ANR46_HUMAN
ID ANR46_HUMAN Reviewed; 228 AA.
AC Q86W74; Q6P9B7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-AUG-2020, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Ankyrin repeat domain-containing protein 46;
DE AltName: Full=Ankyrin repeat small protein;
DE Short=ANK-S;
GN Name=ANKRD46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Yamamura N., Koike N., Nomura Y., Sakaki Y., Tashiro T., Furihata C.;
RT "A novel ankyrin-repeat containing gene expressed in SAMP8 hippocampus.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- INTERACTION:
CC Q86W74-2; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-12109402, EBI-19125216;
CC Q86W74-2; Q96BI3: APH1A; NbExp=3; IntAct=EBI-12109402, EBI-2606935;
CC Q86W74-2; Q13520: AQP6; NbExp=3; IntAct=EBI-12109402, EBI-13059134;
CC Q86W74-2; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12109402, EBI-11343438;
CC Q86W74-2; Q13323: BIK; NbExp=3; IntAct=EBI-12109402, EBI-700794;
CC Q86W74-2; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-12109402, EBI-11532900;
CC Q86W74-2; Q6UWD8: C16orf54; NbExp=3; IntAct=EBI-12109402, EBI-18041102;
CC Q86W74-2; P20273-5: CD22; NbExp=3; IntAct=EBI-12109402, EBI-13320645;
CC Q86W74-2; P15529-3: CD46; NbExp=3; IntAct=EBI-12109402, EBI-13046140;
CC Q86W74-2; P56880: CLDN20; NbExp=3; IntAct=EBI-12109402, EBI-23801559;
CC Q86W74-2; O95471: CLDN7; NbExp=3; IntAct=EBI-12109402, EBI-740744;
CC Q86W74-2; Q8WXI8: CLEC4D; NbExp=3; IntAct=EBI-12109402, EBI-12703404;
CC Q86W74-2; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-12109402, EBI-17233035;
CC Q86W74-2; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12109402, EBI-6942903;
CC Q86W74-2; P78310: CXADR; NbExp=3; IntAct=EBI-12109402, EBI-747931;
CC Q86W74-2; P49447: CYB561; NbExp=3; IntAct=EBI-12109402, EBI-8646596;
CC Q86W74-2; Q15125: EBP; NbExp=3; IntAct=EBI-12109402, EBI-3915253;
CC Q86W74-2; P98172: EFNB1; NbExp=3; IntAct=EBI-12109402, EBI-538287;
CC Q86W74-2; P52799: EFNB2; NbExp=3; IntAct=EBI-12109402, EBI-7532268;
CC Q86W74-2; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-12109402, EBI-18535450;
CC Q86W74-2; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-12109402, EBI-18636064;
CC Q86W74-2; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12109402, EBI-18304435;
CC Q86W74-2; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-12109402, EBI-712073;
CC Q86W74-2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12109402, EBI-13345167;
CC Q86W74-2; O15529: GPR42; NbExp=3; IntAct=EBI-12109402, EBI-18076404;
CC Q86W74-2; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-12109402, EBI-1052304;
CC Q86W74-2; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12109402, EBI-18053395;
CC Q86W74-2; Q8IU57: IFNLR1; NbExp=3; IntAct=EBI-12109402, EBI-373215;
CC Q86W74-2; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-12109402, EBI-749265;
CC Q86W74-2; P43628: KIR2DL3; NbExp=3; IntAct=EBI-12109402, EBI-8632435;
CC Q86W74-2; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-12109402, EBI-10173166;
CC Q86W74-2; Q8N386: LRRC25; NbExp=3; IntAct=EBI-12109402, EBI-11304917;
CC Q86W74-2; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12109402, EBI-11956541;
CC Q86W74-2; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-12109402, EBI-6163737;
CC Q86W74-2; P15941-11: MUC1; NbExp=3; IntAct=EBI-12109402, EBI-17263240;
CC Q86W74-2; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-12109402, EBI-10247000;
CC Q86W74-2; Q9Y328: NSG2; NbExp=3; IntAct=EBI-12109402, EBI-7101695;
CC Q86W74-2; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-12109402, EBI-10485931;
CC Q86W74-2; P15151: PVR; NbExp=3; IntAct=EBI-12109402, EBI-3919694;
CC Q86W74-2; Q8NC24: RELL2; NbExp=3; IntAct=EBI-12109402, EBI-10269209;
CC Q86W74-2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-12109402, EBI-10192441;
CC Q86W74-2; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12109402, EBI-17247926;
CC Q86W74-2; Q8WVN6: SECTM1; NbExp=3; IntAct=EBI-12109402, EBI-2855289;
CC Q86W74-2; A0PJX4: SHISA3; NbExp=3; IntAct=EBI-12109402, EBI-10171518;
CC Q86W74-2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-12109402, EBI-18159983;
CC Q86W74-2; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-12109402, EBI-17595455;
CC Q86W74-2; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-12109402, EBI-2823239;
CC Q86W74-2; Q969X2: ST6GALNAC6; NbExp=3; IntAct=EBI-12109402, EBI-949146;
CC Q86W74-2; Q16623: STX1A; NbExp=3; IntAct=EBI-12109402, EBI-712466;
CC Q86W74-2; P32856-2: STX2; NbExp=3; IntAct=EBI-12109402, EBI-11956649;
CC Q86W74-2; Q12846: STX4; NbExp=3; IntAct=EBI-12109402, EBI-744942;
CC Q86W74-2; Q96L08: SUSD3; NbExp=3; IntAct=EBI-12109402, EBI-18194029;
CC Q86W74-2; Q8WY91: THAP4; NbExp=3; IntAct=EBI-12109402, EBI-726691;
CC Q86W74-2; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-12109402, EBI-6268651;
CC Q86W74-2; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-12109402, EBI-10314986;
CC Q86W74-2; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-12109402, EBI-3923061;
CC Q86W74-2; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-12109402, EBI-8649725;
CC Q86W74-2; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-12109402, EBI-12345267;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86W74-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86W74-1; Sequence=VSP_060673;
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DR EMBL; AB077205; BAD23947.1; -; mRNA.
