ID   HIS7_TRIHA              Reviewed;         208 AA.
AC   P34041;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=his3; Synonyms=igh;
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=5544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1406594; DOI=10.1007/bf00538709;
RA   Goldman G.H., Demolder J., Dewaele S., Herrera-Estrella A., Geremia R.A.,
RA   van Montagu M., Contreras R.;
RT   "Molecular cloning of the imidazoleglycerolphosphate dehydratase gene of
RT   Trichoderma harzianum by genetic complementation in Saccharomyces
RT   cerevisiae using a direct expression vector.";
RL   Mol. Gen. Genet. 234:481-488(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; Z11528; CAA77617.1; -; mRNA.
DR   PIR; S26196; S26196.
DR   AlphaFoldDB; P34041; -.
DR   SMR; P34041; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase.
FT   CHAIN           1..208
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158249"
SQ   SEQUENCE   208 AA;  22356 MW;  252A039D2149238D CRC64;
     MASPLPVRAA ALSRDTNETS IQIALSIDGG ELPQDADPRL LEASSAHASQ TSKSQVISIN
     TGIGFLDHML HALAKHAGWS MALNCKGDLH IDDHHTAEDC CIAVGTTFAK ALGALTGVAR
     FGYAYAPLDE ALSRAVVDLS NRPYTVVDLG LKREKLGELS CEMIPHCLQS FAQAARITLH
     VDCLRGDNDH HRAESAFKAL AVAVRWYD