ID   HIS7_CANGA              Reviewed;         210 AA.
AC   Q12578; Q6FLJ5; Q8TFK9;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=HIS3; OrderedLocusNames=CAGL0L02937g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=8522176; DOI=10.1016/0378-1119(95)00552-h;
RA   Kitada K., Yamaguchi E., Arisawa M.;
RT   "Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of
RT   their disruptant strains by sequential integrative transformation.";
RL   Gene 165:203-206(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=12125055; DOI=10.1002/yea.890;
RA   Walsh D.W., Wolfe K.H., Butler G.;
RT   "Genomic differences between Candida glabrata and Saccharomyces cerevisiae
RT   around the MRPL28 and GCN3 loci.";
RL   Yeast 19:991-994(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; U31470; AAC49145.1; -; Genomic_DNA.
DR   EMBL; AY083607; AAM08101.1; -; Genomic_DNA.
DR   EMBL; CR380958; CAG61869.1; -; Genomic_DNA.
DR   PIR; JC4381; JC4381.
DR   RefSeq; XP_448899.1; XM_448899.1.
DR   AlphaFoldDB; Q12578; -.
DR   SMR; Q12578; -.
DR   STRING; 5478.XP_448899.1; -.
DR   EnsemblFungi; CAG61869; CAG61869; CAGL0L02937g.
DR   GeneID; 2890838; -.
DR   KEGG; cgr:CAGL0L02937g; -.
DR   CGD; CAL0135520; HIS3.
DR   VEuPathDB; FungiDB:CAGL0L02937g; -.
DR   eggNOG; KOG3143; Eukaryota.
DR   HOGENOM; CLU_044308_3_0_1; -.
DR   InParanoid; Q12578; -.
DR   OMA; ARHGLFD; -.
DR   UniPathway; UPA00031; UER00011.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IMP:CGD.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158235"
FT   CONFLICT        161
FT                   /note="A -> G (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        182
FT                   /note="A -> G (in Ref. 1; AAC49145)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  22819 MW;  7959F697253CBC31 CRC64;
     MAFVKRVTQE TNIQLALDLD GGSVSVRESI LGKEYASGDG QTIHVHTGVG FLDHMLTALA
     KHGGWSLILE CIGDLHIDDH HTVEDCGIAL GQAFKEALGS VRGIKRFGHG FAPLDEALSR
     AVVDFSNRPF AVVELGLKRE RIGQLSTEMI PHFLESFATE ARITMHVDCL RGTNDHHRSE
     SAFKALAIAI REARTPTGRD DVPSTKGVLA