ID   HIS7_PHARH              Reviewed;         205 AA.
AC   O94153;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=HIS3;
OS   Phaffia rhodozyma (Yeast) (Xanthophyllomyces dendrorhous).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Cystofilobasidiales; Mrakiaceae; Phaffia.
OX   NCBI_TaxID=264483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96594 / BCRC 22365 / CBS 6938 / JCM 9684 / VKM Y-2793;
RA   Villadsen I.S., Langkjer R., Lavritsen J.;
RT   "HIS3 gene from Phaffia rhodozyma.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; AF114492; AAD14685.1; -; Genomic_DNA.
DR   AlphaFoldDB; O94153; -.
DR   SMR; O94153; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase.
FT   CHAIN           1..205
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158241"
SQ   SEQUENCE   205 AA;  22127 MW;  DBB3CE157D6C713C CRC64;
     MSAGLPIRTA TVTRNTNETQ IVCSISLDHT PGVDQQIIDI QTGIGFLNHM LHAMAKHGNM
     SLTLHCKGDL EIDDHHTAED CALALGEAFK LALGERRGIR RYGTGFAPLD EALSRAVLDI
     SSRPYFCGDL PFTREKIGDL STEMIPHVFE SFATAAGVTL HVDCIRGVNN HHIAEASFKA
     LALAIREAIT RTGGNDVPST KGVLL