ANR63_MOUSE
ID ANR63_MOUSE Reviewed; 390 AA.
AC A2ARS0;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Ankyrin repeat domain-containing protein 63 {ECO:0000250|UniProtKB:C9JTQ0};
GN Name=Ankrd63 {ECO:0000250|UniProtKB:C9JTQ0};
GN Synonyms=Gm1337 {ECO:0000312|MGI:MGI:2686183};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:CAM17417.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193 AND SER-304, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AL845470; CAM17417.1; -; Genomic_DNA.
DR CCDS; CCDS38201.1; -.
DR RefSeq; NP_001075440.1; NM_001081971.1.
DR AlphaFoldDB; A2ARS0; -.
DR SMR; A2ARS0; -.
DR STRING; 10090.ENSMUSP00000100542; -.
DR iPTMnet; A2ARS0; -.
DR PhosphoSitePlus; A2ARS0; -.
DR PaxDb; A2ARS0; -.
DR PRIDE; A2ARS0; -.
DR ProteomicsDB; 282123; -.
DR Antibodypedia; 70339; 51 antibodies from 9 providers.
DR DNASU; 383787; -.
DR Ensembl; ENSMUST00000104937; ENSMUSP00000100542; ENSMUSG00000078137.
DR GeneID; 383787; -.
DR KEGG; mmu:383787; -.
DR UCSC; uc008lsh.1; mouse.
DR CTD; 100131244; -.
DR MGI; MGI:2686183; Ankrd63.
DR VEuPathDB; HostDB:ENSMUSG00000078137; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163025; -.
DR HOGENOM; CLU_042924_0_0_1; -.
DR InParanoid; A2ARS0; -.
DR OMA; PNPWQAG; -.
DR OrthoDB; 1073736at2759; -.
DR PhylomeDB; A2ARS0; -.
DR TreeFam; TF333311; -.
DR BioGRID-ORCS; 383787; 1 hit in 71 CRISPR screens.
DR PRO; PR:A2ARS0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2ARS0; protein.
DR Bgee; ENSMUSG00000078137; Expressed in olfactory tubercle and 47 other tissues.
DR Genevisible; A2ARS0; MM.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..390
FT /note="Ankyrin repeat domain-containing protein 63"
FT /id="PRO_0000411003"
FT REPEAT 11..40
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 46..79
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 83..112
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 116..145
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT REPEAT 153..182
FT /note="ANK 5"
FT /evidence="ECO:0000255"
FT REGION 181..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 193
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 390 AA; 41068 MW; 8577D68BDFAE633B CRC64;
MLKPKDLCPR AGTRTFLEAM QAGKVHLARF VLDALDRSII DCRAEQGRTP LMVAVGLPDP
AMRSRFVRLL LEQGAAVNLR DERGRTALSL ACERGHLDAV QLLVQFSGDP EATDSAGNSP
VMWAAACGHG AVLEFLVRSF RRLGLRLDRT NRAGLTALQL AASRGHGTCV QALTGPWGRA
AAAAAARGSN SDSPPGHPAP APSPERRRPS PRRLPRPLLA RFARAAGGHG HGHGHGHGHG
GELASAGKGS VRYRAQGNER PELGRSMSLA LGTMTEEETA RLRAGALMAR PNSPQSSGSG
RWRSQEVLEG APLALMQAPV GLSPHPEGCP GSGRLGLRRR STAPDIPSLV GEASGPESGP
ELENNALPFS VPGPKPWQAG TEAVVLQAQR