ID   HIS7_PHYPR              Reviewed;         452 AA.
AC   P28624;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   29-SEP-2021, entry version 94.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=HIS3;
OS   Phytophthora parasitica (Potato buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 1829 / CBS 411.87;
RA   Baltrusch-Weiter M., Karlovsky P., Prell H.H.;
RT   "HIS3 gene of Phytophthora parasitica.";
RL   Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z11591; CAA77675.1; -; Genomic_DNA.
DR   PIR; S22199; S22199.
DR   VEuPathDB; FungiDB:PPTG_19825; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 1.10.150.240; -; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006439; HAD-SF_hydro_IA.
DR   InterPro; IPR006438; HAD-SF_TIGR01548.
DR   InterPro; IPR041492; HAD_2.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006543; Histidinol-phos.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR023198; PGP-like_dom2.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF13419; HAD_2; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01548; HAD-SF-IA-hyp1; 1.
DR   TIGRFAMs; TIGR01549; HAD-SF-IA-v1; 1.
DR   TIGRFAMs; TIGR01656; Histidinol-ppas; 1.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase;
KW   Multifunctional enzyme.
FT   CHAIN           1..452
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158242"
FT   REGION          1..233
FT                   /note="Unknown activity"
FT   REGION          234..452
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
SQ   SEQUENCE   452 AA;  47963 MW;  CAE66BE32A9E53A1 CRC64;
     MASPVQALLL DMDGVMAEVS QSYRQAIIDT ARHFGVSVTH EDIDHTKLAG NANNDWQLTH
     RLVVDGLNGA SSAPTLEAVT AQFEALYQGV GNTLGLCELE TLLTPKGLLR ELHRRQPKGM
     AVVTGRPRKD CAKFLTTHGI EDLFPVQIWL EDCPPKPSPE PILLALKALG VEACHAAMVG
     DTVDDIIAGR KAGAVAYGVL TPQTYAKSIL EQTPAAIGKV LEQVGASVVL TPGLGELLDL
     VPAVPTASKA PTVNGKSGVR EANISRVTKE TSISVKLSLD GTGKSKVSSG IGFLDHMLTA
     LAKHSRFDLE LDCKGDTWID DHHTTEDCAL TLGEAFDVAL GDRAGIARFG SACVPLDEAL
     SRAIVDISSR AHSEINLQLV RPSVGELSSE MITHFFESFA SAALXTLHVD VLRGRNDHHR
     AEASFKALAV ALRTAVKHDA TAGVPSTKGV LA