ANR52_HUMAN
ID ANR52_HUMAN Reviewed; 1076 AA.
AC Q8NB46; A6NE79; B1Q2K2;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C;
DE Short=PP6-ARS-C;
DE Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C;
DE AltName: Full=Ankyrin repeat domain-containing protein 52;
GN Name=ANKRD52;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Jinawath N., Furukawa Y., Nakamura Y.;
RT "Identification of up-regulated genes in gastric cancer.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 510-1076.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1028, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [6]
RP INTERACTION WITH PPP6R1.
RX PubMed=18186651; DOI=10.1021/bi7022877;
RA Stefansson B., Ohama T., Daugherty A.E., Brautigan D.L.;
RT "Protein phosphatase 6 regulatory subunits composed of ankyrin repeat
RT domains.";
RL Biochemistry 47:1442-1451(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1028, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1028, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6)
CC that may be involved in the recognition of phosphoprotein substrates.
CC -!- SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a
CC heterotrimeric complex formed by the catalytic subunit, a SAPS domain-
CC containing subunit (PP6R) and an ankyrin repeat-domain containing
CC regulatory subunit (ARS). Interacts with PPP6R1.
CC {ECO:0000269|PubMed:18186651}.
CC -!- INTERACTION:
CC Q8NB46; Q9UPN7: PPP6R1; NbExp=4; IntAct=EBI-1996119, EBI-359745;
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DR EMBL; AB190990; BAG16262.1; -; mRNA.
DR EMBL; AC073896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471054; EAW96919.1; -; Genomic_DNA.
DR EMBL; AK091555; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44920.1; -.
DR RefSeq; NP_775866.2; NM_173595.3.
DR AlphaFoldDB; Q8NB46; -.
DR SMR; Q8NB46; -.
DR BioGRID; 129540; 80.
DR IntAct; Q8NB46; 36.
DR MINT; Q8NB46; -.
DR STRING; 9606.ENSP00000267116; -.
DR ChEMBL; CHEMBL4105922; -.
DR GlyGen; Q8NB46; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8NB46; -.
DR PhosphoSitePlus; Q8NB46; -.
DR BioMuta; ANKRD52; -.
DR DMDM; 296439443; -.
DR EPD; Q8NB46; -.
DR jPOST; Q8NB46; -.
DR MassIVE; Q8NB46; -.
DR MaxQB; Q8NB46; -.
DR PaxDb; Q8NB46; -.
DR PeptideAtlas; Q8NB46; -.
DR PRIDE; Q8NB46; -.
DR ProteomicsDB; 72730; -.
DR Antibodypedia; 50743; 92 antibodies from 20 providers.
DR DNASU; 283373; -.
DR Ensembl; ENST00000267116.8; ENSP00000267116.7; ENSG00000139645.11.
DR GeneID; 283373; -.
DR KEGG; hsa:283373; -.
DR MANE-Select; ENST00000267116.8; ENSP00000267116.7; NM_173595.4; NP_775866.2.
DR UCSC; uc001skm.5; human.
DR CTD; 283373; -.
DR DisGeNET; 283373; -.
DR GeneCards; ANKRD52; -.
DR HGNC; HGNC:26614; ANKRD52.
DR HPA; ENSG00000139645; Low tissue specificity.
DR neXtProt; NX_Q8NB46; -.
DR OpenTargets; ENSG00000139645; -.
DR PharmGKB; PA143485302; -.
DR VEuPathDB; HostDB:ENSG00000139645; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00950000182908; -.
DR HOGENOM; CLU_000134_58_0_1; -.
DR InParanoid; Q8NB46; -.
DR OMA; ADWLDWR; -.
DR OrthoDB; 1115202at2759; -.
DR PhylomeDB; Q8NB46; -.
DR TreeFam; TF312824; -.
DR PathwayCommons; Q8NB46; -.
DR SignaLink; Q8NB46; -.
DR BioGRID-ORCS; 283373; 103 hits in 1079 CRISPR screens.
DR ChiTaRS; ANKRD52; human.
DR GenomeRNAi; 283373; -.
