ANR26_HUMAN
ID ANR26_HUMAN Reviewed; 1710 AA.
AC Q9UPS8; A6NH29; Q2TAZ3; Q6ZR14; Q9H1Q1; Q9NSK9; Q9NTD5; Q9NW69;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 4.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Ankyrin repeat domain-containing protein 26 {ECO:0000305};
GN Name=ANKRD26 {ECO:0000312|HGNC:HGNC:29186}; Synonyms=KIAA1074;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-20.
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1522 (ISOFORM 2), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-546 (ISOFORM 1), AND VARIANTS ARG-20;
RP SER-606 DEL; ILE-1305 AND LEU-1514.
RC TISSUE=Embryo, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1338-1710.
RC TISSUE=Melanoma, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1546-1710.
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [7]
RP IDENTIFICATION.
RX PubMed=16364570; DOI=10.1016/j.gene.2005.07.045;
RA Hahn Y., Bera T.K., Pastan I.H., Lee B.;
RT "Duplication and extensive remodeling shaped POTE family genes encoding
RT proteins containing ankyrin repeat and coiled coil domains.";
RL Gene 366:238-245(2006).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP INVOLVEMENT IN THC2.
RX PubMed=21211618; DOI=10.1016/j.ajhg.2010.12.006;
RA Pippucci T., Savoia A., Perrotta S., Pujol-Moix N., Noris P.,
RA Castegnaro G., Pecci A., Gnan C., Punzo F., Marconi C., Gherardi S.,
RA Loffredo G., De Rocco D., Scianguetta S., Barozzi S., Magini P., Bozzi V.,
RA Dezzani L., Di Stazio M., Ferraro M., Perini G., Seri M., Balduini C.L.;
RT "Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene,
RT cause an autosomal-dominant form of inherited thrombocytopenia, THC2.";
RL Am. J. Hum. Genet. 88:115-120(2011).
RN [11]
RP INTERACTION WITH TRIO; CCDC85B; GPS2 AND HMMR.
RX PubMed=22666460; DOI=10.1371/journal.pone.0038130;
RA Liu X.F., Bera T.K., Kahue C., Escobar T., Fei Z., Raciti G.A., Pastan I.;
RT "ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate
RT adipogenesis in 3T3-L1 cells.";
RL PLoS ONE 7:E38130-E38130(2012).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-15; SER-261; SER-489;
RP SER-530 AND SER-631, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Acts as a regulator of adipogenesis. Involved in the
CC regulation of the feeding behavior. {ECO:0000250|UniProtKB:Q811D2}.
CC -!- SUBUNIT: Interacts with TRIO (PubMed:22666460). Interacts with GPS2
CC (PubMed:22666460). Interacts with CCDC85B (PubMed:22666460). Interacts
CC with HMMR (PubMed:22666460). {ECO:0000269|PubMed:22666460}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UPS8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UPS8-2; Sequence=VSP_019434, VSP_019435;
CC -!- DISEASE: Thrombocytopenia 2 (THC2) [MIM:188000]: A form of
CC thrombocytopenia, a hematologic disorder defined by a decrease in the
CC number of platelets in circulating blood, resulting in the potential
CC for increased bleeding and decreased ability for clotting.
CC {ECO:0000269|PubMed:21211618}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA83026.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB028997; BAA83026.2; ALT_INIT; mRNA.
DR EMBL; AL162272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK001137; BAA91516.1; -; mRNA.
DR EMBL; AK128577; BAC87508.1; -; mRNA.
DR EMBL; AL137351; CAB70706.1; -; mRNA.
DR EMBL; AL162063; CAB82401.1; -; mRNA.
DR EMBL; BC110646; AAI10647.1; -; mRNA.
DR CCDS; CCDS41499.1; -. [Q9UPS8-1]
DR PIR; T46425; T46425.
DR PIR; T47167; T47167.
DR RefSeq; NP_001242982.1; NM_001256053.1.
DR RefSeq; NP_055730.2; NM_014915.2. [Q9UPS8-1]
DR AlphaFoldDB; Q9UPS8; -.
DR SMR; Q9UPS8; -.
DR BioGRID; 116523; 97.
DR IntAct; Q9UPS8; 23.
DR MINT; Q9UPS8; -.
DR STRING; 9606.ENSP00000365255; -.
DR GlyGen; Q9UPS8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9UPS8; -.
DR PhosphoSitePlus; Q9UPS8; -.
DR BioMuta; ANKRD26; -.
DR DMDM; 109940217; -.
DR EPD; Q9UPS8; -.
DR jPOST; Q9UPS8; -.
DR MassIVE; Q9UPS8; -.
DR MaxQB; Q9UPS8; -.
DR PaxDb; Q9UPS8; -.
