ANR46_MOUSE
ID ANR46_MOUSE Reviewed; 228 AA.
AC Q8BTZ5; Q1LZK9; Q8BV97;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Ankyrin repeat domain-containing protein 46;
DE AltName: Full=Ankyrin repeat small protein;
DE Short=ANK-S;
GN Name=Ankrd46;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=SAMP8; TISSUE=Hippocampus;
RA Yamamura N., Koike N., Nomura Y., Sakaki Y., Tashiro T., Furihata C.;
RT "A novel ankyrin-repeat containing gene expressed in SAMP8 hippocampus.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Thymus, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB076382; BAD23946.1; -; mRNA.
DR EMBL; AK079270; BAC37594.1; -; mRNA.
DR EMBL; AK088304; BAC40271.1; -; mRNA.
DR EMBL; AK148049; BAE28312.1; -; mRNA.
DR EMBL; BC086659; AAH86659.1; -; mRNA.
DR EMBL; BC094595; AAH94595.1; -; mRNA.
DR EMBL; BC115842; AAI15843.1; -; mRNA.
DR CCDS; CCDS27429.1; -.
DR RefSeq; NP_780343.1; NM_175134.4.
DR RefSeq; XP_006520237.1; XM_006520174.3.
DR RefSeq; XP_006520238.1; XM_006520175.2.
DR AlphaFoldDB; Q8BTZ5; -.
DR SMR; Q8BTZ5; -.
DR STRING; 10090.ENSMUSP00000052521; -.
DR iPTMnet; Q8BTZ5; -.
DR PhosphoSitePlus; Q8BTZ5; -.
DR EPD; Q8BTZ5; -.
DR MaxQB; Q8BTZ5; -.
DR PaxDb; Q8BTZ5; -.
DR PeptideAtlas; Q8BTZ5; -.
DR PRIDE; Q8BTZ5; -.
DR ProteomicsDB; 282002; -.
DR Antibodypedia; 51983; 70 antibodies from 15 providers.
DR Ensembl; ENSMUST00000057486; ENSMUSP00000052521; ENSMUSG00000048307.
DR GeneID; 68839; -.
DR KEGG; mmu:68839; -.
DR UCSC; uc007vmt.2; mouse.
DR CTD; 157567; -.
DR MGI; MGI:1916089; Ankrd46.
DR VEuPathDB; HostDB:ENSMUSG00000048307; -.
DR eggNOG; KOG0508; Eukaryota.
DR GeneTree; ENSGT00940000157094; -.
DR HOGENOM; CLU_084801_0_0_1; -.
DR InParanoid; Q8BTZ5; -.
DR OMA; ATEYQGN; -.
DR OrthoDB; 1170443at2759; -.
DR PhylomeDB; Q8BTZ5; -.
DR TreeFam; TF330790; -.
DR BioGRID-ORCS; 68839; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Ankrd46; mouse.
DR PRO; PR:Q8BTZ5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BTZ5; protein.
DR Bgee; ENSMUSG00000048307; Expressed in dentate gyrus of hippocampal formation granule cell and 269 other tissues.
DR ExpressionAtlas; Q8BTZ5; baseline and differential.
DR Genevisible; Q8BTZ5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..228
FT /note="Ankyrin repeat domain-containing protein 46"
FT /id="PRO_0000244578"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 11..40
FT /note="ANK 1"
FT REPEAT 44..74
FT /note="ANK 2"
FT REPEAT 77..103
FT /note="ANK 3"
FT REPEAT 107..138
FT /note="ANK 4"
FT CONFLICT 104
FT /note="C -> W (in Ref. 3; AAI15843)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 228 AA; 25223 MW; F9BBC1CE9839483D CRC64;
MSYVFVNDSS QTNVPLLQAC IDGDFTYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI
CQLLHKFGAD PLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV
NKDVIRLLES LEEQEVKGFN RGAHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR
TTWQEFVEDL GFWRVLLLIL VIALLSLGIA YYVSGVLPFV DNQPELVH