DR Pharos; Q8NB46; Tbio.
DR PRO; PR:Q8NB46; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NB46; protein.
DR Bgee; ENSG00000139645; Expressed in stromal cell of endometrium and 130 other tissues.
DR Genevisible; Q8NB46; HS.
DR Gene3D; 1.25.40.20; -; 8.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 28.
DR SUPFAM; SSF48403; SSF48403; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 21.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..1076
FT /note="Serine/threonine-protein phosphatase 6 regulatory
FT ankyrin repeat subunit C"
FT /id="PRO_0000244587"
FT REPEAT 7..36
FT /note="ANK 1"
FT REPEAT 40..69
FT /note="ANK 2"
FT REPEAT 73..102
FT /note="ANK 3"
FT REPEAT 106..135
FT /note="ANK 4"
FT REPEAT 139..168
FT /note="ANK 5"
FT REPEAT 172..201
FT /note="ANK 6"
FT REPEAT 205..234
FT /note="ANK 7"
FT REPEAT 238..267
FT /note="ANK 8"
FT REPEAT 271..301
FT /note="ANK 9"
FT REPEAT 305..334
FT /note="ANK 10"
FT REPEAT 338..367
FT /note="ANK 11"
FT REPEAT 371..400
FT /note="ANK 12"
FT REPEAT 422..451
FT /note="ANK 13"
FT REPEAT 455..484
FT /note="ANK 14"
FT REPEAT 488..545
FT /note="ANK 15"
FT REPEAT 549..579
FT /note="ANK 16"
FT REPEAT 584..613
FT /note="ANK 17"
FT REPEAT 617..646
FT /note="ANK 18"
FT REPEAT 651..680
FT /note="ANK 19"
FT REPEAT 687..716
FT /note="ANK 20"
FT REPEAT 720..749
FT /note="ANK 21"
FT REPEAT 753..782
FT /note="ANK 22"
FT REPEAT 790..819
FT /note="ANK 23"
FT REPEAT 822..852
FT /note="ANK 24"
FT REPEAT 857..886
FT /note="ANK 25"
FT REPEAT 890..920
FT /note="ANK 26"
FT REPEAT 924..953
FT /note="ANK 27"
FT REPEAT 960..989
FT /note="ANK 28"
FT REGION 502..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1028
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16964243,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 1075
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BTI7"
FT CONFLICT 686
FT /note="A -> V (in Ref. 4; AK091555)"
FT /evidence="ECO:0000305"
FT CONFLICT 856
FT /note="A -> T (in Ref. 4; AK091555)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1076 AA; 115077 MW; 8CEE6E151956EAFE CRC64;
MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY VGDVPILQLL
LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV NARDKLWQTP LHVAAANRAT
KCAEALAPLL SSLNVADRSG RSALHHAVHS GHLETVNLLL NKGASLNVCD KKERQPLHWA
AFLGHLEVLK LLVARGADLG CKDRKGYGLL HTAAASGQIE VVKYLLRMGA EIDEPNAFGN
TALHIACYLG QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN
YQSKEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG HELLISTLMT
NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI VSSLSNEHVL SAGFDINTPD
NLGRTCLHAA ASGGNVECLN LLLSSGADLR RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA
GVNEADCKGC SPLHYAAASD TYRRAEPHTP SSHDAEEDEP LKESRRKEAF FCLEFLLDNG
ADPSLRDRQG YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTIPVSPLH LAAYNGHCEA
LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK RKWTPLHAAA
ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH VDCVHLLLEK GSTADAADLR
GRTALHRGAV TGCEDCLAAL LDHDAFVLCR DFKGRTPIHL ASACGHTAVL RTLLQAALST
DPLDAGVDYS GYSPMHWASY TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE
MLLGALGAKI VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE
NGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD LGLINATNSA
LQMPLHIAAR NGLASVVQAL LSHGATVLAV DEEGHTPALA CAPNKDVADC LALILSTMKP
FPPKDAVSPF SFSLLKNCSI AAAKTVGGCG ALPHGASCPY SQERPGAIGL DGCYSE
