ANR49_MOUSE
ID ANR49_MOUSE Reviewed; 238 AA.
AC Q8VE42; Q9Z2S1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Ankyrin repeat domain-containing protein 49;
DE AltName: Full=Fetal globin-increasing factor;
DE AltName: Full=Fetal globin-inducing factor;
GN Name=Ankrd49; Synonyms=Fgif, Gbif;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC TISSUE=Fetal liver;
RX PubMed=11162141; DOI=10.1006/bcmd.2000.0344;
RA Yang Y., Duan Z., Skarpidi E., Li Q., Papayannopoulou T.,
RA Stamatoyannopoulos G.;
RT "Cloning and characterization of a potential transcriptional activator of
RT human gamma-globin genes.";
RL Blood Cells Mol. Dis. 27:1-15(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=26043108; DOI=10.1371/journal.pone.0128551;
RA Wang H.L., Fan S.S., Pang M., Liu Y.H., Guo M., Liang J.B., Zhang J.L.,
RA Yu B.F., Guo R., Xie J., Zheng G.P.;
RT "The ankyrin repeat domain 49 (ANKRD49) augments autophagy of serum-starved
RT GC-1 cells through the NF-kappaB pathway.";
RL PLoS ONE 10:E0128551-E0128551(2015).
CC -!- FUNCTION: May have a role in spermatogenesis where it promotes
CC autophagy in response to serum starvation, via the NF-kappaB pathway.
CC {ECO:0000269|PubMed:26043108}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26043108}.
CC -!- TISSUE SPECIFICITY: Expressed in spermatogonia, spermatocytes and round
CC spermatids. {ECO:0000269|PubMed:26043108}.
CC -!- DEVELOPMENTAL STAGE: Expressed in liver at embryonic stage 13 dpc, and
CC in liver, brain and lung at 16 dpc (PubMed:11162141). In testis,
CC expression levels steadily increase from 1 week after birth and plateau
CC by 8 weeks after birth (PubMed:26043108). {ECO:0000269|PubMed:11162141,
CC ECO:0000269|PubMed:26043108}.
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DR EMBL; AF028722; AAD04809.1; -; mRNA.
DR EMBL; AK132850; BAE21393.1; -; mRNA.
DR EMBL; BC019777; AAH19777.1; -; mRNA.
DR CCDS; CCDS22826.1; -.
DR RefSeq; NP_001335189.1; NM_001348260.1.
DR RefSeq; NP_062657.2; NM_019683.4.
DR RefSeq; XP_006510566.1; XM_006510503.2.
DR AlphaFoldDB; Q8VE42; -.
DR SMR; Q8VE42; -.
DR BioGRID; 208022; 5.
DR IntAct; Q8VE42; 2.
DR STRING; 10090.ENSMUSP00000034406; -.
DR iPTMnet; Q8VE42; -.
DR PhosphoSitePlus; Q8VE42; -.
DR EPD; Q8VE42; -.
DR MaxQB; Q8VE42; -.
DR PaxDb; Q8VE42; -.
DR PeptideAtlas; Q8VE42; -.
DR PRIDE; Q8VE42; -.
DR ProteomicsDB; 296258; -.
DR Antibodypedia; 51056; 130 antibodies from 20 providers.
DR DNASU; 56503; -.
DR Ensembl; ENSMUST00000034406; ENSMUSP00000034406; ENSMUSG00000031931.
DR Ensembl; ENSMUST00000216037; ENSMUSP00000149874; ENSMUSG00000031931.
DR Ensembl; ENSMUST00000216372; ENSMUSP00000151079; ENSMUSG00000031931.
DR GeneID; 56503; -.
DR KEGG; mmu:56503; -.
DR UCSC; uc009ofa.1; mouse.
DR CTD; 54851; -.
DR MGI; MGI:1930842; Ankrd49.
DR VEuPathDB; HostDB:ENSMUSG00000031931; -.
DR eggNOG; KOG0512; Eukaryota.
DR GeneTree; ENSGT00390000003919; -.
DR HOGENOM; CLU_000134_19_1_1; -.
DR InParanoid; Q8VE42; -.
DR OMA; SACRWSH; -.
DR OrthoDB; 1546307at2759; -.
DR PhylomeDB; Q8VE42; -.
DR TreeFam; TF351259; -.
DR BioGRID-ORCS; 56503; 26 hits in 72 CRISPR screens.
DR ChiTaRS; Ankrd49; mouse.
DR PRO; PR:Q8VE42; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VE42; protein.
DR Bgee; ENSMUSG00000031931; Expressed in spermatid and 245 other tissues.
DR ExpressionAtlas; Q8VE42; baseline and differential.
DR Genevisible; Q8VE42; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Differentiation; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Spermatogenesis.
FT CHAIN 1..238
FT /note="Ankyrin repeat domain-containing protein 49"
FT /id="PRO_0000244586"
FT REPEAT 72..105
FT /note="ANK 1"
FT REPEAT 106..135
FT /note="ANK 2"
FT REPEAT 139..168
FT /note="ANK 3"
FT REPEAT 172..205
FT /note="ANK 4"
FT REGION 38..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WVL7"
FT CONFLICT 13
FT /note="L -> Q (in Ref. 1; AAD04809)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 27111 MW; FA78F49E5D151C30 CRC64;
MEKEKKDDEK PDLENSVDFS EQFNQLELLK THGHLIPTGT QSLWVGNSDE DEEQEEKNEE
WYQLQEKKME KDPSKLLLWA AEKNRLATVQ RLLSEKAAEV NTRDEDEYTP LHRAAYSGHI
DVVRELVAKG ADVHAVTVDG WTPLHSACKW NNTKVASFLL QHDADINAQT KGLLTPLHLA
AGNRDSRDTL ELLLMNRYIK PELKNNSQET ASDIARRTSI YHYLFEIAEG CTNSSPPS
