ANR39_HUMAN
ID ANR39_HUMAN Reviewed; 183 AA.
AC Q53RE8; Q59FU2; Q8N5X5; Q9P0S5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Ankyrin repeat domain-containing protein 39;
GN Name=ANKRD39; ORFNames=HSPC200;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-113.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- SIMILARITY: Belongs to the ANKRD39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF36120.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAD92604.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF151034; AAF36120.1; ALT_FRAME; mRNA.
DR EMBL; AB209367; BAD92604.1; ALT_INIT; mRNA.
DR EMBL; AC092636; AAY14966.1; -; Genomic_DNA.
DR EMBL; BC031303; AAH31303.1; -; mRNA.
DR CCDS; CCDS2028.1; -.
DR RefSeq; NP_057550.3; NM_016466.5.
DR AlphaFoldDB; Q53RE8; -.
DR SMR; Q53RE8; -.
DR BioGRID; 119400; 67.
DR IntAct; Q53RE8; 3.
DR STRING; 9606.ENSP00000377170; -.
DR iPTMnet; Q53RE8; -.
DR PhosphoSitePlus; Q53RE8; -.
DR BioMuta; ANKRD39; -.
DR DMDM; 74740664; -.
DR EPD; Q53RE8; -.
DR jPOST; Q53RE8; -.
DR MassIVE; Q53RE8; -.
DR MaxQB; Q53RE8; -.
DR PaxDb; Q53RE8; -.
DR PeptideAtlas; Q53RE8; -.
DR PRIDE; Q53RE8; -.
DR ProteomicsDB; 62523; -.
DR Antibodypedia; 47508; 75 antibodies from 17 providers.
DR DNASU; 51239; -.
DR Ensembl; ENST00000393537.5; ENSP00000377170.4; ENSG00000213337.9.
DR Ensembl; ENST00000443120.5; ENSP00000398321.1; ENSG00000213337.9.
DR GeneID; 51239; -.
DR KEGG; hsa:51239; -.
DR MANE-Select; ENST00000393537.5; ENSP00000377170.4; NM_016466.6; NP_057550.3.
DR UCSC; uc002sxd.5; human.
DR CTD; 51239; -.
DR DisGeNET; 51239; -.
DR GeneCards; ANKRD39; -.
DR HGNC; HGNC:28640; ANKRD39.
DR HPA; ENSG00000213337; Low tissue specificity.
DR neXtProt; NX_Q53RE8; -.
DR OpenTargets; ENSG00000213337; -.
DR PharmGKB; PA142672606; -.
DR VEuPathDB; HostDB:ENSG00000213337; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160547; -.
DR HOGENOM; CLU_000134_35_1_1; -.
DR InParanoid; Q53RE8; -.
DR OMA; VQKGTDP; -.
DR OrthoDB; 1453481at2759; -.
DR PhylomeDB; Q53RE8; -.
DR TreeFam; TF326597; -.
DR PathwayCommons; Q53RE8; -.
DR SignaLink; Q53RE8; -.
DR BioGRID-ORCS; 51239; 26 hits in 1080 CRISPR screens.
DR ChiTaRS; ANKRD39; human.
DR GenomeRNAi; 51239; -.
DR Pharos; Q53RE8; Tdark.
DR PRO; PR:Q53RE8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q53RE8; protein.
DR Bgee; ENSG00000213337; Expressed in hindlimb stylopod muscle and 139 other tissues.
DR Genevisible; Q53RE8; HS.
DR GO; GO:0070531; C:BRCA1-A complex; IBA:GO_Central.
DR GO; GO:0031436; C:BRCA1-BARD1 complex; IBA:GO_Central.
DR GO; GO:0085020; P:protein K6-linked ubiquitination; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..183
FT /note="Ankyrin repeat domain-containing protein 39"
FT /id="PRO_0000244366"
FT REPEAT 30..59
FT /note="ANK 1"
FT REPEAT 63..92
FT /note="ANK 2"
FT REPEAT 96..125
FT /note="ANK 3"
FT REPEAT 129..158
FT /note="ANK 4"
FT MOD_RES 153
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VARIANT 113
FT /note="A -> T (in dbSNP:rs17852947)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026905"
FT CONFLICT 4
FT /note="P -> L (in Ref. 1; AAF36120)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 183 AA; 19651 MW; 11C13234A456CD63 CRC64;
MATPRPCADG PCCSHPSAVL GVQQTLEEMD FERGIWSAAL NGDLGRVKHL IQKAEDPSQP
DSAGYTALHY ASRNGHYAVC QFLLESGAKC DAQTHGGATA LHRASYCGHT EIARLLLSHG
SNPRVVDDDG MTSLHKAAER GHGDICSLLL QHSPALKAIR DRKARLACDL LPCNSDLRDL
LSS
