ID   HIS7_PICPA              Reviewed;         224 AA.
AC   Q92447;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=HIS3;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76273 / CBS 7435 / CECT 11407 / NRRL Y-11430;
RA   Logghe M., Molemans F., Contreras R., Fiers W.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76273 / CBS 7435 / CECT 11407 / NRRL Y-11430;
RX   PubMed=9818724;
RX   DOI=10.1002/(sici)1097-0061(19980630)14:9<861::aid-yea276>3.0.co;2-n;
RA   Cosano I.C., Alvarez P., Molina M., Nombela C.;
RT   "Cloning and sequence analysis of the Pichia pastoris TRP1, IPP1 and HIS3
RT   genes.";
RL   Yeast 14:861-867(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; U69170; AAB18319.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q92447; -.
DR   SMR; Q92447; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase.
FT   CHAIN           1..224
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158244"
SQ   SEQUENCE   224 AA;  24166 MW;  D52D1033384CA06A CRC64;
     MTGEHKRSSL IKRITNETKI QIALSLDGGP VSLAQSLFKD KDYSAEHAAQ ATSSQFISVN
     TGIGFLDHML HALAKHGGWS VIIECVGDLH IDDHHSAEDT GIALGMAFKE ALGHVRGIKR
     FGSGFAPLDE ALSRAVIDMS NRPYAVVDLG LKREKIGDLS CEMIPHVLES FAQGAHVTMH
     VDCLRGFNDH HRAESAFKAL AIAIKEAISS NGTDDIPSTK GVLF