DR PeptideAtlas; Q9UPS8; -.
DR PRIDE; Q9UPS8; -.
DR ProteomicsDB; 85431; -. [Q9UPS8-1]
DR ProteomicsDB; 85432; -. [Q9UPS8-2]
DR Antibodypedia; 25959; 132 antibodies from 25 providers.
DR DNASU; 22852; -.
DR Ensembl; ENST00000376087.5; ENSP00000365255.4; ENSG00000107890.17. [Q9UPS8-1]
DR GeneID; 22852; -.
DR KEGG; hsa:22852; -.
DR MANE-Select; ENST00000376087.5; ENSP00000365255.4; NM_014915.3; NP_055730.2.
DR UCSC; uc009xku.2; human. [Q9UPS8-1]
DR CTD; 22852; -.
DR DisGeNET; 22852; -.
DR GeneCards; ANKRD26; -.
DR GeneReviews; ANKRD26; -.
DR HGNC; HGNC:29186; ANKRD26.
DR HPA; ENSG00000107890; Low tissue specificity.
DR MalaCards; ANKRD26; -.
DR MIM; 188000; phenotype.
DR MIM; 610855; gene.
DR neXtProt; NX_Q9UPS8; -.
DR OpenTargets; ENSG00000107890; -.
DR Orphanet; 168629; Autosomal thrombocytopenia with normal platelets.
DR Orphanet; 71290; Familial platelet disorder with associated myeloid malignancy.
DR PharmGKB; PA134926710; -.
DR VEuPathDB; HostDB:ENSG00000107890; -.
DR eggNOG; ENOG502QR0R; Eukaryota.
DR GeneTree; ENSGT00940000162459; -.
DR HOGENOM; CLU_001111_0_0_1; -.
DR InParanoid; Q9UPS8; -.
DR OMA; RKCEIDA; -.
DR OrthoDB; 305292at2759; -.
DR PhylomeDB; Q9UPS8; -.
DR TreeFam; TF333496; -.
DR PathwayCommons; Q9UPS8; -.
DR Reactome; R-HSA-9696264; RND3 GTPase cycle.
DR Reactome; R-HSA-9696270; RND2 GTPase cycle.
DR Reactome; R-HSA-9696273; RND1 GTPase cycle.
DR SignaLink; Q9UPS8; -.
DR SIGNOR; Q9UPS8; -.
DR BioGRID-ORCS; 22852; 7 hits in 1082 CRISPR screens.
DR ChiTaRS; ANKRD26; human.
DR GeneWiki; ANKRD26; -.
DR GenomeRNAi; 22852; -.
DR Pharos; Q9UPS8; Tbio.
DR PRO; PR:Q9UPS8; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9UPS8; protein.
DR Bgee; ENSG00000107890; Expressed in calcaneal tendon and 125 other tissues.
DR ExpressionAtlas; Q9UPS8; baseline and differential.
DR Genevisible; Q9UPS8; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR InterPro; IPR021885; DUF3496.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF14915; CCDC144C; 1.
DR Pfam; PF12001; DUF3496; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Coiled coil; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..1710
FT /note="Ankyrin repeat domain-containing protein 26"
FT /id="PRO_0000240843"
FT REPEAT 45..75
FT /note="ANK 1"
FT REPEAT 79..108
FT /note="ANK 2"
FT REPEAT 112..141
FT /note="ANK 3"
FT REPEAT 145..174
FT /note="ANK 4"
FT REPEAT 178..207
FT /note="ANK 5"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 529..566
FT /evidence="ECO:0000255"
FT COILED 743..873
FT /evidence="ECO:0000255"
FT COILED 905..1472
FT /evidence="ECO:0000255"
FT COILED 1517..1587
FT /evidence="ECO:0000255"
FT COILED 1649..1674
FT /evidence="ECO:0000255"
FT COMPBIAS 230..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q811D2"
FT MOD_RES 261
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 489
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 530
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 631
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..443
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019434"
FT VAR_SEQ 444..545
