ID   ANR61_HUMAN             Reviewed;         418 AA.
AC   A6NGH8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Ankyrin repeat domain-containing protein 61;
GN   Name=ANKRD61;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
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DR   EMBL; AC005995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS64590.1; -.
DR   RefSeq; NP_001258629.1; NM_001271700.1.
DR   AlphaFoldDB; A6NGH8; -.
DR   SMR; A6NGH8; -.
DR   STRING; 9606.ENSP00000386502; -.
DR   PhosphoSitePlus; A6NGH8; -.
DR   BioMuta; ANKRD61; -.
DR   PaxDb; A6NGH8; -.
DR   PeptideAtlas; A6NGH8; -.
DR   PRIDE; A6NGH8; -.
DR   Antibodypedia; 49311; 56 antibodies from 12 providers.
DR   DNASU; 100310846; -.
DR   Ensembl; ENST00000409061.2; ENSP00000386502.1; ENSG00000157999.6.
DR   GeneID; 100310846; -.
DR   KEGG; hsa:100310846; -.
DR   MANE-Select; ENST00000409061.2; ENSP00000386502.1; NM_001271700.2; NP_001258629.1.
DR   UCSC; uc031swn.2; human.
DR   CTD; 100310846; -.
DR   DisGeNET; 100310846; -.
DR   GeneCards; ANKRD61; -.
DR   HGNC; HGNC:22467; ANKRD61.
DR   HPA; ENSG00000157999; Group enriched (bone marrow, testis).
DR   neXtProt; NX_A6NGH8; -.
DR   OpenTargets; ENSG00000157999; -.
DR   VEuPathDB; HostDB:ENSG00000157999; -.
DR   eggNOG; KOG4177; Eukaryota.
DR   GeneTree; ENSGT00840000130004; -.
DR   HOGENOM; CLU_054056_0_0_1; -.
DR   InParanoid; A6NGH8; -.
DR   OMA; AINESSM; -.
DR   OrthoDB; 780429at2759; -.
DR   PhylomeDB; A6NGH8; -.
DR   TreeFam; TF352214; -.
DR   PathwayCommons; A6NGH8; -.
DR   SignaLink; A6NGH8; -.
DR   BioGRID-ORCS; 100310846; 8 hits in 1022 CRISPR screens.
DR   GenomeRNAi; 100310846; -.
DR   Pharos; A6NGH8; Tdark.
DR   PRO; PR:A6NGH8; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A6NGH8; protein.
DR   Bgee; ENSG00000157999; Expressed in bone marrow and 105 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
PE   4: Predicted;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..418
FT                   /note="Ankyrin repeat domain-containing protein 61"
FT                   /id="PRO_0000328762"
FT   REPEAT          27..57
FT                   /note="ANK 1"
FT   REPEAT          75..104
FT                   /note="ANK 2"
FT   REPEAT          132..161
FT                   /note="ANK 3"
FT   REPEAT          167..196
FT                   /note="ANK 4"
FT   REPEAT          200..229
FT                   /note="ANK 5"
FT   REPEAT          234..273
FT                   /note="ANK 6"
FT   REPEAT          277..306
FT                   /note="ANK 7"
FT   REPEAT          310..343
FT                   /note="ANK 8"
SQ   SEQUENCE   418 AA;  46141 MW;  DD079DA78FFE4613 CRC64;
     MGNITRKGSR DLVVDSAKSL EDGPSAALHS KLYEAIMRED CTTIEVLLRN HPVNQPITIL
     PNSASNRLLL TQPTESIIPI HLAAKYHKAQ SLLCLLRHGA DPEVRDTTGL TTLNLMLLHW
     PVTSTTWAKP GNRTHRILTD IQNSSITCLR ILCAHGAQVN TQGEISNKRS PLHLAIAYGC
     YPVLSILTQN GADVNAINEA SMTPLHMAAN MLNKEMMETL IAYGANVNCA VSSTGNTPLK
     LAVCTASSKA GRLLGAGVSC IRLLLTHGAK VNAQDYKGQT AIHEACFGGR EAIINLLLEF
     EANVNILTRN GESPIYMYLQ RSCNVRDTAL LARLLYHTYP LRMTNNQGIL PAGIMLPEFR
     LLRDTLIKQS QKPLSLQGIC KRNIRNIYGE KYKQHLKQFL PVTIWNSVYC CYDLAYTS