ANR49_BOVIN
ID ANR49_BOVIN Reviewed; 238 AA.
AC Q5EA33;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Ankyrin repeat domain-containing protein 49;
GN Name=ANKRD49;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May have a role in spermatogenesis where it promotes
CC autophagy in response to serum starvation, via the NF-kappaB pathway.
CC {ECO:0000250|UniProtKB:Q8VE42}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VE42}.
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DR EMBL; BT020736; AAX08753.1; -; mRNA.
DR EMBL; BC104574; AAI04575.1; -; mRNA.
DR RefSeq; NP_001014965.1; NM_001014965.2.
DR RefSeq; XP_005215790.1; XM_005215733.3.
DR AlphaFoldDB; Q5EA33; -.
DR SMR; Q5EA33; -.
DR STRING; 9913.ENSBTAP00000045318; -.
DR PaxDb; Q5EA33; -.
DR PRIDE; Q5EA33; -.
DR Ensembl; ENSBTAT00000048242; ENSBTAP00000045318; ENSBTAG00000009176.
DR GeneID; 540949; -.
DR KEGG; bta:540949; -.
DR CTD; 54851; -.
DR VEuPathDB; HostDB:ENSBTAG00000009176; -.
DR VGNC; VGNC:25933; ANKRD49.
DR eggNOG; KOG0512; Eukaryota.
DR GeneTree; ENSGT00390000003919; -.
DR HOGENOM; CLU_000134_19_1_1; -.
DR InParanoid; Q5EA33; -.
DR OMA; SACRWSH; -.
DR OrthoDB; 1546307at2759; -.
DR TreeFam; TF351259; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000009176; Expressed in oocyte and 105 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 2: Evidence at transcript level;
KW ANK repeat; Differentiation; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Spermatogenesis.
FT CHAIN 1..238
FT /note="Ankyrin repeat domain-containing protein 49"
FT /id="PRO_0000244584"
FT REPEAT 77..105
FT /note="ANK 1"
FT REPEAT 106..135
FT /note="ANK 2"
FT REPEAT 139..168
FT /note="ANK 3"
FT REPEAT 172..205
FT /note="ANK 4"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WVL7"
SQ SEQUENCE 238 AA; 27196 MW; 544D9820553E0FE4 CRC64;
MEKEKVNDEK PDPENSLDFS EHFNQLELLE THGHLIPTGT QSLWIGNSDD DEEQDEKTEE
WYQLQEKKME KDPSKLLLWA AEKNRLTTVQ RLLSERATHV NTRDEDKYTP LHRAAYNGHL
DVVRELIAHG ADVHAVTVDG WTPLHSACKW NNARVASFLL QHDADVNAQT KGLLTPLHLA
AGNRDSKDTL ELLLMNRYIK PGLKNSLEET AFDIARRTGI YHYLFEIVEG CTNCSPQS
