ANR45_HUMAN
ID ANR45_HUMAN Reviewed; 266 AA.
AC Q5TZF3; A1A4G2; Q6ZST1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Ankyrin repeat domain-containing protein 45 {ECO:0000305};
GN Name=ANKRD45 {ECO:0000312|HGNC:HGNC:24786};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=31208154; DOI=10.3390/genes10060462;
RA Kang Y., Xie H., Zhao C.;
RT "Ankrd45 Is a Novel Ankyrin Repeat Protein Required for Cell
RT Proliferation.";
RL Genes (Basel) 10:0-0(2019).
CC -!- FUNCTION: May play a role during cell division.
CC {ECO:0000269|PubMed:31208154}.
CC -!- INTERACTION:
CC Q5TZF3; Q96E03: MAGEA2B; NbExp=3; IntAct=EBI-10247255, EBI-10239285;
CC Q5TZF3-1; P42858: HTT; NbExp=3; IntAct=EBI-22011535, EBI-466029;
CC Q5TZF3-1; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-22011535, EBI-12039345;
CC Q5TZF3-1; P43356: MAGEA2B; NbExp=3; IntAct=EBI-22011535, EBI-5650739;
CC Q5TZF3-1; Q96CV9: OPTN; NbExp=3; IntAct=EBI-22011535, EBI-748974;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31208154}. Midbody,
CC Midbody ring {ECO:0000269|PubMed:31208154}. Cleavage furrow
CC {ECO:0000269|PubMed:31208154}. Note=Distribution is highly dynamic
CC during mitosis. Not detected during interphase, localized to cytoplasm
CC during metaphase, to cleavage furrow during anaphase and telophase, and
CC to midbody ring during cytokinesis. {ECO:0000269|PubMed:31208154}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5TZF3-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5TZF3-1; Sequence=VSP_059723;
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DR EMBL; AK127170; BAC86865.1; -; mRNA.
DR EMBL; AL139142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW90950.1; -; Genomic_DNA.
DR EMBL; BC126353; AAI26354.1; -; mRNA.
DR EMBL; BC126355; AAI26356.1; -; mRNA.
DR CCDS; CCDS1309.1; -. [Q5TZF3-2]
DR RefSeq; NP_940895.1; NM_198493.2. [Q5TZF3-2]
DR RefSeq; XP_011507768.1; XM_011509466.2. [Q5TZF3-2]
DR RefSeq; XP_011507769.1; XM_011509467.1.
DR RefSeq; XP_011507770.1; XM_011509468.1.
DR RefSeq; XP_011507772.1; XM_011509470.1. [Q5TZF3-2]
DR AlphaFoldDB; Q5TZF3; -.
DR SMR; Q5TZF3; -.
DR BioGRID; 130881; 6.
DR IntAct; Q5TZF3; 7.
DR STRING; 9606.ENSP00000331268; -.
DR iPTMnet; Q5TZF3; -.
DR PhosphoSitePlus; Q5TZF3; -.
DR BioMuta; ANKRD45; -.
DR DMDM; 74756674; -.
DR EPD; Q5TZF3; -.
DR MassIVE; Q5TZF3; -.
DR MaxQB; Q5TZF3; -.
DR PaxDb; Q5TZF3; -.
DR PeptideAtlas; Q5TZF3; -.
DR PRIDE; Q5TZF3; -.
DR ProteomicsDB; 65217; -. [Q5TZF3-1]
DR ProteomicsDB; 65218; -. [Q5TZF3-2]
DR Antibodypedia; 34395; 87 antibodies from 17 providers.
DR DNASU; 339416; -.
DR Ensembl; ENST00000333279.3; ENSP00000331268.2; ENSG00000183831.7. [Q5TZF3-2]
DR GeneID; 339416; -.
DR KEGG; hsa:339416; -.
DR MANE-Select; ENST00000333279.3; ENSP00000331268.2; NM_198493.3; NP_940895.1.
DR UCSC; uc001gja.2; human. [Q5TZF3-2]
DR CTD; 339416; -.
DR DisGeNET; 339416; -.
DR GeneCards; ANKRD45; -.
DR HGNC; HGNC:24786; ANKRD45.
DR HPA; ENSG00000183831; Group enriched (brain, choroid plexus, fallopian tube, parathyroid gland, testis).
DR MIM; 618712; gene.
DR neXtProt; NX_Q5TZF3; -.
DR OpenTargets; ENSG00000183831; -.
DR PharmGKB; PA142672612; -.
DR VEuPathDB; HostDB:ENSG00000183831; -.
DR eggNOG; KOG0100; Eukaryota.
DR GeneTree; ENSGT00390000008829; -.
DR HOGENOM; CLU_087014_0_0_1; -.
DR InParanoid; Q5TZF3; -.
DR OMA; CRVKSDW; -.
DR OrthoDB; 1354745at2759; -.
DR PhylomeDB; Q5TZF3; -.
DR TreeFam; TF329503; -.
DR PathwayCommons; Q5TZF3; -.
DR SignaLink; Q5TZF3; -.
DR BioGRID-ORCS; 339416; 7 hits in 1069 CRISPR screens.
DR ChiTaRS; ANKRD45; human.
DR GenomeRNAi; 339416; -.
DR Pharos; Q5TZF3; Tdark.
DR PRO; PR:Q5TZF3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TZF3; protein.
DR Bgee; ENSG00000183831; Expressed in sperm and 88 other tissues.
DR Genevisible; Q5TZF3; HS.
DR GO; GO:0032154; C:cleavage furrow; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0090543; C:Flemming body; IEA:UniProtKB-SubCell.
DR GO; GO:0030496; C:midbody; IDA:UniProtKB.
DR GO; GO:0008283; P:cell population proliferation; IMP:UniProtKB.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR029048; HSP70_C_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF100934; SSF100934; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..266
FT /note="Ankyrin repeat domain-containing protein 45"
FT /id="PRO_0000244574"
FT REPEAT 76..105
FT /note="ANK 1"
FT REPEAT 109..138
FT /note="ANK 2"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..30
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MVTEEAGARVWVFLELM (in isoform 2)"
FT /id="VSP_059723"
SQ SEQUENCE 266 AA; 29977 MW; B0ABDCB676455060 CRC64;
MESEGPPESE SSEFFSQQEE ENEEEEAQEP EETGPKNPLL QPALTGDVEG LQKIFEDPEN
PHHEQAMQLL LEEDIVGRNL LYAACMAGQS DVIRALAKYG VNLNEKTTRG YTLLHCAAAW
GRLETLKALV ELDVDIEALN FREERARDVA ARYSQTECVE FLDWADARLT LKKYIAKVSL
AVTDTEKGSG KLLKEDKNTI LSACRAKNEW LETHTEASIN ELFEQRQQLE DIVTPIFTKM
TTPCQVKSAK SVTSHDQKRS QDDTSN
