ANR37_MOUSE
ID ANR37_MOUSE Reviewed; 159 AA.
AC Q569N2; Q8CHS0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Ankyrin repeat domain-containing protein 37 {ECO:0000305};
GN Name=Ankrd37 {ECO:0000303|PubMed:21723927, ECO:0000312|MGI:MGI:3603344};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND UBIQUITINATION.
RX PubMed=21723927; DOI=10.1016/j.gene.2011.06.025;
RA Shi Y.Q., Liao S.Y., Zhuang X.J., Han C.S.;
RT "Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of
RT Ankrd37.";
RL Gene 485:153-159(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21723927}. Cytoplasm
CC {ECO:0000269|PubMed:21723927}. Note=Present in the cytoplasm of
CC elongating spermatids of the stages IX-X seminiferous tubules while it
CC is localizes to the nucleus of spermatozoa of the stages VII-VIII
CC tubules and mature spermatozoa isolated from epididymis.
CC {ECO:0000269|PubMed:21723927}.
CC -!- TISSUE SPECIFICITY: Expressed testis, ovary, uterus, kidney, liver, but
CC not in other tissues. {ECO:0000269|PubMed:21723927}.
CC -!- PTM: Ubiquitinated by the CRL2(FEM1B) complex, leading to its
CC degradation. {ECO:0000269|PubMed:21723927}.
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DR EMBL; BC039642; AAH39642.2; -; mRNA.
DR EMBL; BC092377; AAH92377.1; -; mRNA.
DR CCDS; CCDS22285.1; -.
DR RefSeq; NP_001034651.1; NM_001039562.1.
DR AlphaFoldDB; Q569N2; -.
DR SMR; Q569N2; -.
DR BioGRID; 576636; 1.
DR STRING; 10090.ENSMUSP00000056828; -.
DR PhosphoSitePlus; Q569N2; -.
DR EPD; Q569N2; -.
DR PaxDb; Q569N2; -.
DR PRIDE; Q569N2; -.
DR Antibodypedia; 52255; 111 antibodies from 20 providers.
DR Ensembl; ENSMUST00000053558; ENSMUSP00000056828; ENSMUSG00000050914.
DR GeneID; 654824; -.
DR KEGG; mmu:654824; -.
DR UCSC; uc009lpr.1; mouse.
DR CTD; 353322; -.
DR MGI; MGI:3603344; Ankrd37.
DR VEuPathDB; HostDB:ENSMUSG00000050914; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000154216; -.
DR HOGENOM; CLU_000134_42_0_1; -.
DR InParanoid; Q569N2; -.
DR OMA; YFLLWQL; -.
DR OrthoDB; 920538at2759; -.
DR PhylomeDB; Q569N2; -.
DR TreeFam; TF338463; -.
DR BioGRID-ORCS; 654824; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ankrd37; mouse.
DR PRO; PR:Q569N2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q569N2; protein.
DR Bgee; ENSMUSG00000050914; Expressed in left lung lobe and 184 other tissues.
DR ExpressionAtlas; Q569N2; baseline and differential.
DR Genevisible; Q569N2; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0001673; C:male germ cell nucleus; IDA:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation.
FT CHAIN 1..159
FT /note="Ankyrin repeat domain-containing protein 37"
FT /id="PRO_0000244362"
FT REPEAT 1..25
FT /note="ANK 1"
FT REPEAT 30..59
FT /note="ANK 2"
FT REPEAT 63..92
FT /note="ANK 3"
FT MOTIF 130..150
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000269|PubMed:21723927"
SQ SEQUENCE 159 AA; 17262 MW; 0E8CAA1D9EDFDB5D CRC64;
MLLLSCNLEE DDLKSLLETG ASVNAPPDPQ EQSPAHLAAG GGLACFLLWQ LQTGADLNQQ
DVLGETPLHK AAKVGSLDCL SLLVASDVQI GVCNKNGQTA EDLAWSYGFP ECARFLTMIK
CMQTARSSGE QQERDPRAPV LRQKRSFRTV ESGVMKRKC