FT /note="KEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLH
FT LKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQ -> MNHMF
FT HIKRHSISAGTDAYKKTKPIQNLFQKPLYDHCSANNYKSMEPELENVRSSPPRGDRTSK
FT VSLKEELQQDMQRFKNEIGMLKVEFQALEKEKVQLQKE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019435"
FT VARIANT 20
FT /note="Q -> R (in dbSNP:rs7897309)"
FT /evidence="ECO:0000269|PubMed:10470851,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_026833"
FT VARIANT 425
FT /note="I -> V (in dbSNP:rs12359281)"
FT /id="VAR_055513"
FT VARIANT 606
FT /note="Missing (in dbSNP:rs564681878)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_080646"
FT VARIANT 1220
FT /note="V -> L (in dbSNP:rs12572862)"
FT /id="VAR_055514"
FT VARIANT 1305
FT /note="V -> I (in dbSNP:rs10829163)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026834"
FT VARIANT 1514
FT /note="F -> L (in dbSNP:rs2274741)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026835"
FT CONFLICT 1347
FT /note="D -> G (in Ref. 3; BAC87508)"
FT /evidence="ECO:0000305"
FT CONFLICT 1517..1523
FT /note="NNFASMK -> KQDLPDS (in Ref. 3; BAC87508)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1710 AA; 196411 MW; 01CBF9BADB894872 CRC64;
MKKIFSKKGE SPLGSFARRQ RSSAGGGGEP GEGAYSQPGY HVRDRDLGKI HKAASAGNVA
KVQQILLLRK NGLNDRDKMN RTALHLACAN GHPEVVTLLV DRKCQLNVCD NENRTALMKA
VQCQEEKCAT ILLEHGADPN LADVHGNTAL HYAVYNEDIS VATKLLLYDA NIEAKNKDDL
TPLLLAVSGK KQQMVEFLIK KKANVNAVDK LESSHQLISE YKEERIPKHS SQNSNSVDES
SEDSLSRLSG KPGVDDSWPT SDDEDLNFDT KNVPKPSLAK LMTASQQSRK NLEATYGTVR
TGNRTLFEDR DSDSQDEVVV ESLPTTSIKV QCFSHPTYQS PDLLPKPSHK SLANPGLMKE
EPTKPGIAKK ENGIDIIESA PLEQTNNDNL TYVDEVHKNN RSDMMSALGL GQEEDIESPW
DSESISENFP QKYVDPLAGA ADGKEKNIGN EQAEDVFYIP SCMSGSRNFK MAKLEDTRNV
GMPVAHMESP ERYLHLKPTI EMKDSVPNKA GGMKDVQTSK AAEHDLEVAS EEEQEREGSE
NNQPQVEEER KKHRNNEMEV SANIHDGATD DAEDDDDDDG LIQKRKSGET DHQQFPRKEN
KEYASSGPAL QMKEVKSTEK EKRTSKESVN SPVFGKASLL TGGLLQVDDD SSLSEIDEDE
GRPTKKTSNE KNKVKNQIQS MDDVDDLTQS SETASEDCEL PHSSYKNFML LIEQLGMECK
DSVSLLKIQD AALSCERLLE LKKNHCELLT VKIKKMEDKV NVLQRELSET KEIKSQLEHQ
KVEWERELCS LRFSLNQEEE KRRNADTLYE KIREQLRRKE EQYRKEVEVK QQLELSLQTL
EMELRTVKSN LNQVVQERND AQRQLSREQN ARMLQDGILT NHLSKQKEIE MAQKKMNSEN
SHSHEEEKDL SHKNSMLQEE IAMLRLEIDT IKNQNQEKEK KCFEDLKIVK EKNEDLQKTI
KQNEETLTQT ISQYNGRLSV LTAENAMLNS KLENEKQSKE RLEAEVESYH SRLAAAIHDR
DQSETSKREL ELAFQRARDE CSRLQDKMNF DVSNLKDNNE ILSQQLFKTE SKLNSLEIEF
HHTRDALREK TLGLERVQKD LSQTQCQMKE MEQKYQNEQV KVNKYIGKQE SVEERLSQLQ
SENMLLRQQL DDAHNKADNK EKTVINIQDQ FHAIVQKLQA ESEKQSLLLE ERNKELISEC
NHLKERQYQY ENEKAEREVV VRQLQQELAD TLKKQSMSEA SLEVTSRYRI NLEDETQDLK
KKLGQIRNQL QEAQDRHTEA VRCAEKMQDH KQKLEKDNAK LKVTVKKQMD KIEELQKNLL
NANLSEDEKE QLKKLMELKQ SLECNLDQEM KKNVELEREI TGFKNLLKMT RKKLNEYENG
EFSFHGDLKT SQFEMDIQIN KLKHKIDDLT AELETAGSKC LHLDTKNQIL QEELLSMKTV
QKKCEKLQKN KKKLEQEVIN LRSHIERNMV ELGQVKQYKQ EIEERARQEI AEKLKEVNLF
LQAQAASQEN LEQFRENNFA SMKSQMELRI KDLESELSKI KTSQEDFNKT ELEKYKQLYL
EELKVRKSLS SKLTKTNERL AEVNTKLLVE KQQSRSLFTT LTTRPVMEPP CVGNLNNSLD
LNRKLIPREN LVISTSNPRA SNNSMENYLS KMQQELEKNI TRELKEAAAE LESGSIASPL
GSTDESNLNQ DLVWKASREY VQVLKKNYMI
