ID   ANR45_MOUSE             Reviewed;         248 AA.
AC   Q810N6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Ankyrin repeat domain-containing protein 45;
GN   Name=Ankrd45;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May play a role during cell division.
CC       {ECO:0000250|UniProtKB:Q5TZF3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5TZF3}.
CC       Midbody, Midbody ring {ECO:0000250|UniProtKB:Q5TZF3}. Cleavage furrow
CC       {ECO:0000250|UniProtKB:Q5TZF3}. Note=Distribution is highly dynamic
CC       during mitosis. Not detected during interphase, localized to cytoplasm
CC       during metaphase, to cleavage furrow during anaphase and telophase, and
CC       to midbody ring during cytokinesis. {ECO:0000250|UniProtKB:Q5TZF3}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC049713; AAH49713.1; -; mRNA.
DR   CCDS; CCDS87902.1; -.
DR   RefSeq; NP_082940.1; NM_028664.1.
DR   RefSeq; XP_017167975.1; XM_017312486.1.
DR   AlphaFoldDB; Q810N6; -.
DR   SMR; Q810N6; -.
DR   STRING; 10090.ENSMUSP00000059923; -.
DR   iPTMnet; Q810N6; -.
DR   PhosphoSitePlus; Q810N6; -.
DR   PaxDb; Q810N6; -.
DR   PRIDE; Q810N6; -.
DR   ProteomicsDB; 296257; -.
DR   Ensembl; ENSMUST00000111608; ENSMUSP00000107235; ENSMUSG00000044835.
DR   GeneID; 73844; -.
DR   KEGG; mmu:73844; -.
DR   CTD; 339416; -.
DR   MGI; MGI:1921094; Ankrd45.
DR   VEuPathDB; HostDB:ENSMUSG00000044835; -.
DR   eggNOG; KOG0100; Eukaryota.
DR   GeneTree; ENSGT00390000008829; -.
DR   InParanoid; Q810N6; -.
DR   OMA; CRVKSDW; -.
DR   OrthoDB; 1354745at2759; -.
DR   PhylomeDB; Q810N6; -.
DR   BioGRID-ORCS; 73844; 0 hits in 72 CRISPR screens.
DR   PRO; PR:Q810N6; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q810N6; protein.
DR   Bgee; ENSMUSG00000044835; Expressed in superior cervical ganglion and 72 other tissues.
DR   ExpressionAtlas; Q810N6; baseline and differential.
DR   Genevisible; Q810N6; MM.
DR   GO; GO:0032154; C:cleavage furrow; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0090543; C:Flemming body; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR   GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   1: Evidence at protein level;
KW   ANK repeat; Cytoplasm; Reference proteome; Repeat.
FT   CHAIN           1..248
FT                   /note="Ankyrin repeat domain-containing protein 45"
FT                   /id="PRO_0000244575"
FT   REPEAT          75..104
FT                   /note="ANK 1"
FT   REPEAT          108..137
FT                   /note="ANK 2"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   248 AA;  27734 MW;  65CD6026F4EFA5D0 CRC64;
     MEPEETLESE SSEKSLFSSQ QEYEESQEAE ETGAENPLLQ PTLTGDVEGL QKIFEDPEHP
     HHEHAVQLLL EEDIVGRNLL YAACMAGKSD VIKALAKYGV NLNEATARGY TLLHCAAAWG
     RLETLKALVE LDVDIEALNF RGEKARDVAA RYSQVECVNF LDWADARLIL KKIITKSSLI
     ITDPEKGPGK LFKEDKSTIL NACRLKNEWL ESHPEASISE IFEQKQQLED IVSPILAKMS
     TPRHFAAS