ID   ANR37_HUMAN             Reviewed;         158 AA.
AC   Q7Z713;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Ankyrin repeat domain-containing protein 37 {ECO:0000305};
DE   AltName: Full=Low-density lipoprotein receptor-related protein 2-binding protein {ECO:0000303|PubMed:15809689};
DE            Short=hLrp2bp {ECO:0000303|PubMed:15809689};
GN   Name=ANKRD37 {ECO:0000312|HGNC:HGNC:29593};
GN   Synonyms=LPR2BP {ECO:0000303|PubMed:15809689};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Brain;
RX   PubMed=15809689;
RA   Li J., Ji C., Zheng H., Fei X., Zheng M., Dai J., Gu S., Xie Y., Mao Y.;
RT   "Molecular cloning and characterization of a novel human gene containing 4
RT   ankyrin repeat domains.";
RL   Cell. Mol. Biol. Lett. 10:185-193(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q7Z713; Q9NWT6: HIF1AN; NbExp=7; IntAct=EBI-12373689, EBI-745632;
CC       Q7Z713; P36508: ZNF76; NbExp=3; IntAct=EBI-12373689, EBI-7254550;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15809689}. Cytoplasm
CC       {ECO:0000269|PubMed:15809689}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in testis, small intestine, colon,
CC       blood leukocytes and in pancreatic adenocarcinoma cells.
CC       {ECO:0000269|PubMed:15809689}.
CC   -!- PTM: Ubiquitinated by the CRL2(FEM1B) complex, leading to its
CC       degradation. {ECO:0000250|UniProtKB:Q569N2}.
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DR   EMBL; AY296056; AAP50252.1; -; mRNA.
DR   EMBL; BC088376; AAH88376.1; -; mRNA.
DR   CCDS; CCDS3841.1; -.
DR   RefSeq; NP_859077.1; NM_181726.3.
DR   AlphaFoldDB; Q7Z713; -.
DR   SMR; Q7Z713; -.
DR   BioGRID; 131683; 2.
DR   IntAct; Q7Z713; 2.
DR   STRING; 9606.ENSP00000335147; -.
DR   iPTMnet; Q7Z713; -.
DR   PhosphoSitePlus; Q7Z713; -.
DR   BioMuta; ANKRD37; -.
DR   DMDM; 74750211; -.
DR   PaxDb; Q7Z713; -.
DR   PeptideAtlas; Q7Z713; -.
DR   PRIDE; Q7Z713; -.
DR   Antibodypedia; 52255; 111 antibodies from 20 providers.
DR   DNASU; 353322; -.
DR   Ensembl; ENST00000335174.6; ENSP00000335147.4; ENSG00000186352.9.
DR   GeneID; 353322; -.
DR   KEGG; hsa:353322; -.
DR   MANE-Select; ENST00000335174.6; ENSP00000335147.4; NM_181726.4; NP_859077.1.
DR   UCSC; uc003ixm.4; human.
DR   CTD; 353322; -.
DR   DisGeNET; 353322; -.
DR   GeneCards; ANKRD37; -.
DR   HGNC; HGNC:29593; ANKRD37.
DR   HPA; ENSG00000186352; Tissue enhanced (retina).
DR   MIM; 619021; gene.
DR   neXtProt; NX_Q7Z713; -.
DR   OpenTargets; ENSG00000186352; -.
DR   PharmGKB; PA142672604; -.
DR   VEuPathDB; HostDB:ENSG00000186352; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000154216; -.
DR   HOGENOM; CLU_000134_42_0_1; -.
DR   InParanoid; Q7Z713; -.
DR   OMA; YFLLWQL; -.
DR   PhylomeDB; Q7Z713; -.
DR   TreeFam; TF338463; -.
DR   PathwayCommons; Q7Z713; -.
DR   SignaLink; Q7Z713; -.
DR   BioGRID-ORCS; 353322; 13 hits in 1078 CRISPR screens.
DR   ChiTaRS; ANKRD37; human.
DR   GenomeRNAi; 353322; -.
DR   Pharos; Q7Z713; Tdark.
DR   PRO; PR:Q7Z713; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q7Z713; protein.
DR   Bgee; ENSG00000186352; Expressed in lower esophagus mucosa and 176 other tissues.
DR   ExpressionAtlas; Q7Z713; baseline and differential.
DR   Genevisible; Q7Z713; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF13637; Ank_4; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   1: Evidence at protein level;
KW   ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation.
FT   CHAIN           1..158
FT                   /note="Ankyrin repeat domain-containing protein 37"
FT                   /id="PRO_0000244361"
FT   REPEAT          1..25
FT                   /note="ANK 1"
FT   REPEAT          30..59
FT                   /note="ANK 2"
FT   REPEAT          63..92
FT                   /note="ANK 3"
FT   MOTIF           129..149
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q569N2"
FT   VARIANT         152
FT                   /note="T -> S (in dbSNP:rs4317244)"
FT                   /id="VAR_048279"
SQ   SEQUENCE   158 AA;  16872 MW;  BD5DEB2D8C2E3D67 CRC64;
     MLLLDCNPEV DGLKHLLETG ASVNAPPDPC KQSPVHLAAG SGLACFLLWQ LQTGADLNQQ
     DVLGEAPLHK AAKVGSLECL SLLVASDAQI DLCNKNGQTA EDLAWSCGFP DCAKFLTTIK
     CMQTIKASEH PDRNDCVAVL RQKRSLGSVE NTSGKRKC