930.5; ENSP00000360998.4; ENSG00000152766.6.
DR GeneID; 118932; -.
DR KEGG; hsa:118932; -.
DR MANE-Select; ENST00000371930.5; ENSP00000360998.4; NM_144590.3; NP_653191.2.
DR UCSC; uc001kfj.5; human.
DR CTD; 118932; -.
DR DisGeNET; 118932; -.
DR GeneCards; ANKRD22; -.
DR HGNC; HGNC:28321; ANKRD22.
DR HPA; ENSG00000152766; Tissue enhanced (esophagus, skin, stomach).
DR neXtProt; NX_Q5VYY1; -.
DR OpenTargets; ENSG00000152766; -.
DR PharmGKB; PA134954600; -.
DR VEuPathDB; HostDB:ENSG00000152766; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00390000009005; -.
DR HOGENOM; CLU_121978_0_0_1; -.
DR InParanoid; Q5VYY1; -.
DR OMA; ADPMIKN; -.
DR OrthoDB; 1514637at2759; -.
DR PhylomeDB; Q5VYY1; -.
DR TreeFam; TF332383; -.
DR PathwayCommons; Q5VYY1; -.
DR SignaLink; Q5VYY1; -.
DR BioGRID-ORCS; 118932; 11 hits in 1070 CRISPR screens.
DR ChiTaRS; ANKRD22; human.
DR GenomeRNAi; 118932; -.
DR Pharos; Q5VYY1; Tbio.
DR PRO; PR:Q5VYY1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5VYY1; protein.
DR Bgee; ENSG00000152766; Expressed in upper arm skin and 136 other tissues.
DR Genevisible; Q5VYY1; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR042802; ANR22.
DR PANTHER; PTHR47276; PTHR47276; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..191
FT /note="Ankyrin repeat domain-containing protein 22"
FT /id="PRO_0000240838"
FT REPEAT 39..68
FT /note="ANK 1"
FT REPEAT 72..100
FT /note="ANK 2"
FT REPEAT 101..130
FT /note="ANK 3"
FT REPEAT 134..163
FT /note="ANK 4"
FT VARIANT 73
FT /note="E -> G (in dbSNP:rs17113412)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027628"
FT VARIANT 79
FT /note="Y -> H (in dbSNP:rs17851907)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027629"
FT VARIANT 148
FT /note="Q -> P (in dbSNP:rs2304804)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027630"
FT VARIANT 177
FT /note="R -> I (in dbSNP:rs7912706)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027631"
SQ SEQUENCE 191 AA; 21849 MW; 6F997DAEDB97161D CRC64;
MGILYSEPIC QAAYQNDFGQ VWRWVKEDSS YANVQDGFNG DTPLICACRR GHVRIVSFLL
RRNANVNLKN QKERTCLHYA VKKKFTFIDY LLIILLMPVL LIGYFLMVSK TKQNEALVRM
LLDAGVEVNA TDCYGCTALH YACEMKNQSL IPLLLEARAD PTIKNKHGES SLDIARRLKF
SQIELMLRKA L
