ANR40_HUMAN
ID ANR40_HUMAN Reviewed; 368 AA.
AC Q6AI12; Q96E32;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Ankyrin repeat domain-containing protein 40;
GN Name=ANKRD40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 1-13 AND 178-198, ACETYLATION AT MET-1, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Lempens A., Norman J.C.;
RL Submitted (OCT-2009) to UniProtKB.
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q6AI12; P23526: AHCY; NbExp=8; IntAct=EBI-2838246, EBI-1053240;
CC Q6AI12; P51114: FXR1; NbExp=2; IntAct=EBI-2838246, EBI-713291;
CC Q6AI12; Q13526: PIN1; NbExp=6; IntAct=EBI-2838246, EBI-714158;
CC Q6AI12; P54725: RAD23A; NbExp=3; IntAct=EBI-2838246, EBI-746453;
CC Q6AI12; P40938: RFC3; NbExp=3; IntAct=EBI-2838246, EBI-1055010;
CC Q6AI12; O00560: SDCBP; NbExp=3; IntAct=EBI-2838246, EBI-727004;
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DR EMBL; CR627413; CAH10502.1; -; mRNA.
DR EMBL; BC012978; AAH12978.1; -; mRNA.
DR CCDS; CCDS11572.1; -.
DR RefSeq; NP_443087.1; NM_052855.3.
DR AlphaFoldDB; Q6AI12; -.
DR SMR; Q6AI12; -.
DR BioGRID; 124821; 110.
DR IntAct; Q6AI12; 31.
DR MINT; Q6AI12; -.
DR STRING; 9606.ENSP00000285243; -.
DR GlyGen; Q6AI12; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6AI12; -.
DR PhosphoSitePlus; Q6AI12; -.
DR BioMuta; ANKRD40; -.
DR DMDM; 109940224; -.
DR EPD; Q6AI12; -.
DR jPOST; Q6AI12; -.
DR MassIVE; Q6AI12; -.
DR MaxQB; Q6AI12; -.
DR PaxDb; Q6AI12; -.
DR PeptideAtlas; Q6AI12; -.
DR PRIDE; Q6AI12; -.
DR ProteomicsDB; 66185; -.
DR Antibodypedia; 18157; 129 antibodies from 18 providers.
DR DNASU; 91369; -.
DR Ensembl; ENST00000285243.7; ENSP00000285243.6; ENSG00000154945.7.
DR GeneID; 91369; -.
DR KEGG; hsa:91369; -.
DR MANE-Select; ENST00000285243.7; ENSP00000285243.6; NM_052855.4; NP_443087.1.
DR UCSC; uc002iso.4; human.
DR CTD; 91369; -.
DR GeneCards; ANKRD40; -.
DR HGNC; HGNC:28233; ANKRD40.
DR HPA; ENSG00000154945; Tissue enhanced (brain).
DR neXtProt; NX_Q6AI12; -.
DR OpenTargets; ENSG00000154945; -.
DR PharmGKB; PA142672607; -.
DR VEuPathDB; HostDB:ENSG00000154945; -.
DR eggNOG; KOG0307; Eukaryota.
DR GeneTree; ENSGT00390000007792; -.
DR HOGENOM; CLU_068367_0_0_1; -.
DR InParanoid; Q6AI12; -.
DR OMA; CMGPVPA; -.
DR OrthoDB; 1425388at2759; -.
DR PhylomeDB; Q6AI12; -.
DR TreeFam; TF331472; -.
DR PathwayCommons; Q6AI12; -.
DR SignaLink; Q6AI12; -.
DR BioGRID-ORCS; 91369; 18 hits in 1075 CRISPR screens.
DR ChiTaRS; ANKRD40; human.
DR GenomeRNAi; 91369; -.
DR Pharos; Q6AI12; Tdark.
DR PRO; PR:Q6AI12; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6AI12; protein.
DR Bgee; ENSG00000154945; Expressed in medial globus pallidus and 196 other tissues.
DR ExpressionAtlas; Q6AI12; baseline and differential.
DR Genevisible; Q6AI12; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR039195; ANKRD40.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24192; PTHR24192; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW Acetylation; ANK repeat; Direct protein sequencing; Reference proteome;
KW Repeat.
FT CHAIN 1..368
FT /note="Ankyrin repeat domain-containing protein 40"
FT /id="PRO_0000244368"
FT REPEAT 9..38
FT /note="ANK 1"
FT REPEAT 43..72
FT /note="ANK 2"
FT REGION 93..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..172
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|Ref.3, ECO:0007744|PubMed:22223895,
FT ECO:0007744|PubMed:22814378"
FT CONFLICT 352
FT /note="T -> A (in Ref. 1; CAH10502)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 368 AA; 41088 MW; 17999B7FDD3C6A52 CRC64;
MNALLEQKEQ QERLREAAAL GDIREVQKLV ESGVDVNSQN EVNGWTCLHW ACKRNHGQVV
SYLLKSGADK EILTTKGEMP VQLTSRREIR KIMGVEEEDD DDDDDDNLPQ LKKESELPFV
PNYLANPAFP FIYTPTAEDS AQMQNGGPST PPASPPADGS PPLLPPGEPP LLGTFPRDHT
SLALVQNGDV SAPSAILRTP ESTKPGPVCQ PPVSQSRSLF SSVPSKPPMS LEPQNGTYAG
PAPAFQPFFF TGAFPFNMQE LVLKVRIQNP SLRENDFIEI ELDRQELTYQ ELLRVCCCEL
GVNPDQVEKI RKLPNTLLRK DKDVARLQDF QELELVLMIS ENNFLFRNAA STLTERPCYN
RRASKLTY
