ID   HIS7_ZYGBA              Reviewed;         223 AA.
AC   Q96UK2;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=HIS3;
OS   Zygosaccharomyces bailii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=4954;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 36947;
RA   Branduardi P., Sauer M., Porro D.;
RT   "Molecular cloning of the Zygosaccharomyces bailii imidazoleglycerol-
RT   phosphate dehydratase gene.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; AY050224; AAL02423.1; -; mRNA.
DR   AlphaFoldDB; Q96UK2; -.
DR   SMR; Q96UK2; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Histidine biosynthesis; Lyase.
FT   CHAIN           1..223
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158251"
SQ   SEQUENCE   223 AA;  24284 MW;  957DE11DF7662204 CRC64;
     MIGEHKALVQ RITNETKIQI AISLNGGHIE LPESILDKNP TQENNIATQA TTSQVIDIHT
     GVGFLDHMIH ALAKHSGWSL IVECIGDLHI DDHHTTEDCG IALGEAFKQA LGQVRGVKRF
     GCGFAPLDEA LSRAVVDLSN RPYAVIDLGL KREKIGDLSC EMIPHFLESF IEAARLTVHI
     DCLRGFNDHH RSESAFKALA VAIREATAPN GTNDVPSTKG VLM