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ANR61_MOUSE
ID   ANR61_MOUSE             Reviewed;         421 AA.
AC   Q9CQM6; Q80W77;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Ankyrin repeat domain-containing protein 61;
GN   Name=Ankrd61;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9CQM6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9CQM6-2; Sequence=VSP_032775;
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DR   EMBL; AK014929; BAB29624.1; -; mRNA.
DR   EMBL; AK017053; BAB30569.1; -; mRNA.
DR   EMBL; BC052346; AAH52346.1; -; mRNA.
DR   CCDS; CCDS39373.1; -. [Q9CQM6-1]
DR   CCDS; CCDS80460.1; -. [Q9CQM6-2]
DR   RefSeq; NP_001297701.1; NM_001310772.1. [Q9CQM6-2]
DR   RefSeq; NP_080008.1; NM_025732.4. [Q9CQM6-1]
DR   AlphaFoldDB; Q9CQM6; -.
DR   SMR; Q9CQM6; -.
DR   STRING; 10090.ENSMUSP00000106345; -.
DR   iPTMnet; Q9CQM6; -.
DR   PhosphoSitePlus; Q9CQM6; -.
DR   PaxDb; Q9CQM6; -.
DR   PRIDE; Q9CQM6; -.
DR   ProteomicsDB; 282121; -. [Q9CQM6-1]
DR   ProteomicsDB; 282122; -. [Q9CQM6-2]
DR   Antibodypedia; 49311; 56 antibodies from 12 providers.
DR   DNASU; 66729; -.
DR   Ensembl; ENSMUST00000079624; ENSMUSP00000078571; ENSMUSG00000029607. [Q9CQM6-2]
DR   Ensembl; ENSMUST00000110717; ENSMUSP00000106345; ENSMUSG00000029607. [Q9CQM6-1]
DR   GeneID; 66729; -.
DR   KEGG; mmu:66729; -.
DR   UCSC; uc009akv.1; mouse. [Q9CQM6-1]
DR   CTD; 100310846; -.
DR   MGI; MGI:1913979; Ankrd61.
DR   VEuPathDB; HostDB:ENSMUSG00000029607; -.
DR   eggNOG; KOG4177; Eukaryota.
DR   GeneTree; ENSGT00840000130004; -.
DR   HOGENOM; CLU_054056_0_0_1; -.
DR   InParanoid; Q9CQM6; -.
DR   OMA; AINESSM; -.
DR   OrthoDB; 780429at2759; -.
DR   PhylomeDB; Q9CQM6; -.
DR   TreeFam; TF352214; -.
DR   BioGRID-ORCS; 66729; 2 hits in 71 CRISPR screens.
DR   PRO; PR:Q9CQM6; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9CQM6; protein.
DR   Bgee; ENSMUSG00000029607; Expressed in seminiferous tubule of testis and 37 other tissues.
DR   ExpressionAtlas; Q9CQM6; baseline and differential.
DR   Genevisible; Q9CQM6; MM.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF13637; Ank_4; 2.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ANK repeat; DNA-binding; Reference proteome; Repeat.
FT   CHAIN           1..421
FT                   /note="Ankyrin repeat domain-containing protein 61"
FT                   /id="PRO_0000328763"
FT   REPEAT          27..57
FT                   /note="ANK 1"
FT   REPEAT          74..103
FT                   /note="ANK 2"
FT   REPEAT          107..146
FT                   /note="ANK 3"
FT   REPEAT          166..195
FT                   /note="ANK 4"
FT   REPEAT          199..228
FT                   /note="ANK 5"
FT   REPEAT          233..272
FT                   /note="ANK 6"
FT   REPEAT          276..305
FT                   /note="ANK 7"
FT   REPEAT          309..342
FT                   /note="ANK 8"
FT   VAR_SEQ         1..71
FT                   /note="MGNITKRGSRDLVADGATLVEESLATTLHSKLYEAIIKEDCNTIKTLLRNHP
FT                   VNQPLTILANSTRYRLLSQ -> MDGWNTACVAGRRVPSSSQNTPTATMSCK (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_032775"
SQ   SEQUENCE   421 AA;  46588 MW;  7610ACAEA9A36654 CRC64;
     MGNITKRGSR DLVADGATLV EESLATTLHS KLYEAIIKED CNTIKTLLRN HPVNQPLTIL
     ANSTRYRLLS QQTQPIFPIH LAAEYRKPQS LLCLLQHGAD PEVRDAQGFT TLHLMLLNWP
     ASSTTWSKPS TQIQKILMDI QNNAVLCLCI LCDHGAQVNA RVDNSNKHSA LHLAIIHGTY
     PVLSFLAQNG AQVNATNESS MTPLHMAADI LNKNMIETLI AFGANVNCAI SSTGNTALKL
     AVCTASSKVG RLLAAGVGCI RLLLNNGAQV NAQDHEGQTA LHEACFGGRE AIISLLLEFE
     ANVNILTRNG ESPIYMYLQR SSNIRDRSLL ARLLYRTYPL RLSNKQGILP AGIMLPEYQL
     LRETLVKLSK KPLTLEAICK RSIRNVYGEK YKFHLEKLLP AKLWNSIYGI YDLTYLLKGE
     P
 
 
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