ID   ANRA2_BOVIN             Reviewed;         313 AA.
AC   Q2KI79;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Ankyrin repeat family A protein 2;
GN   Name=ANKRA2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate the interaction between the 3M complex and the
CC       histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate
CC       LRP2/megalin (By similarity). {ECO:0000250|UniProtKB:A2ARV4,
CC       ECO:0000250|UniProtKB:Q9H9E1}.
CC   -!- SUBUNIT: Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif);
CC       mediates the interaction with the 3M complex which is composed of
CC       CCDC8, CUL7 and OBSL1. Interacts (via ANK repeats) with HDAC4 (via
CC       PxLPxI/L motif). Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L
CC       motif). Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L
CC       motif). Interacts (via ANK repeats) with RFX7 (via PxLPxI/L motif) (By
CC       similarity). Interacts with AHRR (By similarity). Interacts with NEK6
CC       (By similarity). {ECO:0000250|UniProtKB:Q99PE2,
CC       ECO:0000250|UniProtKB:Q9H9E1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q99PE2}. Membrane
CC       {ECO:0000250|UniProtKB:Q99PE2}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q99PE2}.
CC   -!- DOMAIN: The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate
CC       interaction with a wide array of PxLPxI/L motif-containing proteins
CC       including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain
CC       a Ser or a Thr residue in position 2, which phosphorylation prevents
CC       the interaction with ANKRA2. {ECO:0000250|UniProtKB:Q9H9E1}.
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DR   EMBL; BC112737; AAI12738.1; -; mRNA.
DR   RefSeq; NP_001039754.1; NM_001046289.2.
DR   AlphaFoldDB; Q2KI79; -.
DR   SMR; Q2KI79; -.
DR   STRING; 9913.ENSBTAP00000024557; -.
DR   PaxDb; Q2KI79; -.
DR   Ensembl; ENSBTAT00000024557; ENSBTAP00000024557; ENSBTAG00000018452.
DR   GeneID; 528003; -.
DR   KEGG; bta:528003; -.
DR   CTD; 57763; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018452; -.
DR   VGNC; VGNC:25907; ANKRA2.
DR   eggNOG; KOG0502; Eukaryota.
DR   GeneTree; ENSGT00940000157156; -.
DR   HOGENOM; CLU_078123_0_0_1; -.
DR   InParanoid; Q2KI79; -.
DR   OMA; LMWACAH; -.
DR   OrthoDB; 1348558at2759; -.
DR   TreeFam; TF333112; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000018452; Expressed in oocyte and 102 other tissues.
DR   GO; GO:1990393; C:3M complex; IEA:Ensembl.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0043254; P:regulation of protein-containing complex assembly; ISS:UniProtKB.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat.
FT   CHAIN           1..313
FT                   /note="Ankyrin repeat family A protein 2"
FT                   /id="PRO_0000247543"
FT   REPEAT          148..180
FT                   /note="ANK 1"
FT   REPEAT          181..213
FT                   /note="ANK 2"
FT   REPEAT          214..246
FT                   /note="ANK 3"
FT   REPEAT          247..279
FT                   /note="ANK 4"
FT   REPEAT          280..313
FT                   /note="ANK 5"
SQ   SEQUENCE   313 AA;  34159 MW;  9EFA0BB35BAB7B06 CRC64;
     MATSANLDIG AQLIVEECPS SYSLSGMPDI KIEHQPDSSA EEGSAQGVAM GMKFILPNRF
     DMNVCSRFVK SLNEEDSKNI QDQVNSDLEV ASVLFKAECN IHTSPSPGIQ VRHVYTPSTT
     KHFSPIKQST TLTNKHRGNE VSTTPLLANS LSVHQLAAQG EMLYLATRIE QENVINHTDE
     EGFTPLMWAA AHGQIAVVEF LLQNGADPQL LGKGRESALS LACSKGYTDI VKMLLDCGVD
     VNEYDWNGGT PLLYAVHGNH VKCVKMLLEN GADPTIETDS GYNSMDLAVA LGYRSVQQVI
     ESHLLKLLQN IKE