ANR24_MOUSE
ID ANR24_MOUSE Reviewed; 985 AA.
AC Q80VM7; E9QJV7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 4.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ankyrin repeat domain-containing protein 24;
GN Name=Ankrd24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AC153919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048236; AAH48236.3; -; mRNA.
DR CCDS; CCDS36001.1; -.
DR RefSeq; NP_081756.4; NM_027480.3.
DR RefSeq; XP_006514161.1; XM_006514098.3.
DR AlphaFoldDB; Q80VM7; -.
DR SMR; Q80VM7; -.
DR BioGRID; 214167; 1.
DR STRING; 10090.ENSMUSP00000112932; -.
DR PhosphoSitePlus; Q80VM7; -.
DR PaxDb; Q80VM7; -.
DR PRIDE; Q80VM7; -.
DR ProteomicsDB; 281998; -.
DR Antibodypedia; 53380; 16 antibodies from 10 providers.
DR DNASU; 70615; -.
DR Ensembl; ENSMUST00000119336; ENSMUSP00000112932; ENSMUSG00000054708.
DR GeneID; 70615; -.
DR KEGG; mmu:70615; -.
DR UCSC; uc007gjd.1; mouse.
DR CTD; 170961; -.
DR MGI; MGI:1890394; Ankrd24.
DR VEuPathDB; HostDB:ENSMUSG00000054708; -.
DR eggNOG; ENOG502QQ0K; Eukaryota.
DR GeneTree; ENSGT00940000159237; -.
DR HOGENOM; CLU_005323_0_0_1; -.
DR InParanoid; Q80VM7; -.
DR OMA; GPMEMEL; -.
DR OrthoDB; 876605at2759; -.
DR PhylomeDB; Q80VM7; -.
DR TreeFam; TF331274; -.
DR BioGRID-ORCS; 70615; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Ankrd24; mouse.
DR PRO; PR:Q80VM7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q80VM7; protein.
DR Bgee; ENSMUSG00000054708; Expressed in motor neuron and 239 other tissues.
DR ExpressionAtlas; Q80VM7; baseline and differential.
DR Genevisible; Q80VM7; MM.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 2: Evidence at transcript level;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..985
FT /note="Ankyrin repeat domain-containing protein 24"
FT /id="PRO_0000328837"
FT REPEAT 52..81
FT /note="ANK 1"
FT REPEAT 85..114
FT /note="ANK 2"
FT REPEAT 118..147
FT /note="ANK 3"
FT REPEAT 151..180
FT /note="ANK 4"
FT REPEAT 184..213
FT /note="ANK 5"
FT REGION 243..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 291..488
FT /evidence="ECO:0000255"
FT COMPBIAS 243..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 391
FT /note="E -> G (in Ref. 2; AAH48236)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 985 AA; 106238 MW; CA2490ED495270D4 CRC64;
MKTLRARFKK TEGQDWGKSD QRLLQAVENN DVARVASLIA HKGLVPTKLD PEGKSAFHLA
AMRGAAGCLE VMLAQGADVM STDGAGYNAL HLAAKYGHPE CLKQLLEASC VVDIEDSSGW
TALHHAAAGG CLSCSKLLCS FKAHMNPRDR SGATPLIIAA QMCHTDLCRL LLQQGAATND
QDLQGRTALM LACEGGSPET VEVLLQGGAQ LSITDALGQD ATHYGALTGD KLILQLLHES
ARRSSPPSAS LEEDSGEASS QNSVSSHEKQ GAPKKRKAPQ PPASTPVPDD RDAYEEIVRL
RQERGRLLQK IRGLEQHKER RRKEPLEAEA SSVHSLERQV QELQQMLAEK QEEKESLGRE
VESLQSRLSL LENERENTSY DVATLQDEEG EMPDFPGADA LMPKNQSPSA EEIVASLQEQ
VAQLTRQNQE LLEKVQILEE FEKDEAQMAE ESQAEVVPLV LYESLRAELE QLRRQYTEAM
HSQQQQQEGE PPRAQEGEET AYQEIKDKGI TIQNGPSVPD LNGTTYAETK ANGMELQAGG
SKGVWNTEAG VSEAAPIEPE AAGSEATGKD RLAAKEMDTS ATMAEALNVK ALGDNAESEP
VAAEDTGGKE NPGMKADEVD VLAQAGLTGT VIRNMEAIGV RDTGIQATGL EAKAVKTTGV
QATVAEVIGV KVTGVQTTAI EAIGVKDTTQ VATGAQADCW QATEADCTGA QDTAMEPTGA
QATVTETTEA ETSGTEDPCA AILHPGAAAA ALQAELETRI RGLEEALRRR EREAAAELEA
ARGRFAEAEE AARGRSRELE ALRELLATAT ATGERARTEA AELRQALAAS EARVAELSST
VDAAREELER MRGASVPADE HEHALSALRD HVTRLQAQLA DLARRHEKTS AEVFQITDLS
KEVFTLKEAL KVQQSTPASS KEEEALRGQV TALQQQIQEE AREHGAVVAL YRTHLLYAIQ
GQMDEDVQCI LSQILQMQRL QAQGR
