ID   ANR53_MACFA             Reviewed;         496 AA.
AC   Q4R739;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Ankyrin repeat domain-containing protein 53;
GN   Name=ANKRD53; ORFNames=QtsA-16406;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal progression through mitosis. Involved in
CC       chromosome alignment and cytokinesis via regulation of microtubules
CC       polymerization. {ECO:0000250|UniProtKB:Q8N9V6}.
CC   -!- SUBUNIT: Interacts with PSRC1; recruited by PSRC1 to the spindle during
CC       mitosis. {ECO:0000250|UniProtKB:Q8N9V6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q8N9V6}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q8N9V6}. Note=Localizes at the spindle around
CC       the centrosome at prophase and prometaphase and at the spindle poles at
CC       metaphase and anaphase. {ECO:0000250|UniProtKB:Q8N9V6}.
CC   -!- PTM: Phosphorylated during mitosis. {ECO:0000250|UniProtKB:Q8N9V6}.
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DR   EMBL; AB168990; BAE01085.1; -; mRNA.
DR   RefSeq; NP_001270649.1; NM_001283720.1.
DR   AlphaFoldDB; Q4R739; -.
DR   SMR; Q4R739; -.
DR   STRING; 9541.XP_005575694.1; -.
DR   Ensembl; ENSMFAT00000066588; ENSMFAP00000016058; ENSMFAG00000031224.
DR   GeneID; 101867094; -.
DR   CTD; 79998; -.
DR   eggNOG; KOG4177; Eukaryota.
DR   GeneTree; ENSGT00390000005650; -.
DR   Proteomes; UP000233100; Chromosome 13.
DR   Bgee; ENSMFAG00000031224; Expressed in multicellular organism.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0031116; P:positive regulation of microtubule polymerization; ISS:UniProtKB.
DR   GO; GO:1902412; P:regulation of mitotic cytokinesis; ISS:UniProtKB.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR042335; ANKRD53.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24160; PTHR24160; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..496
FT                   /note="Ankyrin repeat domain-containing protein 53"
FT                   /id="PRO_0000274491"
FT   REPEAT          105..135
FT                   /note="ANK 1"
FT   REPEAT          139..172
FT                   /note="ANK 2"
FT   REPEAT          176..205
FT                   /note="ANK 3"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  56088 MW;  1BC8B410CB56256D CRC64;
     MASAGSTARR AGSGSWHSER GEGRGARPQP TPHGSMQRAN KVSLKATWTD AESKQPRPSE
     ESDQTTIDQT AIRSYYQLFA AAVGNVEWLR FCLNQSLREI PTDYKGFTAI HFAAQRGKLA
     CLQVLVEEYK FPVNLLTNNS QTPLHLVIHK DNTTVALPCI YYLLEKGAAL NAQTCNGCTP
     LHLAVREGLL DCVKVLVQSG ANVHAQDAMG YKPIDFCKIW NHRACARFLK DAMWKKDKKD
     FACEMRKMKT LKSQLALMEY NYLIEYQKEH KILREAAIRK WLHGKLHPGH SLVSNTKQAR
     ATALSKTPEQ RGSQCSSSFH PSVEARLQCI PQPTEMPKPI YRKSTIKRPT MWNVSNNPAR
     PPTTKISHSQ GIRLGVHPDP SPEHDFSSFL EVRPDRHGGA WLHTVDGHWV APVPRLPFEV
     LLRMLYPHVR PYRMKVPQGF YPISMREVPR KRHLGDDTFW TDTLAMNLRD TFDEAFLAAV
     RSHQGLPALP SPQINP