ID   ANR63_HUMAN             Reviewed;         380 AA.
AC   C9JTQ0;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Ankyrin repeat domain-containing protein 63 {ECO:0000312|HGNC:HGNC:40027};
GN   Name=ANKRD63 {ECO:0000312|HGNC:HGNC:40027};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
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DR   EMBL; AC020658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53929.1; -.
DR   RefSeq; NP_001177408.1; NM_001190479.2.
DR   AlphaFoldDB; C9JTQ0; -.
DR   SMR; C9JTQ0; -.
DR   STRING; 9606.ENSP00000399547; -.
DR   iPTMnet; C9JTQ0; -.
DR   PhosphoSitePlus; C9JTQ0; -.
DR   BioMuta; ANKRD63; -.
DR   MassIVE; C9JTQ0; -.
DR   PaxDb; C9JTQ0; -.
DR   PeptideAtlas; C9JTQ0; -.
DR   PRIDE; C9JTQ0; -.
DR   ProteomicsDB; 11621; -.
DR   Antibodypedia; 70339; 51 antibodies from 9 providers.
DR   DNASU; 100131244; -.
DR   Ensembl; ENST00000434396.2; ENSP00000399547.1; ENSG00000230778.2.
DR   GeneID; 100131244; -.
DR   KEGG; hsa:100131244; -.
DR   MANE-Select; ENST00000434396.2; ENSP00000399547.1; NM_001190479.3; NP_001177408.1.
DR   UCSC; uc021sjf.1; human.
DR   CTD; 100131244; -.
DR   GeneCards; ANKRD63; -.
DR   HGNC; HGNC:40027; ANKRD63.
DR   HPA; ENSG00000230778; Tissue enriched (brain).
DR   neXtProt; NX_C9JTQ0; -.
DR   VEuPathDB; HostDB:ENSG00000230778; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000163025; -.
DR   HOGENOM; CLU_042924_0_0_1; -.
DR   InParanoid; C9JTQ0; -.
DR   OMA; PNPWQAG; -.
DR   OrthoDB; 1073736at2759; -.
DR   PhylomeDB; C9JTQ0; -.
DR   TreeFam; TF333311; -.
DR   PathwayCommons; C9JTQ0; -.
DR   SignaLink; C9JTQ0; -.
DR   BioGRID-ORCS; 100131244; 10 hits in 252 CRISPR screens.
DR   GenomeRNAi; 100131244; -.
DR   Pharos; C9JTQ0; Tdark.
DR   PRO; PR:C9JTQ0; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; C9JTQ0; protein.
DR   Bgee; ENSG00000230778; Expressed in nucleus accumbens and 27 other tissues.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..380
FT                   /note="Ankyrin repeat domain-containing protein 63"
FT                   /id="PRO_0000411002"
FT   REPEAT          11..40
FT                   /note="ANK 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          46..79
FT                   /note="ANK 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          83..112
FT                   /note="ANK 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          116..145
FT                   /note="ANK 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          153..182
FT                   /note="ANK 5"
FT                   /evidence="ECO:0000255"
FT   REGION          181..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         193
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2ARS0"
FT   MOD_RES         294
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2ARS0"
SQ   SEQUENCE   380 AA;  39620 MW;  68DE84AAC8CD0106 CRC64;
     MLKPKDLCPR AGTRTFLEAM QAGKVHLARF VLDALDRSII DCRAEQGRTP LMVAVGLPDP
     ALRARFVRLL LEQGAAVNLR DERGRTALSL ACERGHLDAV QLLVQFSGDP EAADSAGNSP
     VMWAAACGHG AVLEFLVRSF RRLGLRLDRT NRAGLTALQL AAARGHGTCV QALTGPWGRA
     AAAAAARGSN SDSPPGRPAP AASPEHRRPS PRRLPRPLLA RFARAAGGHG GEAGSAGKNS
     GRHRAQGSER PELGRSMSLA LGAVTEEEAA RLRAGALMAL PNSPQSSGTG RWRSQEVLEG
     APPTLAQAPI GLSPHPEGGP GSGRLGLRRR STAPDIPSLV GEAPGPESGP ELEANALSVS
     VPGPNPWQAG TEAVVLRAQR