ANR52_MOUSE
ID ANR52_MOUSE Reviewed; 1076 AA.
AC Q8BTI7; Q148Z3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C;
DE Short=PP6-ARS-C;
DE Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C;
GN Name=Ankrd52;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/HeJ; TISSUE=Brain;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1075, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1075, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6)
CC that may be involved in the recognition of phosphoprotein substrates.
CC {ECO:0000250}.
CC -!- SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a
CC heterotrimeric complex formed by the catalytic subunit, a SAPS domain-
CC containing subunit (PP6R) and an ankyrin repeat-domain containing
CC regulatory subunit (ARS). Interacts with PPP6R1 (By similarity).
CC {ECO:0000250}.
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DR EMBL; AK090124; BAC41105.1; -; mRNA.
DR EMBL; BC117907; AAI17908.1; -; mRNA.
DR EMBL; BC117908; AAI17909.1; -; mRNA.
DR CCDS; CCDS24274.1; -.
DR RefSeq; NP_766378.1; NM_172790.2.
DR AlphaFoldDB; Q8BTI7; -.
DR SMR; Q8BTI7; -.
DR IntAct; Q8BTI7; 1.
DR STRING; 10090.ENSMUSP00000014642; -.
DR iPTMnet; Q8BTI7; -.
DR PhosphoSitePlus; Q8BTI7; -.
DR EPD; Q8BTI7; -.
DR MaxQB; Q8BTI7; -.
DR PaxDb; Q8BTI7; -.
DR PeptideAtlas; Q8BTI7; -.
DR PRIDE; Q8BTI7; -.
DR ProteomicsDB; 296259; -.
DR Antibodypedia; 50743; 92 antibodies from 20 providers.
DR DNASU; 237615; -.
DR Ensembl; ENSMUST00000014642; ENSMUSP00000014642; ENSMUSG00000014498.
DR GeneID; 237615; -.
DR KEGG; mmu:237615; -.
DR UCSC; uc007hmm.1; mouse.
DR CTD; 283373; -.
DR MGI; MGI:2444029; Ankrd52.
DR VEuPathDB; HostDB:ENSMUSG00000014498; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00950000182908; -.
DR HOGENOM; CLU_000134_58_0_1; -.
DR InParanoid; Q8BTI7; -.
DR OMA; ADWLDWR; -.
DR OrthoDB; 1115202at2759; -.
DR PhylomeDB; Q8BTI7; -.
DR TreeFam; TF312824; -.
DR BioGRID-ORCS; 237615; 13 hits in 72 CRISPR screens.
DR ChiTaRS; Ankrd52; mouse.
DR PRO; PR:Q8BTI7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BTI7; protein.
DR Bgee; ENSMUSG00000014498; Expressed in rostral migratory stream and 97 other tissues.
DR ExpressionAtlas; Q8BTI7; baseline and differential.
DR Gene3D; 1.25.40.20; -; 10.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 8.
DR Pfam; PF13637; Ank_4; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 28.
DR SUPFAM; SSF48403; SSF48403; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 21.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..1076
FT /note="Serine/threonine-protein phosphatase 6 regulatory
FT ankyrin repeat subunit C"
FT /id="PRO_0000244588"
FT REPEAT 7..36
FT /note="ANK 1"
FT REPEAT 40..69
FT /note="ANK 2"
FT REPEAT 73..102
FT /note="ANK 3"
FT REPEAT 106..135
FT /note="ANK 4"
FT REPEAT 139..168
FT /note="ANK 5"
FT REPEAT 172..201
FT /note="ANK 6"
FT REPEAT 205..234
FT /note="ANK 7"
FT REPEAT 238..267
FT /note="ANK 8"
FT REPEAT 271..301
FT /note="ANK 9"
FT REPEAT 305..334
FT /note="ANK 10"
FT REPEAT 338..367
FT /note="ANK 11"
FT REPEAT 371..400
FT /note="ANK 12"
FT REPEAT 422..451
FT /note="ANK 13"
FT REPEAT 455..484
FT /note="ANK 14"
FT REPEAT 488..545
FT /note="ANK 15"
FT REPEAT 549..579
FT /note="ANK 16"
FT REPEAT 584..613
FT /note="ANK 17"
FT REPEAT 617..646
FT /note="ANK 18"
FT REPEAT 651..680
FT /note="ANK 19"
FT REPEAT 687..716
FT /note="ANK 20"
FT REPEAT 720..749
FT /note="ANK 21"
FT REPEAT 753..782
FT /note="ANK 22"
FT REPEAT 790..819
FT /note="ANK 23"
FT REPEAT 822..852
FT /note="ANK 24"
FT REPEAT 857..886
FT /note="ANK 25"
FT REPEAT 890..920
FT /note="ANK 26"
FT REPEAT 924..953
FT /note="ANK 27"
FT REPEAT 960..989
FT /note="ANK 28"
FT MOD_RES 1028
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NB46"
FT MOD_RES 1075
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 1076 AA; 115032 MW; 058FE2C95E1A5682 CRC64;
MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY VGDVPILQLL
LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV NARDKLWQTP LHVAAANRAT
KCAEALAPLL SSLNVADRSG RSALHHAVHS GHLETVNLLL NKGASLNVCD KKERQPLHWA
AFLGHLEVLK LLVARGADLS CKDRKGYGLL HTAAASGQIE VVKHLLRMGA EIDEPNAFGN
TALHIACYLG QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN
YQSKEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG HELLISTLMT
NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI VSSLSNEHVL SAGFDINTPD
SLGRTCLHAA ASGGNVECLN LLLSSGADLR RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA
GVNEADCKGC SPLHYAAASD TYRRAEPHTA SSHDAEEDEL LKESRRKEAF FCLEFLLDNG
ADPSLRDRQG YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTVPVSPLH LAAYNGHCEA
LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK RKWTPLHAAA
ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH VDCVHLLLEK GSTADAADLR
GRTALHRGAV TGCEDCLAAL LDHDAFVLCR DFKGRTPIHL ASACGHTAVL RTLLQAALST
DPLDAGVDYS GYSPMHWASY TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE
MLLGALGAKI VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE
SGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD LGLINATNSA
LQMPLHIAAR NGLASVVQAL LSRGATVLAV DEEGHTPALA CAPNKDVADC LALILSTMKP
FPPKDAVSPF SFSLLKNCGI AAAKTVGGCG ALPHGASCPY SQERHGAIGL DGCYSE
