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ANR28_MOUSE
ID   ANR28_MOUSE             Reviewed;        1053 AA.
AC   Q505D1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A;
DE            Short=PP6-ARS-A;
DE            Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A;
DE   AltName: Full=Ankyrin repeat domain-containing protein 28;
DE   AltName: Full=Phosphatase interactor targeting protein hnRNP K;
DE            Short=PITK;
GN   Name=Ankrd28;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=16564677; DOI=10.1016/j.cellsig.2006.01.019;
RA   Kwiek N.C., Thacker D.F., Datto M.B., Megosh H.B., Haystead T.A.J.;
RT   "PITK, a PP1 targeting subunit that modulates the phosphorylation of the
RT   transcriptional regulator hnRNP K.";
RL   Cell. Signal. 18:1769-1778(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1011, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6)
CC       that may be involved in the recognition of phosphoprotein substrates.
CC       Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its
CC       degradation in response to TNF-alpha. Selectively inhibits the
CC       phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK
CC       phosphorylation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a
CC       heterotrimeric complex formed by the catalytic subunit, a SAPS domain-
CC       containing subunit (PP6R) and an ankyrin repeat-domain containing
CC       regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts
CC       with PPP6C, PPP6R1 and PPP6R3 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Note=Seems to be excluded
CC       from nucleoli. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed (at protein level).
CC       {ECO:0000269|PubMed:16564677}.
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DR   EMBL; BC094609; AAH94609.1; -; mRNA.
DR   EMBL; BC051456; AAH51456.1; -; mRNA.
DR   CCDS; CCDS36858.1; -.
DR   RefSeq; NP_001019775.1; NM_001024604.2.
DR   AlphaFoldDB; Q505D1; -.
DR   SMR; Q505D1; -.
DR   BioGRID; 222872; 11.
DR   IntAct; Q505D1; 12.
DR   STRING; 10090.ENSMUSP00000014640; -.
DR   iPTMnet; Q505D1; -.
DR   PhosphoSitePlus; Q505D1; -.
DR   EPD; Q505D1; -.
DR   jPOST; Q505D1; -.
DR   MaxQB; Q505D1; -.
DR   PaxDb; Q505D1; -.
DR   PeptideAtlas; Q505D1; -.
DR   PRIDE; Q505D1; -.
DR   ProteomicsDB; 296256; -.
DR   Antibodypedia; 26857; 113 antibodies from 22 providers.
DR   DNASU; 105522; -.
DR   Ensembl; ENSMUST00000014640; ENSMUSP00000014640; ENSMUSG00000014496.
DR   GeneID; 105522; -.
DR   KEGG; mmu:105522; -.
DR   UCSC; uc007sxz.1; mouse.
DR   CTD; 23243; -.
DR   MGI; MGI:2145661; Ankrd28.
DR   VEuPathDB; HostDB:ENSMUSG00000014496; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00950000182908; -.
DR   HOGENOM; CLU_000134_58_0_1; -.
DR   InParanoid; Q505D1; -.
DR   OMA; YNGHLEM; -.
DR   PhylomeDB; Q505D1; -.
DR   TreeFam; TF312824; -.
DR   Reactome; R-MMU-171319; Telomere Extension By Telomerase.
DR   Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR   BioGRID-ORCS; 105522; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Ankrd28; mouse.
DR   PRO; PR:Q505D1; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q505D1; protein.
DR   Bgee; ENSMUSG00000014496; Expressed in plantaris and 255 other tissues.
DR   ExpressionAtlas; Q505D1; baseline and differential.
DR   Genevisible; Q505D1; MM.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 11.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF12796; Ank_2; 8.
DR   Pfam; PF13637; Ank_4; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 28.
DR   SUPFAM; SSF48403; SSF48403; 4.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 24.
PE   1: Evidence at protein level;
KW   ANK repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..1053
FT                   /note="Serine/threonine-protein phosphatase 6 regulatory
FT                   ankyrin repeat subunit A"
FT                   /id="PRO_0000244571"
FT   REPEAT          40..69
FT                   /note="ANK 1"
FT   REPEAT          73..102
FT                   /note="ANK 2"
FT   REPEAT          106..135
FT                   /note="ANK 3"
FT   REPEAT          139..168
FT                   /note="ANK 4"
FT   REPEAT          172..201
FT                   /note="ANK 5"
FT   REPEAT          205..234
FT                   /note="ANK 6"
FT   REPEAT          238..267
FT                   /note="ANK 7"
FT   REPEAT          271..301
FT                   /note="ANK 8"
FT   REPEAT          305..334
FT                   /note="ANK 9"
FT   REPEAT          338..367
FT                   /note="ANK 10"
FT   REPEAT          371..400
FT                   /note="ANK 11"
FT   REPEAT          404..433
FT                   /note="ANK 12"
FT   REPEAT          437..466
FT                   /note="ANK 13"
FT   REPEAT          470..500
FT                   /note="ANK 14"
FT   REPEAT          504..534
FT                   /note="ANK 15"
FT   REPEAT          549..578
FT                   /note="ANK 16"
FT   REPEAT          582..611
FT                   /note="ANK 17"
FT   REPEAT          616..645
FT                   /note="ANK 18"
FT   REPEAT          652..681
FT                   /note="ANK 19"
FT   REPEAT          685..714
FT                   /note="ANK 20"
FT   REPEAT          718..747
FT                   /note="ANK 21"
FT   REPEAT          755..786
FT                   /note="ANK 22"
FT   REPEAT          788..817
FT                   /note="ANK 23"
FT   REPEAT          822..851
FT                   /note="ANK 24"
FT   REPEAT          855..885
FT                   /note="ANK 25"
FT   REPEAT          889..918
FT                   /note="ANK 26"
FT   REPEAT          925..954
FT                   /note="ANK 27"
FT   MOD_RES         1007
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O15084"
FT   MOD_RES         1011
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   1053 AA;  112898 MW;  D7649AF1D1F22F62 CRC64;
     MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY LGDAEIIELL
     ILSGARVNAK DSKWLTPLHR AVASCSEEAV QILLKHSADV NARDKNWQTP LHIAAANKAV
     KCAESLVPLL SNVNVSDRAG RTALHHAAFS GHGEMVKLLL SRGANINAFD KKDRRAIHWA
     AYMGHIEVVK LLVSHGAEVT CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN
     TPLHVACYNG QDVVVNELID CGANVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN
     MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG HELLINTLIT
     SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT PDDFGRTCLH AAAAGGNLEC
     LNLLLNTGAD FNKKDKFGRS PLHYAAANCN YQCLFALVGS GASVNDLDER GCTPLHYAAT
     SDTDGKCLEY LLRNDANPGI RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD
     MLSDSDNRAT ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD
     VLINQGASIL VKDYVLKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD GNGQTPLMLS
     VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE CVDALLQHGA KCLLRDSRGR
     TPIHLSAACG HIGVLGALLQ SATSVDANPA VVDNHGYTAL HWACYNGHET CVELLLEQDV
     FQKIDGNAFS PLHCAVINDN EGAAEMLIDS LGASIVNATD SKGRTPLHAA AFTDHVECLQ
     LLLSQNAQVN SADSTGKTPL MMAAENGQTN TVEMLVSSAS ADLTLQDKSK NTALHLACGK
     GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA SVLAVDENGY
     TPALACAPNK DVADCLALIL ATMMPVSSSS PLTSLTFNAI NRYTNTSKTV SFEALPIMRN
     EASSYCSFNN IGGEQEYLYT DVDELNDSDS ETY
 
 
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