ID   HIS7_MAGO7              Reviewed;         225 AA.
AC   O42621; A4RA35; G4N1R2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=PTH3; ORFNames=MGG_07528;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=4091-5-8;
RX   PubMed=9574508; DOI=10.1094/mpmi.1998.11.5.404;
RA   Sweigard J.A., Carroll A.M., Farrall L.F., Chumley F.G., Valent B.;
RT   "Magnaporthe grisea pathogenicity genes obtained through insertional
RT   mutagenesis.";
RL   Mol. Plant Microbe Interact. 11:404-412(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB88888.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF027980; AAB88888.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CM001233; EHA51634.1; -; Genomic_DNA.
DR   RefSeq; XP_003711441.1; XM_003711393.1.
DR   AlphaFoldDB; O42621; -.
DR   SMR; O42621; -.
DR   STRING; 318829.MGG_07528T0; -.
DR   PRIDE; O42621; -.
DR   EnsemblFungi; MGG_07528T0; MGG_07528T0; MGG_07528.
DR   GeneID; 2683448; -.
DR   KEGG; mgr:MGG_07528; -.
DR   VEuPathDB; FungiDB:MGG_07528; -.
DR   eggNOG; KOG3143; Eukaryota.
DR   HOGENOM; CLU_044308_3_0_1; -.
DR   InParanoid; O42621; -.
DR   OMA; ARHGLFD; -.
DR   OrthoDB; 1097523at2759; -.
DR   UniPathway; UPA00031; UER00011.
DR   PHI-base; PHI:121; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase; Reference proteome.
FT   CHAIN           1..225
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158239"
SQ   SEQUENCE   225 AA;  23749 MW;  C2CD924969BD4F61 CRC64;
     MASPRWAALA RDTNETKVKL ALSIDGGDLP PDTHPSLLEA AASGHASQSS SSQKISINTG
     IGFLDHMLHA FAKHAGFSLL LTCQGDLHID DHHTAEDVCI ALGDAFKTAL GSAAGIARFG
     FAYCPLDEAL SRAVVDVSNR PFAVVELGLR REKIGDLSCE MIPHCIMSFA TAARLTIHVD
     CIRGENDHHR AESAFKALAV AVRTAVGKVA GREGEVPSTK GTLSV