ANR44_MOUSE
ID ANR44_MOUSE Reviewed; 993 AA.
AC B2RXR6; B2RXN6; B7ZWK8;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B;
DE Short=PP6-ARS-B;
DE Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B;
DE AltName: Full=Ankyrin repeat domain-containing protein 44;
GN Name=Ankrd44;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6)
CC that may be involved in the recognition of phosphoprotein substrates.
CC {ECO:0000250}.
CC -!- SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a
CC heterotrimeric complex formed by the catalytic subunit, a SAPS domain-
CC containing subunit (PP6R) and an ankyrin repeat-domain containing
CC regulatory subunit (ARS). Interacts with PPP6R1 (By similarity).
CC {ECO:0000250}.
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DR EMBL; BC157918; AAI57919.1; -; mRNA.
DR EMBL; BC157951; AAI57952.1; -; mRNA.
DR EMBL; BC172102; AAI72102.1; -; mRNA.
DR CCDS; CCDS35566.2; -.
DR RefSeq; NP_001074902.2; NM_001081433.3.
DR AlphaFoldDB; B2RXR6; -.
DR SMR; B2RXR6; -.
DR BioGRID; 236716; 2.
DR IntAct; B2RXR6; 8.
DR MINT; B2RXR6; -.
DR STRING; 10090.ENSMUSP00000040327; -.
DR iPTMnet; B2RXR6; -.
DR PhosphoSitePlus; B2RXR6; -.
DR EPD; B2RXR6; -.
DR MaxQB; B2RXR6; -.
DR PaxDb; B2RXR6; -.
DR PeptideAtlas; B2RXR6; -.
DR PRIDE; B2RXR6; -.
DR ProteomicsDB; 282120; -.
DR Antibodypedia; 34063; 93 antibodies from 18 providers.
DR Ensembl; ENSMUST00000179030; ENSMUSP00000137616; ENSMUSG00000052331.
DR GeneID; 329154; -.
DR KEGG; mmu:329154; -.
DR UCSC; uc011wkz.1; mouse.
DR CTD; 91526; -.
DR MGI; MGI:3045243; Ankrd44.
DR VEuPathDB; HostDB:ENSMUSG00000052331; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00950000182908; -.
DR InParanoid; B2RXR6; -.
DR OMA; KCFRKFV; -.
DR OrthoDB; 1115202at2759; -.
DR PhylomeDB; B2RXR6; -.
DR BioGRID-ORCS; 329154; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ankrd44; mouse.
DR PRO; PR:B2RXR6; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; B2RXR6; protein.
DR Bgee; ENSMUSG00000052331; Expressed in animal zygote and 234 other tissues.
DR ExpressionAtlas; B2RXR6; baseline and differential.
DR Genevisible; B2RXR6; MM.
DR Gene3D; 1.25.40.20; -; 9.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 10.
DR Pfam; PF13637; Ank_4; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 28.
DR SUPFAM; SSF48403; SSF48403; 4.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 23.
PE 1: Evidence at protein level;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..993
FT /note="Serine/threonine-protein phosphatase 6 regulatory
FT ankyrin repeat subunit B"
FT /id="PRO_0000355975"
FT REPEAT 7..36
FT /note="ANK 1"
FT REPEAT 40..69
FT /note="ANK 2"
FT REPEAT 73..102
FT /note="ANK 3"
FT REPEAT 106..135
FT /note="ANK 4"
FT REPEAT 139..168
FT /note="ANK 5"
FT REPEAT 172..201
FT /note="ANK 6"
FT REPEAT 205..234
FT /note="ANK 7"
FT REPEAT 238..267
FT /note="ANK 8"
FT REPEAT 271..301
FT /note="ANK 9"
FT REPEAT 305..334
FT /note="ANK 10"
FT REPEAT 338..367
FT /note="ANK 11"
FT REPEAT 371..400
FT /note="ANK 12"
FT REPEAT 404..433
FT /note="ANK 13"
FT REPEAT 437..466
FT /note="ANK 14"
FT REPEAT 470..498
FT /note="ANK 15"
FT REPEAT 531..561
FT /note="ANK 16"
FT REPEAT 566..595
FT /note="ANK 17"
FT REPEAT 599..628
FT /note="ANK 18"
FT REPEAT 633..662
FT /note="ANK 19"
FT REPEAT 669..698
FT /note="ANK 20"
FT REPEAT 702..731
FT /note="ANK 21"
FT REPEAT 735..764
FT /note="ANK 22"
FT REPEAT 771..800
FT /note="ANK 23"
FT REPEAT 803..832
FT /note="ANK 24"
FT REPEAT 838..867
FT /note="ANK 25"
FT REPEAT 871..901
FT /note="ANK 26"
FT REPEAT 905..934
FT /note="ANK 27"
FT REPEAT 941..970
FT /note="ANK 28"
FT REGION 974..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 63
FT /note="S -> L (in Ref. 1; AAI57919)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 993 AA; 107385 MW; 56BDAE434659C072 CRC64;
MAVLKLCEQP PLVQAIFSGD PEEIRMLIHK TEDVNALDSE KRTPLHVAAF LGDAEIIELL
ILSGARVNAK DNMWLTPLHR AVASRSEEAV QVLIKHSADV NARDKNWQTP LHVAAANKAV
KCAEVIIPLL SSVNVSDRGG RTALHHAALN GHMEMVNLLL AKGANINAFD KKDRRALHWA
AYMGHLDVVA LLINHGAEVT CKDKKGYTPL HAAASNGQIS VVKHLLNLGV EIDEINVYGN
TALHIACYNG QDAVVNELID YGANVNQPNN SGFTPLHFAA ASTHGALCLE LLVNNGADVN
IQSKDGKSPL HMTAVHGRFT RSQTLIQNGG EIDCVDKDGN TPLHVAARHG HELLINTLIT
SGADTAKCGI HSMFPLHLAA LNAHSDCCRK LLSSGFEIDT PDTFGRTCLH AAAAGGNVEC
IKLLQSSGAD FHKKDKCGRT PLHYAAANCH FHCIKALVTT GANVNETDDW GRTALHYAAA
SDMDRNKMIL GNAHDNSEEL ERAREVKEKD AALCLEFLLQ NDANPSIRDK EGYNSIHYAA
AYGHRQCLEL LLERTNTGFE ESDGGALKSP LHLAAYNGHH QALEVLLQSL VDLDIRDEKG
RTALYLAAFK GHTECVEALV NQGASIFVKD NVTKRTPLHA SVINGHTLCL RLLLETADNP
EVVDVKDAKG QTPLMLAVAY GHIDAVSLLL EKEANVDAVD IVGCTALHRG IMTGHEECVQ
MLLEQEASIL CKDSRGRTPL HYAAARGHAT WLNELLQIAL SEEDCCLKDN QGYTPLHWAC
YNGNENCIEV LLEQKCFRKF IGNPFTPLHC AIINGHESCA SLLLGAIDPS IVSCRDDKGR
TTLHAAAFGD HAECLQLLLR HDAQVNAVDN SGKTALMMAA ENGQAGAVDI LVNSAQADLT
VKDKDLNTPL HLAISKGHEK CALLILDKIQ DESLINAKNS ALQTPLHIAA RNGLKVVVEE
LLAKGACVLA VDENASRSNG PRSPPGTAVR KEE
