ANR65_HUMAN
ID ANR65_HUMAN Reviewed; 399 AA.
AC E5RJM6; J3KR93;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Ankyrin repeat domain-containing protein 65;
GN Name=ANKRD65;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 39-186 (ISOFORM 1).
RC TISSUE=Astrocytoma, Kidney, and Retinoblastoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=E5RJM6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E5RJM6-2; Sequence=VSP_042085, VSP_042086;
CC Name=3;
CC IsoId=E5RJM6-3; Sequence=VSP_045962, VSP_045963;
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DR EMBL; AL391244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063445; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC094869; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AI522076; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS55558.1; -. [E5RJM6-1]
DR CCDS; CCDS57962.1; -. [E5RJM6-2]
DR CCDS; CCDS57963.1; -. [E5RJM6-3]
DR RefSeq; NP_001138682.1; NM_001145210.2. [E5RJM6-1]
DR RefSeq; NP_001230464.1; NM_001243535.1. [E5RJM6-2]
DR RefSeq; NP_001230465.1; NM_001243536.1. [E5RJM6-3]
DR RefSeq; XP_005244809.1; XM_005244752.4. [E5RJM6-1]
DR RefSeq; XP_006710710.1; XM_006710647.3. [E5RJM6-1]
DR RefSeq; XP_011539791.1; XM_011541489.2. [E5RJM6-1]
DR RefSeq; XP_016856813.1; XM_017001324.1. [E5RJM6-1]
DR RefSeq; XP_016856814.1; XM_017001325.1.
DR RefSeq; XP_016856815.1; XM_017001326.1.
DR AlphaFoldDB; E5RJM6; -.
DR SMR; E5RJM6; -.
DR BioGRID; 137829; 10.
DR STRING; 9606.ENSP00000445688; -.
DR PhosphoSitePlus; E5RJM6; -.
DR BioMuta; ANKRD65; -.
DR jPOST; E5RJM6; -.
DR MassIVE; E5RJM6; -.
DR PaxDb; E5RJM6; -.
DR PeptideAtlas; E5RJM6; -.
DR PRIDE; E5RJM6; -.
DR ProteomicsDB; 16650; -. [E5RJM6-1]
DR ProteomicsDB; 16651; -. [E5RJM6-2]
DR Antibodypedia; 58071; 33 antibodies from 10 providers.
DR DNASU; 441869; -.
DR Ensembl; ENST00000427211.3; ENSP00000428419.1; ENSG00000235098.9. [E5RJM6-2]
DR Ensembl; ENST00000442470.1; ENSP00000428201.1; ENSG00000235098.9. [E5RJM6-2]
DR Ensembl; ENST00000454272.2; ENSP00000482314.1; ENSG00000235098.9. [E5RJM6-1]
DR Ensembl; ENST00000520296.5; ENSP00000429035.1; ENSG00000235098.9. [E5RJM6-3]
DR Ensembl; ENST00000537107.6; ENSP00000445688.1; ENSG00000235098.9. [E5RJM6-1]
DR GeneID; 441869; -.
DR KEGG; hsa:441869; -.
DR MANE-Select; ENST00000537107.6; ENSP00000445688.1; NM_001145210.3; NP_001138682.1.
DR UCSC; uc001afp.3; human. [E5RJM6-1]
DR CTD; 441869; -.
DR GeneCards; ANKRD65; -.
DR HGNC; HGNC:42950; ANKRD65.
DR HPA; ENSG00000235098; Low tissue specificity.
DR neXtProt; NX_E5RJM6; -.
DR OpenTargets; ENSG00000235098; -.
DR VEuPathDB; HostDB:ENSG00000235098; -.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000163707; -.
DR HOGENOM; CLU_2849024_0_0_1; -.
DR InParanoid; E5RJM6; -.
DR OMA; LAMEHGH; -.
DR OrthoDB; 812341at2759; -.
DR PhylomeDB; E5RJM6; -.
DR TreeFam; TF329520; -.
DR PathwayCommons; E5RJM6; -.
DR BioGRID-ORCS; 441869; 31 hits in 1058 CRISPR screens.
DR GenomeRNAi; 441869; -.
DR Pharos; E5RJM6; Tdark.
DR PRO; PR:E5RJM6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; E5RJM6; protein.
DR Bgee; ENSG00000235098; Expressed in right uterine tube and 107 other tissues.
DR Genevisible; E5RJM6; HS.
DR Gene3D; 1.25.40.20; -; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..399
FT /note="Ankyrin repeat domain-containing protein 65"
FT /id="PRO_0000414484"
FT REPEAT 40..69
FT /note="ANK 1"
FT REPEAT 73..102
FT /note="ANK 2"
FT REPEAT 106..135
FT /note="ANK 3"
FT REPEAT 139..168
FT /note="ANK 4"
FT REPEAT 176..205
FT /note="ANK 5"
FT REPEAT 207..231
FT /note="ANK 6"
FT REPEAT 235..264
FT /note="ANK 7"
FT REPEAT 268..297
FT /note="ANK 8"
FT REPEAT 301..330
FT /note="ANK 9"
FT REPEAT 334..363
FT /note="ANK 10"
FT REGION 377..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 65
FT /note="A -> H (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045962"
FT VAR_SEQ 66..399
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045963"
FT VAR_SEQ 71..173
FT /note="DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRV
FT AELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAE -> TLRC
FT CWATGQTQASGTGMAALRCTGLPPEDTCLPSSCWSPRGPRWMRGTPWASHPCITPLGKA
FT TWRLPAACWTGVPRWMLPAGSERPPYTWLQSEGMGLPWGFC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042085"
FT VAR_SEQ 174..399
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042086"
SQ SEQUENCE 399 AA; 41497 MW; 13AE59F52E54CF4A CRC64;
MDSQRPEPRE EEEEEQELRW MELDSEEALG TRTEGPSVVQ GWGHLLQAVW RGPAGLVTQL
LRQGASVEER DHAGRTPLHL AVLRGHAPLV RLLLQRGAPV GAVDRAGRTA LHEAAWHGHS
RVAELLLQRG ASAAARSGTG LTPLHWAAAL GHTLLAARLL EAPGPGPAAA EAEDARGWTA
AHWAAAGGRL AVLELLAAGG AGLDGALLVA AAAGRGAALR FLLARGARVD ARDGAGATAL
GLAAALGRSQ DIEVLLGHGA DPGIRDRHGR SALHRAAARG HLLAVQLLVT QGAEVDARDT
LGLTPLHHAS REGHVEVAGC LLDRGAQVDA TGWLRKTPLH LAAERGHGPT VGLLLSRGAS
PTLRTQWAEV AQMPEGDLPQ ALPELGGGEK ECEGIESTG
