ID   ANR23_MOUSE             Reviewed;         306 AA.
AC   Q812A3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Ankyrin repeat domain-containing protein 23;
DE   AltName: Full=Diabetes-related ankyrin repeat protein;
GN   Name=Ankrd23; Synonyms=Darp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=12456686; DOI=10.1074/jbc.m204563200;
RA   Ikeda K., Emoto N., Matsuo M., Yokoyama M.;
RT   "Molecular identification and characterization of a novel nuclear protein
RT   whose expression is up-regulated in insulin-resistant animals.";
RL   J. Biol. Chem. 278:3514-3520(2003).
CC   -!- FUNCTION: May be involved in the energy metabolism. Could be a
CC       molecular link between myofibrillar stretch-induced signaling pathways
CC       and muscle gene expression.
CC   -!- SUBUNIT: Interacts with titin/TTN and MYPN. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Sarcomeric I-band and some
CC       intercalated disks. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF492400; AAO24066.1; -; mRNA.
DR   CCDS; CCDS14882.1; -.
DR   RefSeq; NP_001297450.1; NM_001310521.1.
DR   RefSeq; NP_705722.2; NM_153502.4.
DR   AlphaFoldDB; Q812A3; -.
DR   SMR; Q812A3; -.
DR   STRING; 10090.ENSMUSP00000061168; -.
DR   iPTMnet; Q812A3; -.
DR   PhosphoSitePlus; Q812A3; -.
DR   PaxDb; Q812A3; -.
DR   PRIDE; Q812A3; -.
DR   ProteomicsDB; 281997; -.
DR   DNASU; 78321; -.
DR   Ensembl; ENSMUST00000054665; ENSMUSP00000061168; ENSMUSG00000067653.
DR   GeneID; 78321; -.
DR   KEGG; mmu:78321; -.
DR   UCSC; uc007aql.1; mouse.
DR   CTD; 200539; -.
DR   MGI; MGI:1925571; Ankrd23.
DR   VEuPathDB; HostDB:ENSMUSG00000067653; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000161920; -.
DR   HOGENOM; CLU_000134_11_2_1; -.
DR   InParanoid; Q812A3; -.
DR   OMA; QNEASMT; -.
DR   OrthoDB; 1514637at2759; -.
DR   PhylomeDB; Q812A3; -.
DR   TreeFam; TF331650; -.
DR   BioGRID-ORCS; 78321; 1 hit in 75 CRISPR screens.
DR   ChiTaRS; Ankrd23; mouse.
DR   PRO; PR:Q812A3; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q812A3; protein.
DR   Bgee; ENSMUSG00000067653; Expressed in quadriceps femoris and 60 other tissues.
DR   ExpressionAtlas; Q812A3; baseline and differential.
DR   Genevisible; Q812A3; MM.
DR   GO; GO:0015629; C:actin cytoskeleton; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0031674; C:I band; IDA:MGI.
DR   GO; GO:0014704; C:intercalated disc; ISO:MGI.
DR   GO; GO:0030016; C:myofibril; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0031432; F:titin binding; ISO:MGI.
DR   GO; GO:0006631; P:fatty acid metabolic process; IDA:MGI.
DR   GO; GO:0060297; P:regulation of sarcomere organization; IGI:MGI.
DR   GO; GO:0035994; P:response to muscle stretch; IGI:MGI.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR028780; ANKRD23.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24126:SF45; PTHR24126:SF45; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..306
FT                   /note="Ankyrin repeat domain-containing protein 23"
FT                   /id="PRO_0000240667"
FT   REPEAT          144..173
FT                   /note="ANK 1"
FT   REPEAT          177..206
FT                   /note="ANK 2"
FT   REPEAT          210..239
FT                   /note="ANK 3"
FT   REPEAT          243..272
FT                   /note="ANK 4"
FT   REGION          78..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..196
FT                   /note="Interaction with TTN"
FT                   /evidence="ECO:0000250"
FT   COILED          41..90
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   306 AA;  34348 MW;  A78D074B43C8C88A CRC64;
     MDFISIEQLV SGERVDRKAL EFGRGVPDPG GWPSGWTLGP QEAVAREKLK LEEEKRKKLE
     RFNSSRLTLD NLTDLENLVQ RRRKKRQRHK VPPREPESGA EPQPQVPLEP VGLEMFLKAA
     AENQEALIDK YLADGGDPNA HDKLHRTALH WACLKGHRQL VNKLLAAGAA IEVRDLLDRT
     PVFWACRGGH LDILKRLLNQ GAQVNAQDKI WSTPLHVAVR MGHSDCLEHL IECGAHINAQ
     DKEGDTALHE AVRYGHHKAT KLLLLYGAKL GVKNVASQTP VQLARDWQRG IRDALQAHVG
     HPRTRC