ID   ANR46_RAT               Reviewed;         228 AA.
AC   Q76K24; Q0VGK7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Ankyrin repeat domain-containing protein 46;
DE   AltName: Full=Ankyrin repeat small protein;
DE            Short=ANK-S;
GN   Name=Ankrd46;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Yamamura N., Koike N., Ohkuma Y., Uehara T., Nomura Y., Sakaki Y.,
RA   Tashiro T., Furihata C.;
RT   "Human and rat homologues of a novel gene ank-s expressed in the senescence
RT   accelerated mouse prone 8 (SAMP8).";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AB095364; BAD05179.1; -; mRNA.
DR   EMBL; BC105616; AAI05617.1; -; mRNA.
DR   RefSeq; NP_001013970.1; NM_001013948.1.
DR   RefSeq; XP_006241592.1; XM_006241530.3.
DR   RefSeq; XP_006241593.1; XM_006241531.3.
DR   RefSeq; XP_006241594.1; XM_006241532.3.
DR   AlphaFoldDB; Q76K24; -.
DR   SMR; Q76K24; -.
DR   BioGRID; 256400; 1.
DR   STRING; 10116.ENSRNOP00000034048; -.
DR   PhosphoSitePlus; Q76K24; -.
DR   PaxDb; Q76K24; -.
DR   Ensembl; ENSRNOT00000036904; ENSRNOP00000034048; ENSRNOG00000025504.
DR   GeneID; 299982; -.
DR   KEGG; rno:299982; -.
DR   UCSC; RGD:1309382; rat.
DR   CTD; 157567; -.
DR   RGD; 1309382; Ankrd46.
DR   eggNOG; KOG0508; Eukaryota.
DR   GeneTree; ENSGT00940000157094; -.
DR   HOGENOM; CLU_084801_0_0_1; -.
DR   InParanoid; Q76K24; -.
DR   OMA; ATEYQGN; -.
DR   OrthoDB; 1170443at2759; -.
DR   PhylomeDB; Q76K24; -.
DR   TreeFam; TF330790; -.
DR   PRO; PR:Q76K24; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000025504; Expressed in frontal cortex and 20 other tissues.
DR   Genevisible; Q76K24; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..228
FT                   /note="Ankyrin repeat domain-containing protein 46"
FT                   /id="PRO_0000244580"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..40
FT                   /note="ANK 1"
FT   REPEAT          44..74
FT                   /note="ANK 2"
FT   REPEAT          77..103
FT                   /note="ANK 3"
FT   REPEAT          107..138
FT                   /note="ANK 4"
SQ   SEQUENCE   228 AA;  25181 MW;  18FED588F822528C CRC64;
     MSYVFVNDSS QTNVPLLQAC IDGDFTYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI
     CQLLHKFGAD PLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV
     NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR
     TTWQEFVEDL GFWRVLLLIL VIALLSLGIA YYVSGVLPFV DNQPGLVH