ANR60_HUMAN
ID ANR60_HUMAN Reviewed; 345 AA.
AC Q9BZ19; Q4VXE6;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Ankyrin repeat domain-containing protein 60;
GN Name=ANKRD60; Synonyms=C20orf86;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
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DR EMBL; AL354776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS77596.1; -.
DR RefSeq; NP_001291298.1; NM_001304369.1.
DR AlphaFoldDB; Q9BZ19; -.
DR SMR; Q9BZ19; -.
DR STRING; 9606.ENSP00000396747; -.
DR iPTMnet; Q9BZ19; -.
DR PhosphoSitePlus; Q9BZ19; -.
DR BioMuta; ANKRD60; -.
DR DMDM; 158520015; -.
DR EPD; Q9BZ19; -.
DR jPOST; Q9BZ19; -.
DR MassIVE; Q9BZ19; -.
DR PaxDb; Q9BZ19; -.
DR PeptideAtlas; Q9BZ19; -.
DR PRIDE; Q9BZ19; -.
DR ProteomicsDB; 79752; -.
DR Antibodypedia; 67473; 49 antibodies from 10 providers.
DR DNASU; 140731; -.
DR Ensembl; ENST00000457363.1; ENSP00000396747.1; ENSG00000124227.5.
DR GeneID; 140731; -.
DR KEGG; hsa:140731; -.
DR MANE-Select; ENST00000457363.2; ENSP00000396747.1; NM_001304369.2; NP_001291298.1.
DR UCSC; uc061xzo.1; human.
DR CTD; 140731; -.
DR GeneCards; ANKRD60; -.
DR HGNC; HGNC:16217; ANKRD60.
DR HPA; ENSG00000124227; Tissue enriched (testis).
DR neXtProt; NX_Q9BZ19; -.
DR OpenTargets; ENSG00000124227; -.
DR PharmGKB; PA162376674; -.
DR VEuPathDB; HostDB:ENSG00000124227; -.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00390000015137; -.
DR HOGENOM; CLU_077152_0_0_1; -.
DR InParanoid; Q9BZ19; -.
DR OMA; ETGEMFR; -.
DR OrthoDB; 1124937at2759; -.
DR PhylomeDB; Q9BZ19; -.
DR TreeFam; TF351265; -.
DR PathwayCommons; Q9BZ19; -.
DR BioGRID-ORCS; 140731; 2 hits in 170 CRISPR screens.
DR GenomeRNAi; 140731; -.
DR Pharos; Q9BZ19; Tdark.
DR PRO; PR:Q9BZ19; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BZ19; protein.
DR Bgee; ENSG00000124227; Expressed in right testis and 2 other tissues.
DR Genevisible; Q9BZ19; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR039323; ANKRD60.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22677; PTHR22677; 1.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..345
FT /note="Ankyrin repeat domain-containing protein 60"
FT /id="PRO_0000414175"
FT DOMAIN 96..172
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REPEAT 219..249
FT /note="ANK 1"
FT REPEAT 252..281
FT /note="ANK 2"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 295
FT /note="R -> C (in dbSNP:rs584855)"
FT /id="VAR_014400"
SQ SEQUENCE 345 AA; 37630 MW; FB3B25F546F5A8F5 CRC64;
MTRGRAWGMR RAAAGAGGAR AAGPTGGASR LHPNAGRRSG ARAGAQGCGG PRVGSADSRA
LPAQPLACAR GRSQRLVCDP KAASALPDLA PDVFVLRVRL EETGEMFRVA NCRGDMTVRE
LKEELDLMVG IPFNLQRLQY LDEGVLMDDT TLKFHDVVPG GIISLCIWHH DGWTELVLAA
VEGDPSKLSC LGLTEDSFYR TANSEHFEGE KWKHWTSQRA FVALYVASHR GHFDAVQYLL
EHGASCLSRS PLGRTPLHVA AAMGRSDCII LLLQHGASIH DRDAKGETPI SIAHRLNHTL
SERQMVLLHR IAKSGIRDLN DLVMKNALQR VKSGFRSEKM TMTPH
