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HIS7_PYRFU
ID   HIS7_PYRFU              Reviewed;         176 AA.
AC   P58880;
DT   24-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   24-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_00076};
DE            Short=IGPD {ECO:0000255|HAMAP-Rule:MF_00076};
DE            EC=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_00076};
GN   Name=hisB {ECO:0000255|HAMAP-Rule:MF_00076}; OrderedLocusNames=PF1660;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00076};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC       {ECO:0000255|HAMAP-Rule:MF_00076}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00076}.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000255|HAMAP-Rule:MF_00076}.
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DR   EMBL; AE009950; AAL81784.1; -; Genomic_DNA.
DR   RefSeq; WP_011012806.1; NZ_CP023154.1.
DR   PDB; 5DNL; X-ray; 1.53 A; A/B/C=1-176.
DR   PDB; 5DNX; X-ray; 1.80 A; A/B/C=1-176.
DR   PDBsum; 5DNL; -.
DR   PDBsum; 5DNX; -.
DR   AlphaFoldDB; P58880; -.
DR   SMR; P58880; -.
DR   STRING; 186497.PF1660; -.
DR   EnsemblBacteria; AAL81784; AAL81784; PF1660.
DR   GeneID; 41713488; -.
DR   KEGG; pfu:PF1660; -.
DR   PATRIC; fig|186497.12.peg.1726; -.
DR   eggNOG; arCOG04398; Archaea.
DR   HOGENOM; CLU_044308_2_1_2; -.
DR   OMA; ARHGLFD; -.
DR   OrthoDB; 91418at2157; -.
DR   PhylomeDB; P58880; -.
DR   UniPathway; UPA00031; UER00011.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis;
KW   Lyase; Reference proteome.
FT   CHAIN           1..176
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158195"
FT   STRAND          2..4
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   STRAND          6..14
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   HELIX           25..38
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   STRAND          42..50
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   HELIX           51..69
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   STRAND          72..74
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   STRAND          77..84
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   STRAND          87..94
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   STRAND          100..104
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   HELIX           116..130
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   STRAND          133..140
FT                   /evidence="ECO:0007829|PDB:5DNL"
FT   HELIX           144..162
FT                   /evidence="ECO:0007829|PDB:5DNL"
SQ   SEQUENCE   176 AA;  19736 MW;  DF449AA227D09133 CRC64;
     MRRTTKETDI IVEIGKKGEI KTNDLILDHM LTAFAFYLGK DMRITATYDL RHHLWEDIGI
     TLGEALRENL PEKFTRFGNA IMPMDDALVL VSVDISNRPY ANVDVNIKDA EEGFAVSLLK
     EFVWGLARGL RATIHIKQLS GENAHHIVEA AFKGLGMALR VATKESERVE STKGVL
 
 
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