ID   ANR46_BOVIN             Reviewed;         228 AA.
AC   Q3SX00;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Ankyrin repeat domain-containing protein 46;
GN   Name=ANKRD46;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC104580; AAI04581.1; -; mRNA.
DR   RefSeq; NP_001029791.1; NM_001034619.1.
DR   AlphaFoldDB; Q3SX00; -.
DR   SMR; Q3SX00; -.
DR   STRING; 9913.ENSBTAP00000001658; -.
DR   PaxDb; Q3SX00; -.
DR   PRIDE; Q3SX00; -.
DR   Ensembl; ENSBTAT00000001658; ENSBTAP00000001658; ENSBTAG00000001254.
DR   GeneID; 534898; -.
DR   KEGG; bta:534898; -.
DR   CTD; 157567; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001254; -.
DR   VGNC; VGNC:25932; ANKRD46.
DR   eggNOG; KOG0508; Eukaryota.
DR   GeneTree; ENSGT00940000157094; -.
DR   HOGENOM; CLU_084801_0_0_1; -.
DR   InParanoid; Q3SX00; -.
DR   OMA; ATEYQGN; -.
DR   OrthoDB; 1170443at2759; -.
DR   TreeFam; TF330790; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000001254; Expressed in occipital lobe and 106 other tissues.
DR   ExpressionAtlas; Q3SX00; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..228
FT                   /note="Ankyrin repeat domain-containing protein 46"
FT                   /id="PRO_0000244576"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..40
FT                   /note="ANK 1"
FT   REPEAT          44..73
FT                   /note="ANK 2"
FT   REPEAT          77..103
FT                   /note="ANK 3"
FT   REPEAT          107..138
FT                   /note="ANK 4"
SQ   SEQUENCE   228 AA;  25330 MW;  F49A43CE49A28A0C CRC64;
     MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI
     CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV
     NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR
     TTWQEFVEDL GFWRVLLLIF VIALLSLGIA YYVSGVLPFV ENQPELVH