DR EMBL; AL832842; CAI46169.1; -; mRNA.
DR EMBL; BC050396; AAH50396.1; -; mRNA.
DR EMBL; BC060843; AAH60843.1; -; mRNA.
DR CCDS; CCDS59109.1; -. [Q86W74-1]
DR CCDS; CCDS6287.1; -. [Q86W74-2]
DR RefSeq; NP_001257306.1; NM_001270377.1. [Q86W74-2]
DR RefSeq; NP_001257307.1; NM_001270378.1. [Q86W74-2]
DR RefSeq; NP_001257308.1; NM_001270379.1. [Q86W74-1]
DR RefSeq; NP_940683.1; NM_198401.3. [Q86W74-2]
DR RefSeq; XP_006716572.1; XM_006716509.1.
DR RefSeq; XP_016868595.1; XM_017013106.1.
DR AlphaFoldDB; Q86W74; -.
DR SMR; Q86W74; -.
DR BioGRID; 127604; 120.
DR IntAct; Q86W74; 79.
DR STRING; 9606.ENSP00000429015; -.
DR iPTMnet; Q86W74; -.
DR PhosphoSitePlus; Q86W74; -.
DR BioMuta; ANKRD46; -.
DR DMDM; 74750488; -.
DR EPD; Q86W74; -.
DR jPOST; Q86W74; -.
DR MassIVE; Q86W74; -.
DR MaxQB; Q86W74; -.
DR PaxDb; Q86W74; -.
DR PeptideAtlas; Q86W74; -.
DR PRIDE; Q86W74; -.
DR ProteomicsDB; 70129; -. [Q86W74-1]
DR ProteomicsDB; 70130; -. [Q86W74-2]
DR Antibodypedia; 51983; 70 antibodies from 15 providers.
DR DNASU; 157567; -.
DR Ensembl; ENST00000335659.7; ENSP00000335287.3; ENSG00000186106.11. [Q86W74-2]
DR Ensembl; ENST00000519597.5; ENSP00000430056.1; ENSG00000186106.11. [Q86W74-2]
DR Ensembl; ENST00000520311.5; ENSP00000428388.1; ENSG00000186106.11. [Q86W74-2]
DR Ensembl; ENST00000520552.5; ENSP00000429015.1; ENSG00000186106.11. [Q86W74-1]
DR GeneID; 157567; -.
DR KEGG; hsa:157567; -.
DR MANE-Select; ENST00000335659.7; ENSP00000335287.3; NM_001270377.2; NP_001257306.1.
DR UCSC; uc003yjm.5; human. [Q86W74-2]
DR CTD; 157567; -.
DR DisGeNET; 157567; -.
DR GeneCards; ANKRD46; -.
DR HGNC; HGNC:27229; ANKRD46.
DR HPA; ENSG00000186106; Low tissue specificity.
DR neXtProt; NX_Q86W74; -.
DR OpenTargets; ENSG00000186106; -.
DR PharmGKB; PA142672613; -.
DR VEuPathDB; HostDB:ENSG00000186106; -.
DR eggNOG; KOG0508; Eukaryota.
DR GeneTree; ENSGT00940000157094; -.
DR InParanoid; Q86W74; -.
DR OMA; ATEYQGN; -.
DR PhylomeDB; Q86W74; -.
DR TreeFam; TF330790; -.
DR PathwayCommons; Q86W74; -.
DR SignaLink; Q86W74; -.
DR BioGRID-ORCS; 157567; 11 hits in 1079 CRISPR screens.
DR ChiTaRS; ANKRD46; human.
DR GenomeRNAi; 157567; -.
DR Pharos; Q86W74; Tbio.
DR PRO; PR:Q86W74; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q86W74; protein.
DR Bgee; ENSG00000186106; Expressed in endothelial cell and 211 other tissues.
DR ExpressionAtlas; Q86W74; baseline and differential.
DR Genevisible; Q86W74; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..228
FT /note="Ankyrin repeat domain-containing protein 46"
FT /id="PRO_0000244577"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 11..40
FT /note="ANK 1"
FT REPEAT 44..73
FT /note="ANK 2"
FT REPEAT 77..103
FT /note="ANK 3"
FT REPEAT 107..138
FT /note="ANK 4"
FT VAR_SEQ 213..228
FT /note="VSGVLPFVENQPELVH -> RRTLRLGSFARQDRSRIQAI (in isoform
FT 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_060673"
SQ SEQUENCE 228 AA; 25330 MW; F49A43CE49A28A0C CRC64;
MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI
CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV
NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR
TTWQEFVEDL GFWRVLLLIF VIALLSLGIA YYVSGVLPFV ENQPELVH
