ID   ANR66_HUMAN             Reviewed;         196 AA.
AC   B4E2M5;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 3.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Ankyrin repeat domain-containing protein 66;
GN   Name=ANKRD66;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG65187.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL161618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL451143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK304342; BAG65187.1; ALT_INIT; mRNA.
DR   CCDS; CCDS59024.1; -.
DR   RefSeq; NP_001155907.2; NM_001162435.2.
DR   AlphaFoldDB; B4E2M5; -.
DR   IntAct; B4E2M5; 1.
DR   MINT; B4E2M5; -.
DR   STRING; 9606.ENSP00000454770; -.
DR   iPTMnet; B4E2M5; -.
DR   PhosphoSitePlus; B4E2M5; -.
DR   BioMuta; ANKRD66; -.
DR   MassIVE; B4E2M5; -.
DR   PaxDb; B4E2M5; -.
DR   PeptideAtlas; B4E2M5; -.
DR   PRIDE; B4E2M5; -.
DR   Antibodypedia; 76898; 1 antibodies from 1 providers.
DR   DNASU; 100287718; -.
DR   Ensembl; ENST00000565422.3; ENSP00000454770.2; ENSG00000230062.7.
DR   GeneID; 100287718; -.
DR   KEGG; hsa:100287718; -.
DR   MANE-Select; ENST00000565422.3; ENSP00000454770.2; NM_001162435.3; NP_001155907.3.
DR   UCSC; uc011dwf.3; human.
DR   CTD; 100287718; -.
DR   GeneCards; ANKRD66; -.
DR   HGNC; HGNC:44669; ANKRD66.
DR   HPA; ENSG00000230062; Tissue enriched (fallopian).
DR   neXtProt; NX_B4E2M5; -.
DR   OpenTargets; ENSG00000230062; -.
DR   VEuPathDB; HostDB:ENSG00000230062; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00610000086772; -.
DR   HOGENOM; CLU_000134_22_0_1; -.
DR   InParanoid; B4E2M5; -.
DR   OMA; SLNQNMN; -.
DR   OrthoDB; 1454074at2759; -.
DR   PhylomeDB; B4E2M5; -.
DR   PathwayCommons; B4E2M5; -.
DR   BioGRID-ORCS; 100287718; 8 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 100287718; -.
DR   Pharos; B4E2M5; Tdark.
DR   PRO; PR:B4E2M5; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; B4E2M5; protein.
DR   Bgee; ENSG00000230062; Expressed in right uterine tube and 28 other tissues.
DR   ExpressionAtlas; B4E2M5; baseline and differential.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..196
FT                   /note="Ankyrin repeat domain-containing protein 66"
FT                   /id="PRO_0000421258"
FT   REPEAT          7..37
FT                   /note="ANK 1"
FT   REPEAT          43..72
FT                   /note="ANK 2"
FT   REPEAT          76..105
FT                   /note="ANK 3"
FT   REGION          152..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..196
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   196 AA;  22026 MW;  62B72DFA47E5A1B1 CRC64;
     MELAKMSDMT KLHQAVAAGD YSLVKKILKK GLCDPNYKDV DWNDRTPLHW AAIKGQMEVI
     RLLIEYGARP CLVTSVGWTP AHFAAEAGHL NILKTLHALH AAIDAPDFFG DTPKRIAQIY
     GQKACVAFLE KAEPECQDHR CAAQQKGLPL DERDEDWDAK KRELELSLPS LNQNMNKKNK
     KSRGPTRPSN TKGRRV