ID   HIS7_KAZHU              Reviewed;         226 AA.
AC   H9C4A4;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=HIS3;
OS   Kazachstania humilis (Sour dough yeast) (Candida humilis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=51915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC   STRAIN=CBS 8195;
RX   PubMed=23075797; DOI=10.4014/jmb.1207.07064;
RA   Park E.H., Kwun S.Y., Han S.A., Lee J.S., Kim M.D.;
RT   "Cloning and functional verification of the Candida milleri HIS3 gene
RT   encoding imidazoleglycerol phosphate dehydratase.";
RL   J. Microbiol. Biotechnol. 22:1441-1445(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; JQ228452; AFD62576.1; -; Genomic_DNA.
DR   AlphaFoldDB; H9C4A4; -.
DR   SMR; H9C4A4; -.
DR   BRENDA; 4.2.1.19; 8583.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase.
FT   CHAIN           1..226
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000423022"
FT   REGION          23..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  24216 MW;  8FF18F959E028039 CRC64;
     MTSRTAQVSR ITNETKIQIS ISLTGGPIER PQPSLFASEK GANTAGPDDA SQTTASQTID
     IHTGVGFLDH MIHALAKHAG WSLIVECIGD LHIDDHHTTE DCGIALGEAF KEALGAVRGI
     KRFGSGFAPL DEALSRAVVD ISNRPLAVIE LGLKRERIGD LSCEMIPHFL ESFAEAARIT
     LHVDCLRGFN DHHRSESAFK ALAVAIREAI SSNGTNDVPS TKGVLM