ANR40_MOUSE
ID ANR40_MOUSE Reviewed; 363 AA.
AC Q5SUE8; Q5SUF0; Q8R595; Q9CU71;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Ankyrin repeat domain-containing protein 40;
GN Name=Ankrd40;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-363 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5SUE8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SUE8-2; Sequence=VSP_019555, VSP_019556;
CC Name=3;
CC IsoId=Q5SUE8-3; Sequence=VSP_019554, VSP_019557;
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DR EMBL; AL645965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC023133; AAH23133.1; -; mRNA.
DR EMBL; AK017451; BAB30748.1; -; mRNA.
DR CCDS; CCDS25253.2; -. [Q5SUE8-1]
DR CCDS; CCDS36283.1; -. [Q5SUE8-3]
DR RefSeq; NP_082075.2; NM_027799.2. [Q5SUE8-1]
DR RefSeq; NP_666136.1; NM_146024.1. [Q5SUE8-3]
DR AlphaFoldDB; Q5SUE8; -.
DR SMR; Q5SUE8; -.
DR BioGRID; 214717; 1.
DR STRING; 10090.ENSMUSP00000103448; -.
DR iPTMnet; Q5SUE8; -.
DR PhosphoSitePlus; Q5SUE8; -.
DR EPD; Q5SUE8; -.
DR MaxQB; Q5SUE8; -.
DR PaxDb; Q5SUE8; -.
DR PeptideAtlas; Q5SUE8; -.
DR PRIDE; Q5SUE8; -.
DR ProteomicsDB; 281877; -. [Q5SUE8-1]
DR ProteomicsDB; 281878; -. [Q5SUE8-2]
DR ProteomicsDB; 281879; -. [Q5SUE8-3]
DR Antibodypedia; 18157; 129 antibodies from 18 providers.
DR DNASU; 71452; -.
DR Ensembl; ENSMUST00000021227; ENSMUSP00000021227; ENSMUSG00000020864. [Q5SUE8-3]
DR Ensembl; ENSMUST00000051221; ENSMUSP00000061637; ENSMUSG00000020864. [Q5SUE8-2]
DR Ensembl; ENSMUST00000107818; ENSMUSP00000103448; ENSMUSG00000020864. [Q5SUE8-1]
DR GeneID; 71452; -.
DR KEGG; mmu:71452; -.
DR UCSC; uc007kyk.1; mouse. [Q5SUE8-3]
DR UCSC; uc007kyl.1; mouse. [Q5SUE8-1]
DR CTD; 91369; -.
DR MGI; MGI:1918702; Ankrd40.
DR VEuPathDB; HostDB:ENSMUSG00000020864; -.
DR eggNOG; KOG0307; Eukaryota.
DR GeneTree; ENSGT00390000007792; -.
DR HOGENOM; CLU_068367_0_0_1; -.
DR InParanoid; Q5SUE8; -.
DR OMA; CMGPVPA; -.
DR OrthoDB; 1425388at2759; -.
DR PhylomeDB; Q5SUE8; -.
DR TreeFam; TF331472; -.
DR BioGRID-ORCS; 71452; 14 hits in 75 CRISPR screens.
DR ChiTaRS; Ankrd40; mouse.
DR PRO; PR:Q5SUE8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SUE8; protein.
DR Bgee; ENSMUSG00000020864; Expressed in hindlimb stylopod muscle and 262 other tissues.
DR ExpressionAtlas; Q5SUE8; baseline and differential.
DR Genevisible; Q5SUE8; MM.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR039195; ANKRD40.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24192; PTHR24192; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; ANK repeat; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..363
FT /note="Ankyrin repeat domain-containing protein 40"
FT /id="PRO_0000244369"
FT REPEAT 9..38
FT /note="ANK 1"
FT REPEAT 43..72
FT /note="ANK 2"
FT REGION 135..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q6AI12"
FT MOD_RES 176
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 316..324
FT /note="DKDVARLQD -> IKDEPRPWN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019554"
FT VAR_SEQ 316..322
FT /note="DKDVARL -> KRCIHTD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019555"
FT VAR_SEQ 323..363
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019556"
FT VAR_SEQ 325..363
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019557"
FT CONFLICT 7
FT /note="Q -> E (in Ref. 3; BAB30748)"
FT /evidence="ECO:0000305"
FT CONFLICT 11
FT /note="Q -> E (in Ref. 3; BAB30748)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="N -> K (in Ref. 3; BAB30748)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 40560 MW; 7F45DD06268FE157 CRC64;
MSALLEQKEQ QERLREAAAL GDIREVQKLV ESGVDVNSQN EVNGWTCLHW ACKRNHGQVV
SYLLQSGADR EILTTKGEMP VQLTSRREIR KIMGVEEADE EEEIPQLKKE SELPFVPNYL
ANPAFPFIYT PAAEDSTQLQ NGGPSPPPVS PPADSSPPLL PPTETPLLGA FPRDHSSLAL
VQNGDISAPS AILRTPESTK PGPVCQPPVS QNRSLFSVPS KPPVSLEPQN GTYAGPAPAF
QPFFFTGAFP FNMQELVLKV RIQNPSLREN DFIEIELDRQ ELTYQELLRV SCCELGVNPD
QVEKIRKLPN TLLRKDKDVA RLQDFQELEL VLMISDNNFL FRNAASTLTE RPCYNRRASK
LTY
