ID   3SOB4_DENJA             Reviewed;          60 AA.
AC   P01406;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Toxin S5C4;
OS   Dendroaspis jamesoni kaimosae (Eastern Jameson's mamba).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8619;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=669583;
RA   Joubert F.J., Strydom A.J.C., Taljaard N.;
RT   "Snake venoms. The amino-acid sequence of protein S5C4 from Dendroaspis
RT   jamesoni kaimosae (Jameson's mamba) venom.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 359:741-749(1978).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:669583}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is >250 mg/kg by intravenous injection.
CC       {ECO:0000269|PubMed:669583}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XI sub-subfamily. {ECO:0000305}.
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DR   PIR; A01677; T5EP2J.
DR   AlphaFoldDB; P01406; -.
DR   SMR; P01406; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..60
FT                   /note="Toxin S5C4"
FT                   /evidence="ECO:0000269|PubMed:669583"
FT                   /id="PRO_0000093660"
FT   DISULFID        3..22
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        17..39
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        41..52
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        53..58
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
SQ   SEQUENCE   60 AA;  6772 MW;  D8093236EFA69364 CRC64;
     MICYSHKTPQ NSATITCEEK TCYKKFVTNV PGVILARGCG CPKKEIFRSI HCCRSDKCNE