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HIS7_SCHPO
ID   HIS7_SCHPO              Reviewed;         216 AA.
AC   P40374;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 138.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=his5; ORFNames=SPBC21H7.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7732725; DOI=10.1002/yea.320110207;
RA   Erickson F.L., Hannig E.M.;
RT   "Characterization of Schizosaccharomyces pombe his1 and his5 cDNAs.";
RL   Yeast 11:157-167(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10407269;
RX   DOI=10.1002/(sici)1097-0061(199907)15:10a<893::aid-yea430>3.0.co;2-s;
RA   Xiang Z., Lyne M.H., Wood V., Rajandream M.A., Barrell B.G., Aves S.J.;
RT   "DNA sequencing and analysis of a 67.4 kb region from the right arm of
RT   Schizosaccharomyces pombe chromosome II reveals 28 open reading frames
RT   including the genes his5, pol5, ppa2, rip1, rpb8 and skb1.";
RL   Yeast 15:893-901(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; U07831; AAA92791.1; -; mRNA.
DR   EMBL; CU329671; CAA18867.1; -; Genomic_DNA.
DR   PIR; S55077; S55077.
DR   RefSeq; NP_595932.1; NM_001021840.2.
DR   AlphaFoldDB; P40374; -.
DR   SMR; P40374; -.
DR   BioGRID; 277200; 10.
DR   STRING; 4896.SPBC21H7.07c.1; -.
DR   iPTMnet; P40374; -.
DR   MaxQB; P40374; -.
DR   PaxDb; P40374; -.
DR   EnsemblFungi; SPBC21H7.07c.1; SPBC21H7.07c.1:pep; SPBC21H7.07c.
DR   GeneID; 2540675; -.
DR   KEGG; spo:SPBC21H7.07c; -.
DR   PomBase; SPBC21H7.07c; his5.
DR   VEuPathDB; FungiDB:SPBC21H7.07c; -.
DR   eggNOG; KOG3143; Eukaryota.
DR   HOGENOM; CLU_044308_3_0_1; -.
DR   InParanoid; P40374; -.
DR   OMA; ARHGLFD; -.
DR   PhylomeDB; P40374; -.
DR   UniPathway; UPA00031; UER00011.
DR   PRO; PR:P40374; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; ISO:PomBase.
DR   GO; GO:0000105; P:histidine biosynthetic process; IBA:GO_Central.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..216
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158247"
FT   MOD_RES         211
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   216 AA;  23520 MW;  2A30A1126FB1ED32 CRC64;
     MRRAFVERNT NETKISVAIA LDKAPLPEES NFIDELITSK HANQKGEQVI QVDTGIGFLD
     HMYHALAKHA GWSLRLYSRG DLIIDDHHTA EDTAIALGIA FKQAMGNFAG VKRFGHAYCP
     LDEALSRSVV DLSGRPYAVI DLGLKREKVG ELSCEMIPHL LYSFSVAAGI TLHVTCLYGS
     NDHHRAESAF KSLAVAMRAA TSLTGSSEVP STKGVL
 
 
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