位置:首页 > 蛋白库 > HIS6_SALTY
HIS6_SALTY
ID   HIS6_SALTY              Reviewed;         258 AA.
AC   P0A1R2; P10374;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Imidazole glycerol phosphate synthase subunit HisF;
DE            EC=4.3.2.10;
DE   AltName: Full=IGP synthase cyclase subunit;
DE   AltName: Full=IGP synthase subunit HisF;
DE   AltName: Full=ImGP synthase subunit HisF;
DE            Short=IGPS subunit HisF;
GN   Name=hisF; OrderedLocusNames=STM2077;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=3062174; DOI=10.1016/0022-2836(88)90194-5;
RA   Carlomagno M.S., Chiariotti L., Alifano P., Nappo A.G., Bruni C.B.;
RT   "Structure and function of the Salmonella typhimurium and Escherichia coli
RT   K-12 histidine operons.";
RL   J. Mol. Biol. 203:585-606(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP,
CC       AICAR and glutamate. The HisF subunit catalyzes the cyclization
CC       activity that produces IGP and AICAR from PRFAR using the ammonia
CC       provided by the HisH subunit (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-
CC         phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-
CC         amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-
CC         erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate;
CC         Xref=Rhea:RHEA:24793, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58278, ChEBI:CHEBI:58359, ChEBI:CHEBI:58475,
CC         ChEBI:CHEBI:58525; EC=4.3.2.10;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
CC   -!- SUBUNIT: Heterodimer of HisH and HisF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the HisA/HisF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X13464; CAA31828.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20981.1; -; Genomic_DNA.
DR   PIR; JS0162; OYEBHF.
DR   RefSeq; NP_461022.1; NC_003197.2.
DR   RefSeq; WP_000880125.1; NC_003197.2.
DR   AlphaFoldDB; P0A1R2; -.
DR   SMR; P0A1R2; -.
DR   STRING; 99287.STM2077; -.
DR   PaxDb; P0A1R2; -.
DR   EnsemblBacteria; AAL20981; AAL20981; STM2077.
DR   GeneID; 1253598; -.
DR   KEGG; stm:STM2077; -.
DR   PATRIC; fig|99287.12.peg.2199; -.
DR   HOGENOM; CLU_048577_4_0_6; -.
DR   OMA; IFHYKET; -.
DR   PhylomeDB; P0A1R2; -.
DR   BioCyc; SENT99287:STM2077-MON; -.
DR   UniPathway; UPA00031; UER00010.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000107; F:imidazoleglycerol-phosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04731; HisF; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01013; HisF; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006062; His_biosynth.
DR   InterPro; IPR004651; HisF.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00977; His_biosynth; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR00735; hisF; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis; Lyase;
KW   Reference proteome.
FT   CHAIN           1..258
FT                   /note="Imidazole glycerol phosphate synthase subunit HisF"
FT                   /id="PRO_0000142225"
FT   ACT_SITE        11
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        130
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   258 AA;  28368 MW;  B60BB8BC2514E462 CRC64;
     MLAKRIIPCL DVRDGQVVKG VQFRNHEIIG DIVPLAKRYA DEGADELVFY DITASSDGRV
     VDKSWVARVA EVIDIPFCVA GGIRSIDDAA KILSFGADKI SINSPALADP TLITRLADRF
     GVQCIVVGID TWFDDATGKY HVNQYTGDEN RTRVTQWETL DWVQEVQQRG AGEIVLNMMN
     QDGVRNGYDL TQLKKVRDVC RVPLIASGGA GTMEHFLEAF RDADVDGALA ASVFHKQIIN
     IGELKAYLAG QGVEIRIC
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024