ID   ANR46_DANRE             Reviewed;         228 AA.
AC   Q6TNT2; Q504K9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Ankyrin repeat domain-containing protein 46;
GN   Name=ankrd46; ORFNames=zgc:109722;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AY391435; AAQ91247.1; -; mRNA.
DR   EMBL; BC094966; AAH94966.1; -; mRNA.
DR   RefSeq; NP_991159.1; NM_205596.1.
DR   RefSeq; XP_005166560.1; XM_005166503.2.
DR   AlphaFoldDB; Q6TNT2; -.
DR   SMR; Q6TNT2; -.
DR   STRING; 7955.ENSDARP00000020125; -.
DR   PaxDb; Q6TNT2; -.
DR   Ensembl; ENSDART00000022918; ENSDARP00000020125; ENSDARG00000015780.
DR   Ensembl; ENSDART00000160398; ENSDARP00000133092; ENSDARG00000015780.
DR   GeneID; 402888; -.
DR   KEGG; dre:402888; -.
DR   CTD; 402888; -.
DR   ZFIN; ZDB-GENE-050114-7; ankrd46b.
DR   eggNOG; KOG0508; Eukaryota.
DR   GeneTree; ENSGT00940000157094; -.
DR   HOGENOM; CLU_084801_0_0_1; -.
DR   InParanoid; Q6TNT2; -.
DR   OMA; ATEYQGN; -.
DR   OrthoDB; 1170443at2759; -.
DR   PhylomeDB; Q6TNT2; -.
DR   TreeFam; TF330790; -.
DR   PRO; PR:Q6TNT2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000015780; Expressed in brain and 27 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..228
FT                   /note="Ankyrin repeat domain-containing protein 46"
FT                   /id="PRO_0000244581"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..40
FT                   /note="ANK 1"
FT   REPEAT          44..73
FT                   /note="ANK 2"
FT   REPEAT          77..103
FT                   /note="ANK 3"
FT   REPEAT          107..138
FT                   /note="ANK 4"
FT   CONFLICT        160
FT                   /note="E -> G (in Ref. 2; AAH94966)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   228 AA;  25121 MW;  734EA2FB1F0E0562 CRC64;
     MSYVFINDSS QTSVPLLQAC IDGDLSFARR LLETGCDPNI RDHRGRTGLH LAAARGNVDI
     CRFLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHNGST PLVLAKRRGV
     NKDAIRLLEG LEEQEVKGFN RGAHSKLEAM QMAESESAME SHSLLNPNLQ NSEGVLSSFR
     STWQEFVEDL GFWRVLLLLV VIALLSLGIA YYVSGVLPFS ASQLELVH