ANR42_MOUSE
ID ANR42_MOUSE Reviewed; 527 AA.
AC Q3V096; Q8BX55; Q8BZT3; Q8C0T6; Q8C0X5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Ankyrin repeat domain-containing protein 42;
GN Name=Ankrd42;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cecum, Cerebellum, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- INTERACTION:
CC Q3V096; PRO_0000030313 [P25799]: Nfkb1; NbExp=3; IntAct=EBI-15861272, EBI-1209141;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3V096-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3V096-2; Sequence=VSP_019563, VSP_019564;
CC Name=3;
CC IsoId=Q3V096-3; Sequence=VSP_019562, VSP_019565;
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DR EMBL; AK029511; BAC26485.1; -; mRNA.
DR EMBL; AK029888; BAC26659.1; -; mRNA.
DR EMBL; AK033599; BAC28380.1; -; mRNA.
DR EMBL; AK048925; BAC33494.1; -; mRNA.
DR EMBL; AK133339; BAE21608.1; -; mRNA.
DR RefSeq; NP_082941.2; NM_028665.4.
DR AlphaFoldDB; Q3V096; -.
DR SMR; Q3V096; -.
DR DIP; DIP-59545N; -.
DR IntAct; Q3V096; 1.
DR STRING; 10090.ENSMUSP00000113767; -.
DR iPTMnet; Q3V096; -.
DR PhosphoSitePlus; Q3V096; -.
DR MaxQB; Q3V096; -.
DR PaxDb; Q3V096; -.
DR PRIDE; Q3V096; -.
DR ProteomicsDB; 281880; -. [Q3V096-1]
DR ProteomicsDB; 281881; -. [Q3V096-2]
DR ProteomicsDB; 281882; -. [Q3V096-3]
DR Antibodypedia; 17554; 94 antibodies from 19 providers.
DR DNASU; 73845; -.
DR Ensembl; ENSMUST00000056106; ENSMUSP00000061208; ENSMUSG00000041343. [Q3V096-1]
DR Ensembl; ENSMUST00000138267; ENSMUSP00000146446; ENSMUSG00000041343. [Q3V096-3]
DR GeneID; 73845; -.
DR KEGG; mmu:73845; -.
DR UCSC; uc009ihx.2; mouse. [Q3V096-1]
DR UCSC; uc009iia.2; mouse. [Q3V096-2]
DR CTD; 338699; -.
DR MGI; MGI:1921095; Ankrd42.
DR VEuPathDB; HostDB:ENSMUSG00000041343; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000154216; -.
DR InParanoid; Q3V096; -.
DR OrthoDB; 1115202at2759; -.
DR PhylomeDB; Q3V096; -.
DR TreeFam; TF354335; -.
DR BioGRID-ORCS; 73845; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ankrd42; mouse.
DR PRO; PR:Q3V096; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3V096; protein.
DR Bgee; ENSMUSG00000041343; Expressed in spermatid and 115 other tissues.
DR ExpressionAtlas; Q3V096; baseline and differential.
DR Genevisible; Q3V096; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0051059; F:NF-kappaB binding; IPI:MGI.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IMP:MGI.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IMP:MGI.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:MGI.
DR Gene3D; 1.25.40.20; -; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 6.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..527
FT /note="Ankyrin repeat domain-containing protein 42"
FT /id="PRO_0000244372"
FT REPEAT 25..54
FT /note="ANK 1"
FT REPEAT 59..88
FT /note="ANK 2"
FT REPEAT 92..121
FT /note="ANK 3"
FT REPEAT 125..154
FT /note="ANK 4"
FT REPEAT 158..187
FT /note="ANK 5"
FT REPEAT 191..220
FT /note="ANK 6"
FT REPEAT 228..257
FT /note="ANK 7"
FT REPEAT 263..293
FT /note="ANK 8"
FT REPEAT 297..326
FT /note="ANK 9"
FT REPEAT 330..360
FT /note="ANK 10"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 395..484
FT /evidence="ECO:0000255"
FT VAR_SEQ 340..356
FT /note="RFAHLAAVKLLEGLQKY -> SVLSSSCGLGTVATVRR (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019562"
FT VAR_SEQ 341..349
FT /note="FAHLAAVKL -> YKSPSTFFS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019563"
FT VAR_SEQ 350..527
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019564"
FT VAR_SEQ 357..527
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019565"
FT CONFLICT 100
FT /note="A -> P (in Ref. 1; BAC26485)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="A -> P (in Ref. 1; BAC26485)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="G -> S (in Ref. 1; BAC26485)"
FT /evidence="ECO:0000305"
FT CONFLICT 515
FT /note="S -> R (in Ref. 1; BAC26659/BAC26485)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 527 AA; 58533 MW; 5474CB9C33043CDE CRC64;
MPGVANPGPS KSRRETADSS SRKKVHFSSI HDAVRAGDVK QLSDIVERGA NLNEVDALHQ
FTPLHWAAHS GSLECLHWLL WSGADATQTT TRGWTAAHIA AIRGQDACLQ ALIINGANLA
TQDDRGCTPL HLAATHGHSF SLQIMLRSGV DPSVTDKREW KPVHYASFHG RLGCLQLLVK
WGCGIEDVDY NGNLPVHLAA MEGHLHCLKF LLSRMNSATQ ALKAFNDNGE NVLDLAQRFL
KQNVVEFIQG AQYEGSHPDD HDDLAFPGHV AAFKGDLEVL KKLIGDGVIN LNERDDNGST
PMHKAAGQGH IDCLQWLIEM GAESNITNKA GETPSDVAKR FAHLAAVKLL EGLQKYEIDD
IESDKDHINF FTRHGVEGST DAKDDLCLSE SDKANARMRA HKKIVELRQL LEIAESNFKH
LGGITEEDLK QKKEQLESKK TINELQGQLA YERLRREKLE CQLDEYRVEV DQLKETLQKI
QVTSVAAMED DSCESSKEKR RVKKKVSPGG VFVRSYQRIR TSISSQV
